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Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations.
Eur J Pharm Biopharm 2004; 58(1):83-90EJ

Abstract

Aqueous dispersions of lipid nanoparticles are being investigated as drug delivery systems for different therapeutic purposes. One of their interesting features is the possibility of topical use, for which these systems have to be incorporated into commonly used dermal carriers, such as creams or hydrogels, in order to have a proper semisolid consistency. For the present investigation four different gel-forming agents (xanthan gum, hydroxyethylcellulose 4000, Carbopol943 and chitosan) were selected for hydrogel preparation. Aqueous dispersions of lipid nanoparticles--solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)--made from tripalmitin were prepared by hot high pressure homogenization and then incorporated into the freshly prepared hydrogels. NLC differ from SLN due to the presence of a liquid lipid (Miglyol812) in the lipid matrix. Lipid nanoparticles were physically characterized before and after their incorporation into hydrogels. By means of rheological investigations it could be demonstrated that physical properties of the dispersed lipid phase have a great impact on the rheological properties of the prepared semisolid formulations. By employing an oscillation frequency sweep test, significant differences in elastic response of SLN and NLC aqueous dispersions could be observed.

Authors+Show Affiliations

Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15207541

Citation

Souto, E B., et al. "Evaluation of the Physical Stability of SLN and NLC Before and After Incorporation Into Hydrogel Formulations." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 58, no. 1, 2004, pp. 83-90.
Souto EB, Wissing SA, Barbosa CM, et al. Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. Eur J Pharm Biopharm. 2004;58(1):83-90.
Souto, E. B., Wissing, S. A., Barbosa, C. M., & Müller, R. H. (2004). Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 58(1), pp. 83-90.
Souto EB, et al. Evaluation of the Physical Stability of SLN and NLC Before and After Incorporation Into Hydrogel Formulations. Eur J Pharm Biopharm. 2004;58(1):83-90. PubMed PMID: 15207541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations. AU - Souto,E B, AU - Wissing,S A, AU - Barbosa,C M, AU - Müller,R H, PY - 2003/10/04/received PY - 2003/10/07/revised PY - 2004/02/24/accepted PY - 2004/6/23/pubmed PY - 2005/1/19/medline PY - 2004/6/23/entrez SP - 83 EP - 90 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 58 IS - 1 N2 - Aqueous dispersions of lipid nanoparticles are being investigated as drug delivery systems for different therapeutic purposes. One of their interesting features is the possibility of topical use, for which these systems have to be incorporated into commonly used dermal carriers, such as creams or hydrogels, in order to have a proper semisolid consistency. For the present investigation four different gel-forming agents (xanthan gum, hydroxyethylcellulose 4000, Carbopol943 and chitosan) were selected for hydrogel preparation. Aqueous dispersions of lipid nanoparticles--solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)--made from tripalmitin were prepared by hot high pressure homogenization and then incorporated into the freshly prepared hydrogels. NLC differ from SLN due to the presence of a liquid lipid (Miglyol812) in the lipid matrix. Lipid nanoparticles were physically characterized before and after their incorporation into hydrogels. By means of rheological investigations it could be demonstrated that physical properties of the dispersed lipid phase have a great impact on the rheological properties of the prepared semisolid formulations. By employing an oscillation frequency sweep test, significant differences in elastic response of SLN and NLC aqueous dispersions could be observed. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/15207541/Evaluation_of_the_physical_stability_of_SLN_and_NLC_before_and_after_incorporation_into_hydrogel_formulations_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S093964110400061X DB - PRIME DP - Unbound Medicine ER -