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Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations.
Arch Neurol. 2004 Jun; 61(6):865-8.AN

Abstract

BACKGROUND

An elevated plasma homocysteine (Hcy) level has been prospectively associated with an increased risk of vascular and degenerative dementias. An Hcy elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hcy level in patients with PD is unknown.

OBJECTIVE

To determine if hyperhomocysteinemia in patients with PD is associated with depression or with cognitive or physical impairments.

DESIGN

Ninety-seven people with a mean (SD) PD duration of 3.6 (1.6) years completed the Beck Depression Inventory, a battery of 11 cognitive tests, and the motor and function components of the Unified Parkinson's Disease Rating Scale. Normalized scores for the affective, cognitive, and physical measures were compared between those with a normal Hcy level (n = 66) and those with hyperhomocysteinemia (n = 31) (Hcy level, >1.89 mg/L [>14 micro mol/L]), controlling for age, sex, disease duration, and treatment.

RESULTS

Subjects with an elevated Hcy level were slightly older (68 vs 62 years), but had similar plasma concentrations of vitamin B(12) and folate. Hyperhomocysteinemic patients were more depressed (P =.02) and had worse cognition (P<.01), but the physical measure did not differ.

CONCLUSIONS

Patients with PD and hyperhomocysteinemia are more likely to be depressed and to perform worse on neuropsychometric tasks compared with normohomocysteinemic patients. Further research is warranted to see if hyperhomocysteinemia is a reversible risk factor for neuropsychiatric burden in patients with PD.

Authors+Show Affiliations

Department of Neurology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. Padraig.osuilleabhain@UTSouthwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15210523

Citation

O'Suilleabhain, Padraig E., et al. "Elevated Plasma Homocysteine Level in Patients With Parkinson Disease: Motor, Affective, and Cognitive Associations." Archives of Neurology, vol. 61, no. 6, 2004, pp. 865-8.
O'Suilleabhain PE, Sung V, Hernandez C, et al. Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. Arch Neurol. 2004;61(6):865-8.
O'Suilleabhain, P. E., Sung, V., Hernandez, C., Lacritz, L., Dewey, R. B., Bottiglieri, T., & Diaz-Arrastia, R. (2004). Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. Archives of Neurology, 61(6), 865-8.
O'Suilleabhain PE, et al. Elevated Plasma Homocysteine Level in Patients With Parkinson Disease: Motor, Affective, and Cognitive Associations. Arch Neurol. 2004;61(6):865-8. PubMed PMID: 15210523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. AU - O'Suilleabhain,Padraig E, AU - Sung,Victor, AU - Hernandez,Carlos, AU - Lacritz,Laura, AU - Dewey,Richard B,Jr AU - Bottiglieri,Teodoro, AU - Diaz-Arrastia,Ramon, PY - 2004/6/24/pubmed PY - 2004/7/9/medline PY - 2004/6/24/entrez SP - 865 EP - 8 JF - Archives of neurology JO - Arch Neurol VL - 61 IS - 6 N2 - BACKGROUND: An elevated plasma homocysteine (Hcy) level has been prospectively associated with an increased risk of vascular and degenerative dementias. An Hcy elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hcy level in patients with PD is unknown. OBJECTIVE: To determine if hyperhomocysteinemia in patients with PD is associated with depression or with cognitive or physical impairments. DESIGN: Ninety-seven people with a mean (SD) PD duration of 3.6 (1.6) years completed the Beck Depression Inventory, a battery of 11 cognitive tests, and the motor and function components of the Unified Parkinson's Disease Rating Scale. Normalized scores for the affective, cognitive, and physical measures were compared between those with a normal Hcy level (n = 66) and those with hyperhomocysteinemia (n = 31) (Hcy level, >1.89 mg/L [>14 micro mol/L]), controlling for age, sex, disease duration, and treatment. RESULTS: Subjects with an elevated Hcy level were slightly older (68 vs 62 years), but had similar plasma concentrations of vitamin B(12) and folate. Hyperhomocysteinemic patients were more depressed (P =.02) and had worse cognition (P<.01), but the physical measure did not differ. CONCLUSIONS: Patients with PD and hyperhomocysteinemia are more likely to be depressed and to perform worse on neuropsychometric tasks compared with normohomocysteinemic patients. Further research is warranted to see if hyperhomocysteinemia is a reversible risk factor for neuropsychiatric burden in patients with PD. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/15210523/Elevated_plasma_homocysteine_level_in_patients_with_Parkinson_disease:_motor_affective_and_cognitive_associations_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.61.6.865 DB - PRIME DP - Unbound Medicine ER -