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The Omega-3 Index: a new risk factor for death from coronary heart disease?
Prev Med. 2004 Jul; 39(1):212-20.PM

Abstract

BACKGROUND

Low intakes or blood levels of eicosapentaenoic and docosahexaenoic acids (EPA + DHA) are independently associated with increased risk of death from coronary heart disease (CHD). In randomized secondary prevention trials, fish or fish oil have been demonstrated to reduce total and CHD mortality at intakes of about 1 g/day. Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD.

METHODS

We conducted clinical and laboratory experiments to generate data necessary for the validation of the Omega-3 Index as a CHD risk predictor. The relationship between this putative marker and risk for CHD death, especially sudden cardiac death (SCD), was then evaluated in several published primary and secondary prevention studies.

RESULTS

The Omega-3 Index was inversely associated with risk for CHD mortality. An Omega-3 Index of > or = 8% was associated with the greatest cardioprotection, whereas an index of < or = 4% was associated with the least.

CONCLUSION

The Omega-3 Index may represent a novel, physiologically relevant, easily modified, independent, and graded risk factor for death from CHD that could have significant clinical utility.

Authors+Show Affiliations

Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke's Hospital, University of Missouri-KC School of Medicine, Kansas City, MO 64111, USA. vharris@saint-lukes.orgNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15208005

Citation

Harris, William S., and Clemens Von Schacky. "The Omega-3 Index: a New Risk Factor for Death From Coronary Heart Disease?" Preventive Medicine, vol. 39, no. 1, 2004, pp. 212-20.
Harris WS, Von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med. 2004;39(1):212-20.
Harris, W. S., & Von Schacky, C. (2004). The Omega-3 Index: a new risk factor for death from coronary heart disease? Preventive Medicine, 39(1), 212-20.
Harris WS, Von Schacky C. The Omega-3 Index: a New Risk Factor for Death From Coronary Heart Disease. Prev Med. 2004;39(1):212-20. PubMed PMID: 15208005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Omega-3 Index: a new risk factor for death from coronary heart disease? AU - Harris,William S, AU - Von Schacky,Clemens, PY - 2004/6/23/pubmed PY - 2004/10/13/medline PY - 2004/6/23/entrez SP - 212 EP - 20 JF - Preventive medicine JO - Prev Med VL - 39 IS - 1 N2 - BACKGROUND: Low intakes or blood levels of eicosapentaenoic and docosahexaenoic acids (EPA + DHA) are independently associated with increased risk of death from coronary heart disease (CHD). In randomized secondary prevention trials, fish or fish oil have been demonstrated to reduce total and CHD mortality at intakes of about 1 g/day. Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD. METHODS: We conducted clinical and laboratory experiments to generate data necessary for the validation of the Omega-3 Index as a CHD risk predictor. The relationship between this putative marker and risk for CHD death, especially sudden cardiac death (SCD), was then evaluated in several published primary and secondary prevention studies. RESULTS: The Omega-3 Index was inversely associated with risk for CHD mortality. An Omega-3 Index of > or = 8% was associated with the greatest cardioprotection, whereas an index of < or = 4% was associated with the least. CONCLUSION: The Omega-3 Index may represent a novel, physiologically relevant, easily modified, independent, and graded risk factor for death from CHD that could have significant clinical utility. SN - 0091-7435 UR - https://www.unboundmedicine.com/medline/citation/15208005/The_Omega_3_Index:_a_new_risk_factor_for_death_from_coronary_heart_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091743504000878 DB - PRIME DP - Unbound Medicine ER -