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Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation.
Clin Immunol 2004; 112(1):66-77CI

Abstract

TNF can potentiate IFN-gamma production by activated T cells and other members of the TNF-superfamily play key roles in this effect. A newly discovered TNF-superfamily cytokine (TL1A) could also be involved in initiating or promoting the Th1 response by enhancing IFN-gamma production. The purpose of this study was to assess the role of recombinant TL1A on IFN-gamma production by cultured PBMC and lamina propria LPMC and to determine whether TL1A expression is altered in inflammatory bowel disease. IFN-gamma, but not IL-4 or IL-10 production by PBMC and LPL, was dose-dependently augmented by TL1A (or by activation of its receptor, death domain receptor 3 [DR3], with specific mAb) independently of, but in synergy with, IL-12 and IL-18. T cell activating stimuli induced expression of TL1A on the cell membrane (mb-TL1A) in a fraction of peripheral blood (PB) T cells. In the intestinal mucosa, a fraction of lamina propria (LP) T cells, especially CD4+ cells, constitutively expressed mb-TL1A, and the fraction increased in mucosal inflammation. A higher fraction of cells also express the TL1A receptor DR3 in ulcerative colitis and Crohn's disease. TL1A transcript was several times more abundant in RNA from mucosal biopsies taken from inflamed Crohn's disease lesions than in those taken from uninvolved areas. Expression of TL1A and its receptor DR3 by lamina propria mononuclear cells (LPMC) could have significant influence on the severity of mucosal inflammation.

Authors+Show Affiliations

Cedars-Sinai Inflammatory Bowel Disease Center, Los Angeles, CA 90048, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15207783

Citation

Prehn, John L., et al. "Potential Role for TL1A, the New TNF-family Member and Potent Costimulator of IFN-gamma, in Mucosal Inflammation." Clinical Immunology (Orlando, Fla.), vol. 112, no. 1, 2004, pp. 66-77.
Prehn JL, Mehdizadeh S, Landers CJ, et al. Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin Immunol. 2004;112(1):66-77.
Prehn, J. L., Mehdizadeh, S., Landers, C. J., Luo, X., Cha, S. C., Wei, P., & Targan, S. R. (2004). Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clinical Immunology (Orlando, Fla.), 112(1), pp. 66-77.
Prehn JL, et al. Potential Role for TL1A, the New TNF-family Member and Potent Costimulator of IFN-gamma, in Mucosal Inflammation. Clin Immunol. 2004;112(1):66-77. PubMed PMID: 15207783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. AU - Prehn,John L, AU - Mehdizadeh,Shahab, AU - Landers,Carol J, AU - Luo,Xia, AU - Cha,Stephanie C, AU - Wei,Ping, AU - Targan,Stephan R, PY - 2003/08/11/received PY - 2004/02/20/accepted PY - 2004/6/23/pubmed PY - 2004/8/20/medline PY - 2004/6/23/entrez SP - 66 EP - 77 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 112 IS - 1 N2 - TNF can potentiate IFN-gamma production by activated T cells and other members of the TNF-superfamily play key roles in this effect. A newly discovered TNF-superfamily cytokine (TL1A) could also be involved in initiating or promoting the Th1 response by enhancing IFN-gamma production. The purpose of this study was to assess the role of recombinant TL1A on IFN-gamma production by cultured PBMC and lamina propria LPMC and to determine whether TL1A expression is altered in inflammatory bowel disease. IFN-gamma, but not IL-4 or IL-10 production by PBMC and LPL, was dose-dependently augmented by TL1A (or by activation of its receptor, death domain receptor 3 [DR3], with specific mAb) independently of, but in synergy with, IL-12 and IL-18. T cell activating stimuli induced expression of TL1A on the cell membrane (mb-TL1A) in a fraction of peripheral blood (PB) T cells. In the intestinal mucosa, a fraction of lamina propria (LP) T cells, especially CD4+ cells, constitutively expressed mb-TL1A, and the fraction increased in mucosal inflammation. A higher fraction of cells also express the TL1A receptor DR3 in ulcerative colitis and Crohn's disease. TL1A transcript was several times more abundant in RNA from mucosal biopsies taken from inflamed Crohn's disease lesions than in those taken from uninvolved areas. Expression of TL1A and its receptor DR3 by lamina propria mononuclear cells (LPMC) could have significant influence on the severity of mucosal inflammation. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/15207783/Potential_role_for_TL1A_the_new_TNF_family_member_and_potent_costimulator_of_IFN_gamma_in_mucosal_inflammation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521661604000555 DB - PRIME DP - Unbound Medicine ER -