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Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency.

Abstract

Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae.

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  • Authors+Show Affiliations

    ,

    Department of Immunology, Oxford Radcliffe Hospitals, John Radcliffe Campus, Headington, Oxford OX3 9DU, UK.

    , ,

    Source

    MeSH

    Adult
    Common Variable Immunodeficiency
    Female
    Humans
    Male
    Middle Aged
    Nervous System Diseases
    Vitamin E Deficiency

    Pub Type(s)

    Case Reports
    Journal Article
    Review

    Language

    eng

    PubMed ID

    15207778

    Citation

    Aslam, A, et al. "Vitamin E Deficiency Induced Neurological Disease in Common Variable Immunodeficiency: Two Cases and a Review of the Literature of Vitamin E Deficiency." Clinical Immunology (Orlando, Fla.), vol. 112, no. 1, 2004, pp. 24-9.
    Aslam A, Misbah SA, Talbot K, et al. Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. Clin Immunol. 2004;112(1):24-9.
    Aslam, A., Misbah, S. A., Talbot, K., & Chapel, H. (2004). Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. Clinical Immunology (Orlando, Fla.), 112(1), pp. 24-9.
    Aslam A, et al. Vitamin E Deficiency Induced Neurological Disease in Common Variable Immunodeficiency: Two Cases and a Review of the Literature of Vitamin E Deficiency. Clin Immunol. 2004;112(1):24-9. PubMed PMID: 15207778.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. AU - Aslam,A, AU - Misbah,S A, AU - Talbot,K, AU - Chapel,H, PY - 2003/10/01/received PY - 2004/01/22/revised PY - 2004/02/03/accepted PY - 2004/6/23/pubmed PY - 2004/8/20/medline PY - 2004/6/23/entrez SP - 24 EP - 9 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 112 IS - 1 N2 - Vitamin E deficiency causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic vitamin E deficiency has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients with the associated enteropathy who developed neurological disease because of vitamin E deficiency, suggesting a possible predisposition to developing this complication. We recommend that all CVID patients with evidence of an enteropathy be screened for vitamin E deficiency, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/15207778/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521661604000348 DB - PRIME DP - Unbound Medicine ER -