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Mechanism of action of the suppression of herpes simplex virus type 2 replication by pterocarnin A.
Microbes Infect. 2004 Jul; 6(8):738-44.MI

Abstract

The purpose of this study was to investigate the in vitro antiviral properties of pterocarnin A, extracted from the bark of Pterocarya stenoptera (Juylandaceae). Results showed that pterocarnin A exhibited anti-herpes simplex virus (HSV) activity. It had a low selectivity index (SI) value and only possessed some level of cell cytotoxic effect at high antiviral concentrations. Mechanism studies demonstrated that pterocarnin A inhibited herpes simplex virus type 2 (HSV-2) from attaching and penetrating into cells. It also actively suppressed HSV-2 multiplication in Vero cells even when added 12 h after infection. This observation indicated that pterocarnin A affected the late stage(s) of HSV-2 infection cycle. Pterocarnin A also significantly reduced viral infectivity at high concentrations. From these observations, it was concluded that pterocarnin A suppressed both early and late in the replication cycle of HSV-2. The various modes of action of pterocarnin A in interfering with certain steps of viral infection thus merit further investigation.

Authors+Show Affiliations

Cheng HY
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, No. 100, Shin-Chuan 1st Road, 807 Kaohsiung, Taiwan, ROC.
Lin TC
No affiliation info available
Yang CM
No affiliation info available
Wang KC
No affiliation info available
Lin CC
No affiliation info available

MeSH

AnimalsAntiviral AgentsChlorocebus aethiopsGallic AcidGlycosidesHerpesvirus 2, HumanJuglandaceaePlant BarkPlant ExtractsVero CellsVirus InactivationVirus Replication

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15207820

Citation

Cheng, Hua-Yew, et al. "Mechanism of Action of the Suppression of Herpes Simplex Virus Type 2 Replication By Pterocarnin A." Microbes and Infection, vol. 6, no. 8, 2004, pp. 738-44.
Cheng HY, Lin TC, Yang CM, et al. Mechanism of action of the suppression of herpes simplex virus type 2 replication by pterocarnin A. Microbes Infect. 2004;6(8):738-44.
Cheng, H. Y., Lin, T. C., Yang, C. M., Wang, K. C., & Lin, C. C. (2004). Mechanism of action of the suppression of herpes simplex virus type 2 replication by pterocarnin A. Microbes and Infection, 6(8), 738-44.
Cheng HY, et al. Mechanism of Action of the Suppression of Herpes Simplex Virus Type 2 Replication By Pterocarnin A. Microbes Infect. 2004;6(8):738-44. PubMed PMID: 15207820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism of action of the suppression of herpes simplex virus type 2 replication by pterocarnin A. AU - Cheng,Hua-Yew, AU - Lin,Ta-Chen, AU - Yang,Chien-Min, AU - Wang,Kuo-Chih, AU - Lin,Chun-Ching, PY - 2004/02/17/received PY - 2004/03/29/accepted PY - 2004/6/23/pubmed PY - 2005/2/18/medline PY - 2004/6/23/entrez SP - 738 EP - 44 JF - Microbes and infection JO - Microbes Infect VL - 6 IS - 8 N2 - The purpose of this study was to investigate the in vitro antiviral properties of pterocarnin A, extracted from the bark of Pterocarya stenoptera (Juylandaceae). Results showed that pterocarnin A exhibited anti-herpes simplex virus (HSV) activity. It had a low selectivity index (SI) value and only possessed some level of cell cytotoxic effect at high antiviral concentrations. Mechanism studies demonstrated that pterocarnin A inhibited herpes simplex virus type 2 (HSV-2) from attaching and penetrating into cells. It also actively suppressed HSV-2 multiplication in Vero cells even when added 12 h after infection. This observation indicated that pterocarnin A affected the late stage(s) of HSV-2 infection cycle. Pterocarnin A also significantly reduced viral infectivity at high concentrations. From these observations, it was concluded that pterocarnin A suppressed both early and late in the replication cycle of HSV-2. The various modes of action of pterocarnin A in interfering with certain steps of viral infection thus merit further investigation. SN - 1286-4579 UR - https://www.unboundmedicine.com/medline/citation/15207820/Mechanism_of_action_of_the_suppression_of_herpes_simplex_virus_type_2_replication_by_pterocarnin_A_ DB - PRIME DP - Unbound Medicine ER -