Tags

Type your tag names separated by a space and hit enter

Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice.
Acta Pharmacol Sin. 2004 Jul; 25(7):966-72.AP

Abstract

AIM

To evaluate the hypoglycemic efficacy of insulin liposomes coated by chitosan with different molecular weights and concentrations after oral administration in mice.

METHODS

Insulin-liposomes were prepared by reversed-phase evaporation. Chitosan coating was carried out by incubation of the liposomal suspensions with the chitosan solution. The hypoglycemic efficacies of chitosan-coated insulin liposomes were investigated by monitoring the blood glucose level using the glucose oxidase method after oral administration to healthy mice.

RESULTS

In all the insulin liposomes, the insulin liposomes coated by 0.2% chitosan (Mr 1000 kDa) showed a better hypoglycemic efficacy as compared with the other liposomes coated by chitosan. The minimum blood glucose level was 15.1%+/-6.0 % of the initial (n=6). The hypoglycemic efficacy lasted for 4 h after oral administration to mice.

CONCLUSION

Chitosan-coated liposomes could reduce tryptic digestion on insulin, and enhance enteral absorption of insulin. The molecular weights and concentrations of chitosan had significant effects on hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration to healthy mice.

Authors+Show Affiliations

Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15210073

Citation

Wu, Zheng-hong, et al. "Hypoglycemic Efficacy of Chitosan-coated Insulin Liposomes After Oral Administration in Mice." Acta Pharmacologica Sinica, vol. 25, no. 7, 2004, pp. 966-72.
Wu ZH, Ping QN, Wei Y, et al. Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice. Acta Pharmacol Sin. 2004;25(7):966-72.
Wu, Z. H., Ping, Q. N., Wei, Y., & Lai, J. M. (2004). Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice. Acta Pharmacologica Sinica, 25(7), 966-72.
Wu ZH, et al. Hypoglycemic Efficacy of Chitosan-coated Insulin Liposomes After Oral Administration in Mice. Acta Pharmacol Sin. 2004;25(7):966-72. PubMed PMID: 15210073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice. AU - Wu,Zheng-hong, AU - Ping,Qi-neng, AU - Wei,Yi, AU - Lai,Jia-ming, PY - 2004/6/24/pubmed PY - 2004/9/1/medline PY - 2004/6/24/entrez SP - 966 EP - 72 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 25 IS - 7 N2 - AIM: To evaluate the hypoglycemic efficacy of insulin liposomes coated by chitosan with different molecular weights and concentrations after oral administration in mice. METHODS: Insulin-liposomes were prepared by reversed-phase evaporation. Chitosan coating was carried out by incubation of the liposomal suspensions with the chitosan solution. The hypoglycemic efficacies of chitosan-coated insulin liposomes were investigated by monitoring the blood glucose level using the glucose oxidase method after oral administration to healthy mice. RESULTS: In all the insulin liposomes, the insulin liposomes coated by 0.2% chitosan (Mr 1000 kDa) showed a better hypoglycemic efficacy as compared with the other liposomes coated by chitosan. The minimum blood glucose level was 15.1%+/-6.0 % of the initial (n=6). The hypoglycemic efficacy lasted for 4 h after oral administration to mice. CONCLUSION: Chitosan-coated liposomes could reduce tryptic digestion on insulin, and enhance enteral absorption of insulin. The molecular weights and concentrations of chitosan had significant effects on hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration to healthy mice. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/15210073/Hypoglycemic_efficacy_of_chitosan_coated_insulin_liposomes_after_oral_administration_in_mice_ L2 - http://www.chinaphar.com/1671-4083/25/966.pdf DB - PRIME DP - Unbound Medicine ER -