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Auto antibodies against oxidized low density lipoprotein in severe preeclampsia.
J Obstet Gynaecol Res. 2004 Jun; 30(3):188-92.JO

Abstract

BACKGROUND

To study autoantibody titres against oxidized low density lipoprotein in preeclamsia.

METHODS

Ten millimeters of heparinized blood samples were collected from 20 primigravidae with severe preeclamsia (study group) and 20 gestation-matched normotensive primigravidae (control group). Concentration of malondialdehyde, metabolite of lipid peroxidation were measured in sera by HPLC and autoantibodies against oxidized low density lipoproteins (obtained after oxidation with 2 mm CuSO(4)) were determined by ELISA. Statistical analysis was performed by Student's t-test and chi(2) test.

RESULTS

Mean triglyceride levels were significantly (P < 0.001) higher in the study group (193.20 +/- 31.16 mg/dL) compared to the control group (170.60 +/- 23.2 mg/dL). Mean plasma lipid per oxide levels were not significantly different between the study (4.45 +/- 1.28 mmol/mL) and control (3.88 +/- 0.99 mmol/mL) groups. The majority of women in both groups had low antibody titres (<1.32) against low density lipoprotein. Six women (30%) of the study group and four (20%) of the control group had high autoantibody titres (>/=1.32). In preeclamptic women, diastolic blood pressure, the amount of urinary protein excretion and the plasma level of urea were significantly higher (P < 0.05) in patients with higher auto antibody titre.

CONCLUSION

Titres of autoantibodies to oxidized low density lipoprotein were similar in normotensive and preeclamptic women. In preeclamptic women, titres correlated positively with the severity of preeclampsia.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandhigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15210040

Citation

Jain, Meenakshi, et al. "Auto Antibodies Against Oxidized Low Density Lipoprotein in Severe Preeclampsia." The Journal of Obstetrics and Gynaecology Research, vol. 30, no. 3, 2004, pp. 188-92.
Jain M, Sawhney H, Aggarwal N, et al. Auto antibodies against oxidized low density lipoprotein in severe preeclampsia. J Obstet Gynaecol Res. 2004;30(3):188-92.
Jain, M., Sawhney, H., Aggarwal, N., Vashistha, K., & Majumdhar, S. (2004). Auto antibodies against oxidized low density lipoprotein in severe preeclampsia. The Journal of Obstetrics and Gynaecology Research, 30(3), 188-92.
Jain M, et al. Auto Antibodies Against Oxidized Low Density Lipoprotein in Severe Preeclampsia. J Obstet Gynaecol Res. 2004;30(3):188-92. PubMed PMID: 15210040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Auto antibodies against oxidized low density lipoprotein in severe preeclampsia. AU - Jain,Meenakshi, AU - Sawhney,Harjeet, AU - Aggarwal,Neelam, AU - Vashistha,Kala, AU - Majumdhar,Siddarth, PY - 2004/6/24/pubmed PY - 2004/7/16/medline PY - 2004/6/24/entrez SP - 188 EP - 92 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 30 IS - 3 N2 - BACKGROUND: To study autoantibody titres against oxidized low density lipoprotein in preeclamsia. METHODS: Ten millimeters of heparinized blood samples were collected from 20 primigravidae with severe preeclamsia (study group) and 20 gestation-matched normotensive primigravidae (control group). Concentration of malondialdehyde, metabolite of lipid peroxidation were measured in sera by HPLC and autoantibodies against oxidized low density lipoproteins (obtained after oxidation with 2 mm CuSO(4)) were determined by ELISA. Statistical analysis was performed by Student's t-test and chi(2) test. RESULTS: Mean triglyceride levels were significantly (P < 0.001) higher in the study group (193.20 +/- 31.16 mg/dL) compared to the control group (170.60 +/- 23.2 mg/dL). Mean plasma lipid per oxide levels were not significantly different between the study (4.45 +/- 1.28 mmol/mL) and control (3.88 +/- 0.99 mmol/mL) groups. The majority of women in both groups had low antibody titres (<1.32) against low density lipoprotein. Six women (30%) of the study group and four (20%) of the control group had high autoantibody titres (>/=1.32). In preeclamptic women, diastolic blood pressure, the amount of urinary protein excretion and the plasma level of urea were significantly higher (P < 0.05) in patients with higher auto antibody titre. CONCLUSION: Titres of autoantibodies to oxidized low density lipoprotein were similar in normotensive and preeclamptic women. In preeclamptic women, titres correlated positively with the severity of preeclampsia. SN - 1341-8076 UR - https://www.unboundmedicine.com/medline/citation/15210040/Auto_antibodies_against_oxidized_low_density_lipoprotein_in_severe_preeclampsia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1341-8076&amp;date=2004&amp;volume=30&amp;issue=3&amp;spage=188 DB - PRIME DP - Unbound Medicine ER -