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Homocysteine in Alzheimer disease and vascular dementia.

Abstract

Hyperhomocysteinemia is an important risk factor for atherosclerosis and it has recently been suggested as a diagnostic marker for Alzheimer disease (AD). The present studies compared homocysteinemia in patients with AD and with vascular dementia (VD),as well as in controls. Homocysteinemia was measured in 137 probable AD patients,diagnosed by the NINCDS-ADRDA criteria, in 40 probably VD patients diagnosed by the NINDS-AIREN criteria, and in 42 control subjects. Homocysteine levels were significantly higher in AD and VD groups, than in controls, however, VD patients were significantly older than the controls. The proportion of females was higher in the AD group, while serum folate and B12 vitamin levels tended to be lower in both the AD and VD groups, compared to the controls. In order to adjust the results for these potentially interfering factors, a multivariate ANCOVA calculation was performed, where homocysteine levels were analyzed considering 2 grouping factors (gender and neurological type) and 4 covariates (age, albumin,serum folate and vitamin B12). This analysis confirmed that even after adjusting for the covariates, the difference between AD and VD groups and controls remain highly significant,while neither the gender itself, nor the interaction of gender and the neurological type had any significant influence on the homocysteine levels. The main finding, therefore, is a significant increase of homocysteine levels in the 2 disease groups, compared to controls.

Authors+Show Affiliations

Medicine Department, Ca' Foncello Hospital, I -31 100 Treviso, Italy. m.gallucci@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15207414

Citation

Gallucci, M, et al. "Homocysteine in Alzheimer Disease and Vascular Dementia." Archives of Gerontology and Geriatrics. Supplement, 2004, pp. 195-200.
Gallucci M, Zanardo A, De Valentin L, et al. Homocysteine in Alzheimer disease and vascular dementia. Arch Gerontol Geriatr Suppl. 2004.
Gallucci, M., Zanardo, A., De Valentin, L., & Vianello, A. (2004). Homocysteine in Alzheimer disease and vascular dementia. Archives of Gerontology and Geriatrics. Supplement, (9), 195-200.
Gallucci M, et al. Homocysteine in Alzheimer Disease and Vascular Dementia. Arch Gerontol Geriatr Suppl. 2004;(9)195-200. PubMed PMID: 15207414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine in Alzheimer disease and vascular dementia. AU - Gallucci,M, AU - Zanardo,A, AU - De Valentin,L, AU - Vianello,A, PY - 2004/6/23/pubmed PY - 2004/10/22/medline PY - 2004/6/23/entrez SP - 195 EP - 200 JF - Archives of gerontology and geriatrics. Supplement JO - Arch Gerontol Geriatr Suppl IS - 9 N2 - Hyperhomocysteinemia is an important risk factor for atherosclerosis and it has recently been suggested as a diagnostic marker for Alzheimer disease (AD). The present studies compared homocysteinemia in patients with AD and with vascular dementia (VD),as well as in controls. Homocysteinemia was measured in 137 probable AD patients,diagnosed by the NINCDS-ADRDA criteria, in 40 probably VD patients diagnosed by the NINDS-AIREN criteria, and in 42 control subjects. Homocysteine levels were significantly higher in AD and VD groups, than in controls, however, VD patients were significantly older than the controls. The proportion of females was higher in the AD group, while serum folate and B12 vitamin levels tended to be lower in both the AD and VD groups, compared to the controls. In order to adjust the results for these potentially interfering factors, a multivariate ANCOVA calculation was performed, where homocysteine levels were analyzed considering 2 grouping factors (gender and neurological type) and 4 covariates (age, albumin,serum folate and vitamin B12). This analysis confirmed that even after adjusting for the covariates, the difference between AD and VD groups and controls remain highly significant,while neither the gender itself, nor the interaction of gender and the neurological type had any significant influence on the homocysteine levels. The main finding, therefore, is a significant increase of homocysteine levels in the 2 disease groups, compared to controls. SN - 0924-7947 UR - https://www.unboundmedicine.com/medline/citation/15207414/Homocysteine_in_Alzheimer_disease_and_vascular_dementia_ L2 - http://www.diseaseinfosearch.org/result/349 DB - PRIME DP - Unbound Medicine ER -