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Prospective study of abdominal adiposity and gallstone disease in US men.
Am J Clin Nutr 2004; 80(1):38-44AJ

Abstract

BACKGROUND

Obesity is an established risk factor for gallstones, but whether abdominal adiposity contributes independently to the risk, particularly in men, remains unclear.

OBJECTIVE

The purpose of the study was to examine the associations of abdominal circumference and waist-to-hip ratio, as measures of abdominal adiposity, with the risk of symptomatic gallstone disease in men.

DESIGN

We prospectively studied measures of abdominal obesity in relation to the incidence of symptomatic gallstone disease in a cohort of 29 847 men who were free of prior gallstone disease and who provided complete data on waist and hip circumferences. Data on weight, height, and waist and hip circumferences were collected in 1986 and in 1987 through self-administered questionnaires. As part of the Health Professionals Follow-Up Study, men reported newly diagnosed symptomatic gallstone disease on questionnaires mailed to them every 2 y.

RESULTS

We documented 1117 new cases of symptomatic gallstone disease during 264 185 person-years of follow-up. After adjustment for body mass index and other known or suspected risk factors for gallstones, men with a height-adjusted waist circumference > or = 102.6 cm (40.4 in) had a relative risk of 2.29 (95% CI: 1.69, 3.11; P for trend < 0.001) compared with men with a height-adjusted waist circumference < 86.4 cm (34 in). Men with a waist-to-hip ratio > or = 0.99 had a multivariate relative risk of 1.78 (1.38, 2.28; P for trend < 0.001) compared with men with a waist-to-hip ratio < 0.89.

CONCLUSIONS

Our data suggest the presence of a significant association between abdominal adiposity and the incidence of symptomatic gallstone disease. As measures of abdominal adiposity, abdominal circumference and waist-to-hip ratio predict the risk of developing gallstones independently of body mass index.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. hpcjt@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15213025

Citation

Tsai, Chung-Jyi, et al. "Prospective Study of Abdominal Adiposity and Gallstone Disease in US Men." The American Journal of Clinical Nutrition, vol. 80, no. 1, 2004, pp. 38-44.
Tsai CJ, Leitzmann MF, Willett WC, et al. Prospective study of abdominal adiposity and gallstone disease in US men. Am J Clin Nutr. 2004;80(1):38-44.
Tsai, C. J., Leitzmann, M. F., Willett, W. C., & Giovannucci, E. L. (2004). Prospective study of abdominal adiposity and gallstone disease in US men. The American Journal of Clinical Nutrition, 80(1), pp. 38-44.
Tsai CJ, et al. Prospective Study of Abdominal Adiposity and Gallstone Disease in US Men. Am J Clin Nutr. 2004;80(1):38-44. PubMed PMID: 15213025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of abdominal adiposity and gallstone disease in US men. AU - Tsai,Chung-Jyi, AU - Leitzmann,Michael F, AU - Willett,Walter C, AU - Giovannucci,Edward L, PY - 2004/6/24/pubmed PY - 2004/7/14/medline PY - 2004/6/24/entrez SP - 38 EP - 44 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 1 N2 - BACKGROUND: Obesity is an established risk factor for gallstones, but whether abdominal adiposity contributes independently to the risk, particularly in men, remains unclear. OBJECTIVE: The purpose of the study was to examine the associations of abdominal circumference and waist-to-hip ratio, as measures of abdominal adiposity, with the risk of symptomatic gallstone disease in men. DESIGN: We prospectively studied measures of abdominal obesity in relation to the incidence of symptomatic gallstone disease in a cohort of 29 847 men who were free of prior gallstone disease and who provided complete data on waist and hip circumferences. Data on weight, height, and waist and hip circumferences were collected in 1986 and in 1987 through self-administered questionnaires. As part of the Health Professionals Follow-Up Study, men reported newly diagnosed symptomatic gallstone disease on questionnaires mailed to them every 2 y. RESULTS: We documented 1117 new cases of symptomatic gallstone disease during 264 185 person-years of follow-up. After adjustment for body mass index and other known or suspected risk factors for gallstones, men with a height-adjusted waist circumference > or = 102.6 cm (40.4 in) had a relative risk of 2.29 (95% CI: 1.69, 3.11; P for trend < 0.001) compared with men with a height-adjusted waist circumference < 86.4 cm (34 in). Men with a waist-to-hip ratio > or = 0.99 had a multivariate relative risk of 1.78 (1.38, 2.28; P for trend < 0.001) compared with men with a waist-to-hip ratio < 0.89. CONCLUSIONS: Our data suggest the presence of a significant association between abdominal adiposity and the incidence of symptomatic gallstone disease. As measures of abdominal adiposity, abdominal circumference and waist-to-hip ratio predict the risk of developing gallstones independently of body mass index. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15213025/Prospective_study_of_abdominal_adiposity_and_gallstone_disease_in_US_men_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.1.38 DB - PRIME DP - Unbound Medicine ER -