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Impaired fasting glucose vs. glucose intolerance in pre-menopausal women: distinct metabolic entities and cardiovascular disease risk?
Diabet Med. 2004 Jul; 21(7):730-7.DM

Abstract

BACKGROUND

Impaired glucose tolerance (IGT) is associated with an increased cardiovascular disease risk. Less is known about cardiovascular disease risk among subjects with impaired fasting glucose (IFG) or with combined IFG and IGT.

AIMS

To compare body composition, body fat distribution, plasma glucose-insulin homeostasis and plasma lipid-lipoprotein profile between pre-menopausal women having either a normal glucose tolerance (NGT), isolated IFG, isolated IGT or combined IFG and IGT.

METHODS

Three hundred and thirty-four women with NGT, 11 women with IFG, 35 women with IGT and 10 women with both IFG and IGT were studied.

RESULTS

Women with IFG were characterized by a higher visceral adipose tissue (AT) accumulation than women with NGT (P < 0.05). Also, they were characterized by a higher subcutaneous AT area and by higher body fat mass than NGT and IGT women (P < 0.05). However, their lipid-lipoprotein profile was comparable with that of NGT women, except for reduced HDL-cholesterol concentrations (P < 0.05). After adjustment for visceral AT, women with IFG had lower total cholesterol, LDL-cholesterol and apolipoprotein B (apoB) levels than the three other groups. They also had lower HDL(2)-cholesterol than NGT women and lower total cholesterol/HDL-cholesterol ratio than IGT women. Women with IGT showed higher triglyceride and apoB concentrations and a higher total cholesterol/HDL-cholesterol ratio than women with NGT (P < 0.05). Overall, women with combined IFG and IGT showed body fatness characteristics and alterations in their metabolic risk profile which were essentially similar to women with isolated IGT.

CONCLUSIONS

These results indicate that there are significant differences in anthropometric and metabolic variables between pre-menopausal women with IFG vs. IGT and that the association between body fatness-body fat distribution indices and the metabolic profile may differ between IFG and IGT women.

Authors+Show Affiliations

Department of Food Science and Nutrition, Laval University, Ste-Foy (Quebec) G1K 7P4, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15209766

Citation

Piché, M E., et al. "Impaired Fasting Glucose Vs. Glucose Intolerance in Pre-menopausal Women: Distinct Metabolic Entities and Cardiovascular Disease Risk?" Diabetic Medicine : a Journal of the British Diabetic Association, vol. 21, no. 7, 2004, pp. 730-7.
Piché ME, Després JP, Pascot A, et al. Impaired fasting glucose vs. glucose intolerance in pre-menopausal women: distinct metabolic entities and cardiovascular disease risk? Diabet Med. 2004;21(7):730-7.
Piché, M. E., Després, J. P., Pascot, A., Nadeau, A., Tremblay, A., Weisnagel, S. J., Bergeron, J., & Lemieux, S. (2004). Impaired fasting glucose vs. glucose intolerance in pre-menopausal women: distinct metabolic entities and cardiovascular disease risk? Diabetic Medicine : a Journal of the British Diabetic Association, 21(7), 730-7.
Piché ME, et al. Impaired Fasting Glucose Vs. Glucose Intolerance in Pre-menopausal Women: Distinct Metabolic Entities and Cardiovascular Disease Risk. Diabet Med. 2004;21(7):730-7. PubMed PMID: 15209766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired fasting glucose vs. glucose intolerance in pre-menopausal women: distinct metabolic entities and cardiovascular disease risk? AU - Piché,M E, AU - Després,J P, AU - Pascot,A, AU - Nadeau,A, AU - Tremblay,A, AU - Weisnagel,S J, AU - Bergeron,J, AU - Lemieux,S, PY - 2004/6/24/pubmed PY - 2004/9/29/medline PY - 2004/6/24/entrez SP - 730 EP - 7 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 21 IS - 7 N2 - BACKGROUND: Impaired glucose tolerance (IGT) is associated with an increased cardiovascular disease risk. Less is known about cardiovascular disease risk among subjects with impaired fasting glucose (IFG) or with combined IFG and IGT. AIMS: To compare body composition, body fat distribution, plasma glucose-insulin homeostasis and plasma lipid-lipoprotein profile between pre-menopausal women having either a normal glucose tolerance (NGT), isolated IFG, isolated IGT or combined IFG and IGT. METHODS: Three hundred and thirty-four women with NGT, 11 women with IFG, 35 women with IGT and 10 women with both IFG and IGT were studied. RESULTS: Women with IFG were characterized by a higher visceral adipose tissue (AT) accumulation than women with NGT (P < 0.05). Also, they were characterized by a higher subcutaneous AT area and by higher body fat mass than NGT and IGT women (P < 0.05). However, their lipid-lipoprotein profile was comparable with that of NGT women, except for reduced HDL-cholesterol concentrations (P < 0.05). After adjustment for visceral AT, women with IFG had lower total cholesterol, LDL-cholesterol and apolipoprotein B (apoB) levels than the three other groups. They also had lower HDL(2)-cholesterol than NGT women and lower total cholesterol/HDL-cholesterol ratio than IGT women. Women with IGT showed higher triglyceride and apoB concentrations and a higher total cholesterol/HDL-cholesterol ratio than women with NGT (P < 0.05). Overall, women with combined IFG and IGT showed body fatness characteristics and alterations in their metabolic risk profile which were essentially similar to women with isolated IGT. CONCLUSIONS: These results indicate that there are significant differences in anthropometric and metabolic variables between pre-menopausal women with IFG vs. IGT and that the association between body fatness-body fat distribution indices and the metabolic profile may differ between IFG and IGT women. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15209766/Impaired_fasting_glucose_vs__glucose_intolerance_in_pre_menopausal_women:_distinct_metabolic_entities_and_cardiovascular_disease_risk L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=15209766.ui DB - PRIME DP - Unbound Medicine ER -