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Poor glycemic control is associated with increased diastolic blood pressure and heart rate in children with Type 1 diabetes.
J Diabetes Complications. 2004 Jul-Aug; 18(4):220-3.JD

Abstract

Although higher levels of hemoglobin A1c (HbA1c) and blood pressure precede the development of nephropathy in Type 1 diabetes (T1DM), the relationship between glycemic control and cardiovascular factors early in the course of diabetes is not clear. We conducted a retrospective study from clinic data for a 1-year period in 148 children with T1DM aged 12.5+/-4.4 years who had average diabetes duration of 4.5+/-3.3 years. The influence of HbA1c and reported insulin dose on blood pressure and heart rate were analyzed in multivariate linear regression models, statistically adjusted for the effect of race, sex, age, body mass index, and duration of diabetes. There was a significant positive correlation of mean HbA1c with mean diastolic blood pressure (P<.025) and mean heart rate (P<.0004). Higher diastolic blood pressure and heart rate were associated with higher HbA1c. Increased insulin doses were also associated with increased diastolic blood pressure (P<.009) and heart rate (P<.013). Insulin dose and HbA1c were also significantly correlated (P<.001). There was no correlation between mean HbA1c and mean systolic blood pressure. Increased levels of HbA1c and insulin dose are associated with increased diastolic blood pressure and heart rate. Although within the normal range, early increases of diastolic blood pressure and heart may indicate early cardiovascular changes in response to diabetes and potentially contribute to a greater proclivity for later development of nephropathy.

Authors+Show Affiliations

Pediatric Endocrinology/Diabetes, Department of Pediatrics, Louisiana State University Health Sciences Center and Children's Hospital of New Orleans, New Orleans, LA 70118, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15207840

Citation

Torchinsky, Michael Y., et al. "Poor Glycemic Control Is Associated With Increased Diastolic Blood Pressure and Heart Rate in Children With Type 1 Diabetes." Journal of Diabetes and Its Complications, vol. 18, no. 4, 2004, pp. 220-3.
Torchinsky MY, Gomez R, Rao J, et al. Poor glycemic control is associated with increased diastolic blood pressure and heart rate in children with Type 1 diabetes. J Diabetes Complications. 2004;18(4):220-3.
Torchinsky, M. Y., Gomez, R., Rao, J., Vargas, A., Mercante, D. E., & Chalew, S. A. (2004). Poor glycemic control is associated with increased diastolic blood pressure and heart rate in children with Type 1 diabetes. Journal of Diabetes and Its Complications, 18(4), 220-3.
Torchinsky MY, et al. Poor Glycemic Control Is Associated With Increased Diastolic Blood Pressure and Heart Rate in Children With Type 1 Diabetes. J Diabetes Complications. 2004 Jul-Aug;18(4):220-3. PubMed PMID: 15207840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poor glycemic control is associated with increased diastolic blood pressure and heart rate in children with Type 1 diabetes. AU - Torchinsky,Michael Y, AU - Gomez,Ricardo, AU - Rao,Jay, AU - Vargas,Alfonso, AU - Mercante,Donald E, AU - Chalew,Stuart A, PY - 2002/12/30/received PY - 2003/02/20/revised PY - 2003/03/03/accepted PY - 2004/6/23/pubmed PY - 2004/12/18/medline PY - 2004/6/23/entrez SP - 220 EP - 3 JF - Journal of diabetes and its complications JO - J Diabetes Complications VL - 18 IS - 4 N2 - Although higher levels of hemoglobin A1c (HbA1c) and blood pressure precede the development of nephropathy in Type 1 diabetes (T1DM), the relationship between glycemic control and cardiovascular factors early in the course of diabetes is not clear. We conducted a retrospective study from clinic data for a 1-year period in 148 children with T1DM aged 12.5+/-4.4 years who had average diabetes duration of 4.5+/-3.3 years. The influence of HbA1c and reported insulin dose on blood pressure and heart rate were analyzed in multivariate linear regression models, statistically adjusted for the effect of race, sex, age, body mass index, and duration of diabetes. There was a significant positive correlation of mean HbA1c with mean diastolic blood pressure (P<.025) and mean heart rate (P<.0004). Higher diastolic blood pressure and heart rate were associated with higher HbA1c. Increased insulin doses were also associated with increased diastolic blood pressure (P<.009) and heart rate (P<.013). Insulin dose and HbA1c were also significantly correlated (P<.001). There was no correlation between mean HbA1c and mean systolic blood pressure. Increased levels of HbA1c and insulin dose are associated with increased diastolic blood pressure and heart rate. Although within the normal range, early increases of diastolic blood pressure and heart may indicate early cardiovascular changes in response to diabetes and potentially contribute to a greater proclivity for later development of nephropathy. SN - 1056-8727 UR - https://www.unboundmedicine.com/medline/citation/15207840/Poor_glycemic_control_is_associated_with_increased_diastolic_blood_pressure_and_heart_rate_in_children_with_Type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S105687270300031X DB - PRIME DP - Unbound Medicine ER -