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Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus.
J Diabetes Complications. 2004 Jul-Aug; 18(4):193-7.JD

Abstract

Diabetes mellitus (DM) is a common disease affecting over 124 million individuals worldwide. DM is associated with high risk of atherosclerosis and renal, neural, and ocular damage. Increased oxidant stress has been implicated in the pathogenesis of DM. An increase in serum ceruloplasmin (Cp) levels has also been reported in Type 2 DM. Cp permits the incorporation of iron into transferrin (Trf). Trf inhibits iron ion-dependent OHo formation from H2O2. Patients with diabetes have increased levels of plasma lipid peroxidation products. In this study, we evaluated 50 patients with Type 2 DM and 21 clinically healthy subjects. Patients were divided into two groups. Group I included 29 patients without diabetic complications, Group II 21 with diabetic complications. Serum Cp, Trf, C-reactive protein (CRP), triglyceride (TG), cholesterol (Chol), and malondialdehyde (MDA) levels are studied. Serum Cp, CRP, TG, Chol, and MDA levels in diabetic patients were significantly higher than those of controls. Trf levels were significantly lower in diabetic patients than those of the controls. Cp, CRP, HbA1C, and MDA levels in Group II were significantly higher than those of Group I. Our results indicate that oxygen free radicals are formed in DM and can result in diabetic complications and that a prooxidant/oxidant imbalance is involved in the tissue injury in DM and diabetic complications.

Authors+Show Affiliations

Department of Biochemistry, Medical School, Atatürk University, Erzurum 25240, Turkey. rmemisogullari@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15207835

Citation

Memişoğullari, Ramazan, and Ebubekir Bakan. "Levels of Ceruloplasmin, Transferrin, and Lipid Peroxidation in the Serum of Patients With Type 2 Diabetes Mellitus." Journal of Diabetes and Its Complications, vol. 18, no. 4, 2004, pp. 193-7.
Memişoğullari R, Bakan E. Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus. J Diabetes Complications. 2004;18(4):193-7.
Memişoğullari, R., & Bakan, E. (2004). Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus. Journal of Diabetes and Its Complications, 18(4), 193-7.
Memişoğullari R, Bakan E. Levels of Ceruloplasmin, Transferrin, and Lipid Peroxidation in the Serum of Patients With Type 2 Diabetes Mellitus. J Diabetes Complications. 2004 Jul-Aug;18(4):193-7. PubMed PMID: 15207835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of ceruloplasmin, transferrin, and lipid peroxidation in the serum of patients with Type 2 diabetes mellitus. AU - Memişoğullari,Ramazan, AU - Bakan,Ebubekir, PY - 2002/10/02/received PY - 2003/03/03/revised PY - 2003/03/06/accepted PY - 2004/6/23/pubmed PY - 2004/12/18/medline PY - 2004/6/23/entrez SP - 193 EP - 7 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 18 IS - 4 N2 - Diabetes mellitus (DM) is a common disease affecting over 124 million individuals worldwide. DM is associated with high risk of atherosclerosis and renal, neural, and ocular damage. Increased oxidant stress has been implicated in the pathogenesis of DM. An increase in serum ceruloplasmin (Cp) levels has also been reported in Type 2 DM. Cp permits the incorporation of iron into transferrin (Trf). Trf inhibits iron ion-dependent OHo formation from H2O2. Patients with diabetes have increased levels of plasma lipid peroxidation products. In this study, we evaluated 50 patients with Type 2 DM and 21 clinically healthy subjects. Patients were divided into two groups. Group I included 29 patients without diabetic complications, Group II 21 with diabetic complications. Serum Cp, Trf, C-reactive protein (CRP), triglyceride (TG), cholesterol (Chol), and malondialdehyde (MDA) levels are studied. Serum Cp, CRP, TG, Chol, and MDA levels in diabetic patients were significantly higher than those of controls. Trf levels were significantly lower in diabetic patients than those of the controls. Cp, CRP, HbA1C, and MDA levels in Group II were significantly higher than those of Group I. Our results indicate that oxygen free radicals are formed in DM and can result in diabetic complications and that a prooxidant/oxidant imbalance is involved in the tissue injury in DM and diabetic complications. SN - 1056-8727 UR - https://www.unboundmedicine.com/medline/citation/15207835/Levels_of_ceruloplasmin_transferrin_and_lipid_peroxidation_in_the_serum_of_patients_with_Type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056872703000321 DB - PRIME DP - Unbound Medicine ER -