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A qualitative analysis of the mini mental state examination on Alzheimer's disease patients treated with cholinesterase inhibitors.

Abstract

The improvement in cognitive performances due to cholinesterase inhibitors (ChEls) is not homogeneous among Alzheimer's disease (AD) subjects. Aim of this study is to evaluate whether a specific pattern of change in mini mental state examination (MMSE) could be observed in AD subjects after 9-month treatment with ChEls. From September 2000 to September 2002, 99 subjects enrolled in the CRONOS project. They have never been previously treated with ChEls. All of them completed both the 3- and the 9-month follow-up. The multidimensional assessment included MMSE, activity of daily living (ADL), instrumental activity of daily living (IADL), somatic health status, according to design of the CRONOSproject. The MMSE was analyzed both as a total score and disaggregated in 11 items. All subjects were divided in 2 groups according to the degree of change in MMSE total score from baseline to the 9th month. Subjects with a change </= -1 were defined as non-responders(NR), whereas those with a change >0 as responders (R). At start, no statistically significant differences were found between the 2 groups. MMSE score was significantly higher in the R group both at 3 (p < 0.0001) and 9 months (p < 0.0001), while functional status (ADL and IADL) was significantly lower in NR group at 9 months (p = 0.025; p =0.018, respectively). In MMSE qualitative analysis of 3-month, NR significantly worsened in temporal (p </= 0.05) and spatial orientation (p </= 0.001), and in delayed recall items (p </= 0.0005) in comparison to their counterpart. At 9-month the differences between the 2 groups were observed also for registration (p < 0.001), attention (p </= 0.0005), obeying oral commands (p < 0.0005), reading and obeying commands (p </= 0.0005), writing a sentence (p </= 0.0005) and copying a design (p </= 0.05). In a multivariate regression model, after adjustment for demographic (age, education, gender) and clinical factors (duration of disease), only the change at 3 months in 5 MMSE items (temporal and spatial orientation,delayed recall, obeying an oral command and reading and obeying command) is associated with global cognitive change observed at 9 months. Data suggest that the change in cognitive performances of AD subjects treated with ChEls involves few and specific MMSE items at 3-month, while it tend to generalize to almost all the others at 9-month treatment.

Authors+Show Affiliations

Alzheimer's Evaluation Unit, Ancelle della Caritá Hospital, I-26100 Cremona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

15207422

Citation

Lucchi, E, et al. "A Qualitative Analysis of the Mini Mental State Examination On Alzheimer's Disease Patients Treated With Cholinesterase Inhibitors." Archives of Gerontology and Geriatrics. Supplement, 2004, pp. 253-63.
Lucchi E, Minicuci N, Magnifico F, et al. A qualitative analysis of the mini mental state examination on Alzheimer's disease patients treated with cholinesterase inhibitors. Arch Gerontol Geriatr Suppl. 2004.
Lucchi, E., Minicuci, N., Magnifico, F., Mondini, S., Calza, A., Avanzi, S., Villani, D., Bellelli, G., & Trabucchi, M. (2004). A qualitative analysis of the mini mental state examination on Alzheimer's disease patients treated with cholinesterase inhibitors. Archives of Gerontology and Geriatrics. Supplement, (9), 253-63.
Lucchi E, et al. A Qualitative Analysis of the Mini Mental State Examination On Alzheimer's Disease Patients Treated With Cholinesterase Inhibitors. Arch Gerontol Geriatr Suppl. 2004;(9)253-63. PubMed PMID: 15207422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A qualitative analysis of the mini mental state examination on Alzheimer's disease patients treated with cholinesterase inhibitors. AU - Lucchi,E, AU - Minicuci,N, AU - Magnifico,F, AU - Mondini,S, AU - Calza,A, AU - Avanzi,S, AU - Villani,D, AU - Bellelli,G, AU - Trabucchi,M, PY - 2004/6/23/pubmed PY - 2004/10/22/medline PY - 2004/6/23/entrez SP - 253 EP - 63 JF - Archives of gerontology and geriatrics. Supplement JO - Arch Gerontol Geriatr Suppl IS - 9 N2 - The improvement in cognitive performances due to cholinesterase inhibitors (ChEls) is not homogeneous among Alzheimer's disease (AD) subjects. Aim of this study is to evaluate whether a specific pattern of change in mini mental state examination (MMSE) could be observed in AD subjects after 9-month treatment with ChEls. From September 2000 to September 2002, 99 subjects enrolled in the CRONOS project. They have never been previously treated with ChEls. All of them completed both the 3- and the 9-month follow-up. The multidimensional assessment included MMSE, activity of daily living (ADL), instrumental activity of daily living (IADL), somatic health status, according to design of the CRONOSproject. The MMSE was analyzed both as a total score and disaggregated in 11 items. All subjects were divided in 2 groups according to the degree of change in MMSE total score from baseline to the 9th month. Subjects with a change </= -1 were defined as non-responders(NR), whereas those with a change >0 as responders (R). At start, no statistically significant differences were found between the 2 groups. MMSE score was significantly higher in the R group both at 3 (p < 0.0001) and 9 months (p < 0.0001), while functional status (ADL and IADL) was significantly lower in NR group at 9 months (p = 0.025; p =0.018, respectively). In MMSE qualitative analysis of 3-month, NR significantly worsened in temporal (p </= 0.05) and spatial orientation (p </= 0.001), and in delayed recall items (p </= 0.0005) in comparison to their counterpart. At 9-month the differences between the 2 groups were observed also for registration (p < 0.001), attention (p </= 0.0005), obeying oral commands (p < 0.0005), reading and obeying commands (p </= 0.0005), writing a sentence (p </= 0.0005) and copying a design (p </= 0.05). In a multivariate regression model, after adjustment for demographic (age, education, gender) and clinical factors (duration of disease), only the change at 3 months in 5 MMSE items (temporal and spatial orientation,delayed recall, obeying an oral command and reading and obeying command) is associated with global cognitive change observed at 9 months. Data suggest that the change in cognitive performances of AD subjects treated with ChEls involves few and specific MMSE items at 3-month, while it tend to generalize to almost all the others at 9-month treatment. SN - 0924-7947 UR - https://www.unboundmedicine.com/medline/citation/15207422/A_qualitative_analysis_of_the_mini_mental_state_examination_on_Alzheimer's_disease_patients_treated_with_cholinesterase_inhibitors_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -