Tags

Type your tag names separated by a space and hit enter

Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats.
Eur J Pharmacol. 2004 Jun 28; 494(2-3):161-5.EJ

Abstract

The present study was performed to examine the sedative effects of second-generation histamine H(1) receptor antagonist using power spectrum analysis in the rat. Similar to ketotifen, olopatadine caused a decrease in sleep latency at a dose of 50 mg/kg, while epinastine and cetirizine showed no significant effect even at a dose of 50 mg/kg. On the other hand, no significant difference was observed in the total times of wakefulness, non-rapid eye movement sleep and rapid eye movement sleep by any drugs used in the experiments. The number of sleep phases and interval between sleep phases were also unchanged by these drugs. Ketotifen and olopatadine inhibited [(3)H]mepyramine binding to rat brain homogenates in parallel with a decrease in sleep latency. No significant effect was observed with epinastine and cetirizine on [(3)H]mepyramine binding. These findings suggest that the differences in the central nervous system (CNS) depressant effect observed in second generation H(1) receptor antagonists may be due to their liability to penetrate into the CNS.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15212970

Citation

Shigemoto, Yuki, et al. "Effects of Second-generation Histamine H1 Receptor Antagonists On the Sleep-wakefulness Cycle in Rats." European Journal of Pharmacology, vol. 494, no. 2-3, 2004, pp. 161-5.
Shigemoto Y, Shinomiya K, Mio M, et al. Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats. Eur J Pharmacol. 2004;494(2-3):161-5.
Shigemoto, Y., Shinomiya, K., Mio, M., Azuma, N., & Kamei, C. (2004). Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats. European Journal of Pharmacology, 494(2-3), 161-5.
Shigemoto Y, et al. Effects of Second-generation Histamine H1 Receptor Antagonists On the Sleep-wakefulness Cycle in Rats. Eur J Pharmacol. 2004 Jun 28;494(2-3):161-5. PubMed PMID: 15212970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats. AU - Shigemoto,Yuki, AU - Shinomiya,Kazuaki, AU - Mio,Mitsunobu, AU - Azuma,Nobuhide, AU - Kamei,Chiaki, PY - 2004/01/15/received PY - 2004/04/28/revised PY - 2004/05/10/accepted PY - 2004/6/24/pubmed PY - 2005/2/16/medline PY - 2004/6/24/entrez SP - 161 EP - 5 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 494 IS - 2-3 N2 - The present study was performed to examine the sedative effects of second-generation histamine H(1) receptor antagonist using power spectrum analysis in the rat. Similar to ketotifen, olopatadine caused a decrease in sleep latency at a dose of 50 mg/kg, while epinastine and cetirizine showed no significant effect even at a dose of 50 mg/kg. On the other hand, no significant difference was observed in the total times of wakefulness, non-rapid eye movement sleep and rapid eye movement sleep by any drugs used in the experiments. The number of sleep phases and interval between sleep phases were also unchanged by these drugs. Ketotifen and olopatadine inhibited [(3)H]mepyramine binding to rat brain homogenates in parallel with a decrease in sleep latency. No significant effect was observed with epinastine and cetirizine on [(3)H]mepyramine binding. These findings suggest that the differences in the central nervous system (CNS) depressant effect observed in second generation H(1) receptor antagonists may be due to their liability to penetrate into the CNS. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15212970/Effects_of_second_generation_histamine_H1_receptor_antagonists_on_the_sleep_wakefulness_cycle_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014299904005047 DB - PRIME DP - Unbound Medicine ER -