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Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency.
Clin Immunol 2004; 112(1):24-9CI

Abstract

Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae.

Authors+Show Affiliations

Department of Immunology, Oxford Radcliffe Hospitals, John Radcliffe Campus, Headington, Oxford OX3 9DU, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15207778

Citation

Aslam, A, et al. "Vitamin E Deficiency Induced Neurological Disease in Common Variable Immunodeficiency: Two Cases and a Review of the Literature of Vitamin E Deficiency." Clinical Immunology (Orlando, Fla.), vol. 112, no. 1, 2004, pp. 24-9.
Aslam A, Misbah SA, Talbot K, et al. Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. Clin Immunol. 2004;112(1):24-9.
Aslam, A., Misbah, S. A., Talbot, K., & Chapel, H. (2004). Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. Clinical Immunology (Orlando, Fla.), 112(1), pp. 24-9.
Aslam A, et al. Vitamin E Deficiency Induced Neurological Disease in Common Variable Immunodeficiency: Two Cases and a Review of the Literature of Vitamin E Deficiency. Clin Immunol. 2004;112(1):24-9. PubMed PMID: 15207778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. AU - Aslam,A, AU - Misbah,S A, AU - Talbot,K, AU - Chapel,H, PY - 2003/10/01/received PY - 2004/01/22/revised PY - 2004/02/03/accepted PY - 2004/6/23/pubmed PY - 2004/8/20/medline PY - 2004/6/23/entrez SP - 24 EP - 9 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 112 IS - 1 N2 - Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/15207778/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521661604000348 DB - PRIME DP - Unbound Medicine ER -