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A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease.
Neurobiol Aging. 2004 Sep; 25(8):1017-22.NA

Abstract

Interleukin-1 (IL-1) gene polymorphisms are associated with an increased risk of Alzheimer's disease (AD) and it has been suggested that altered immune responses of the brain may play a role in the pathogenesis of the disease. Here we investigated whether IL-1beta polymorphisms affected neuro-pathological features and clinical status of AD patients with autopsy confirmed diagnosis of the disease. AD patients (n=133) were genotyped for the polymorphic regions in the apolipoprotein E epsilon (APOE epsilon) and interleukin-1beta (IL-1beta) genes. APOE epsilon4 carriers showed increased neuritic amyloid plaques (NP) and neurofibrillary tangles (NFT). The IL-1beta +3953 polymorphism influenced survival in AD patients and those with the TT genotype and without the APOE epsilon4 allele showed the shortest cumulative survival. Patients with the +3953 IL-1beta T and without the APOE epsilon4 alleles had reduced NP and NFT, a delayed ages at onset and death, but a decreased duration of the disease. On the other hand a different polymorphism of the IL-1beta gene at position -511 did not influence any AD features. Our findings suggest that IL-1beta gene by affecting brain immune responses may influence the age at onset of the disease, survival and AD progression.

Authors+Show Affiliations

Department of Experimental Pathology, University of Bologna, Bologna, Italy. licastro@alma.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15212826

Citation

Licastro, Federico, et al. "A Polymorphism of the Interleukin-1 Beta Gene at Position +3953 Influences Progression and Neuro-pathological Hallmarks of Alzheimer's Disease." Neurobiology of Aging, vol. 25, no. 8, 2004, pp. 1017-22.
Licastro F, Veglia F, Chiappelli M, et al. A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease. Neurobiol Aging. 2004;25(8):1017-22.
Licastro, F., Veglia, F., Chiappelli, M., Grimaldi, L. M., & Masliah, E. (2004). A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease. Neurobiology of Aging, 25(8), 1017-22.
Licastro F, et al. A Polymorphism of the Interleukin-1 Beta Gene at Position +3953 Influences Progression and Neuro-pathological Hallmarks of Alzheimer's Disease. Neurobiol Aging. 2004;25(8):1017-22. PubMed PMID: 15212826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease. AU - Licastro,Federico, AU - Veglia,Fabrizio, AU - Chiappelli,Martina, AU - Grimaldi,Luigi Maria E, AU - Masliah,Eliezer, PY - 2003/06/13/received PY - 2003/10/17/revised PY - 2003/11/04/accepted PY - 2004/6/24/pubmed PY - 2004/10/5/medline PY - 2004/6/24/entrez SP - 1017 EP - 22 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 25 IS - 8 N2 - Interleukin-1 (IL-1) gene polymorphisms are associated with an increased risk of Alzheimer's disease (AD) and it has been suggested that altered immune responses of the brain may play a role in the pathogenesis of the disease. Here we investigated whether IL-1beta polymorphisms affected neuro-pathological features and clinical status of AD patients with autopsy confirmed diagnosis of the disease. AD patients (n=133) were genotyped for the polymorphic regions in the apolipoprotein E epsilon (APOE epsilon) and interleukin-1beta (IL-1beta) genes. APOE epsilon4 carriers showed increased neuritic amyloid plaques (NP) and neurofibrillary tangles (NFT). The IL-1beta +3953 polymorphism influenced survival in AD patients and those with the TT genotype and without the APOE epsilon4 allele showed the shortest cumulative survival. Patients with the +3953 IL-1beta T and without the APOE epsilon4 alleles had reduced NP and NFT, a delayed ages at onset and death, but a decreased duration of the disease. On the other hand a different polymorphism of the IL-1beta gene at position -511 did not influence any AD features. Our findings suggest that IL-1beta gene by affecting brain immune responses may influence the age at onset of the disease, survival and AD progression. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/15212826/A_polymorphism_of_the_interleukin_1_beta_gene_at_position_+3953_influences_progression_and_neuro_pathological_hallmarks_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197458003002240 DB - PRIME DP - Unbound Medicine ER -