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Frequent nut consumption and decreased risk of cholecystectomy in women.
Am J Clin Nutr. 2004 Jul; 80(1):76-81.AJ

Abstract

BACKGROUND

Gallstone disease is a major source of morbidity in the developed countries. Nuts are rich in several compounds that may protect against gallstone disease.

OBJECTIVE

The association between nut intake and cholecystectomy was examined in a large cohort of women.

DESIGN

We prospectively studied nut (peanuts, other nuts, and peanut butter) consumption in relation to the risk of cholecystectomy in a cohort of 80,718 women from the Nurses' Health Study who were 30-55 y old in 1980 and had no history of gallstone disease. As part of the Nurses' Health Study, the women reported on questionnaires mailed to them every 2 y both their consumption of nuts and whether they had undergone cholecystectomy. The women were followed through 2000.

RESULTS

During 1,393,256 person-years of follow-up from 1980 to 2000, we documented 7831 cholecystectomies. After adjustment for age and other known or suspected risk factors, women who consumed > or =5 units of nuts (1 unit = 1 oz or 28.6 g nuts)/wk (frequent consumption) had a significantly lower risk of cholecystectomy (relative risk: 0.75; 95% CI: 0.66, 0.85; P for trend < 0.0001) than did women who never ate nuts or who ate <1 unit/mo (rare consumption). Further adjustment for fat consumption (saturated fat, trans fat, polyunsaturated fat, and monounsaturated fat) did not materially alter the relation. In analyses examining consumption of peanuts and other nuts separately, both were associated with a lower risk of cholecystectomy.

CONCLUSION

In women, frequent nut consumption is associated with a reduced risk of cholecystectomy.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. hpcjt@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15213031

Citation

Tsai, Chung-Jyi, et al. "Frequent Nut Consumption and Decreased Risk of Cholecystectomy in Women." The American Journal of Clinical Nutrition, vol. 80, no. 1, 2004, pp. 76-81.
Tsai CJ, Leitzmann MF, Hu FB, et al. Frequent nut consumption and decreased risk of cholecystectomy in women. Am J Clin Nutr. 2004;80(1):76-81.
Tsai, C. J., Leitzmann, M. F., Hu, F. B., Willett, W. C., & Giovannucci, E. L. (2004). Frequent nut consumption and decreased risk of cholecystectomy in women. The American Journal of Clinical Nutrition, 80(1), 76-81.
Tsai CJ, et al. Frequent Nut Consumption and Decreased Risk of Cholecystectomy in Women. Am J Clin Nutr. 2004;80(1):76-81. PubMed PMID: 15213031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequent nut consumption and decreased risk of cholecystectomy in women. AU - Tsai,Chung-Jyi, AU - Leitzmann,Michael F, AU - Hu,Frank B, AU - Willett,Walter C, AU - Giovannucci,Edward L, PY - 2004/6/24/pubmed PY - 2004/7/14/medline PY - 2004/6/24/entrez SP - 76 EP - 81 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 1 N2 - BACKGROUND: Gallstone disease is a major source of morbidity in the developed countries. Nuts are rich in several compounds that may protect against gallstone disease. OBJECTIVE: The association between nut intake and cholecystectomy was examined in a large cohort of women. DESIGN: We prospectively studied nut (peanuts, other nuts, and peanut butter) consumption in relation to the risk of cholecystectomy in a cohort of 80,718 women from the Nurses' Health Study who were 30-55 y old in 1980 and had no history of gallstone disease. As part of the Nurses' Health Study, the women reported on questionnaires mailed to them every 2 y both their consumption of nuts and whether they had undergone cholecystectomy. The women were followed through 2000. RESULTS: During 1,393,256 person-years of follow-up from 1980 to 2000, we documented 7831 cholecystectomies. After adjustment for age and other known or suspected risk factors, women who consumed > or =5 units of nuts (1 unit = 1 oz or 28.6 g nuts)/wk (frequent consumption) had a significantly lower risk of cholecystectomy (relative risk: 0.75; 95% CI: 0.66, 0.85; P for trend < 0.0001) than did women who never ate nuts or who ate <1 unit/mo (rare consumption). Further adjustment for fat consumption (saturated fat, trans fat, polyunsaturated fat, and monounsaturated fat) did not materially alter the relation. In analyses examining consumption of peanuts and other nuts separately, both were associated with a lower risk of cholecystectomy. CONCLUSION: In women, frequent nut consumption is associated with a reduced risk of cholecystectomy. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15213031/Frequent_nut_consumption_and_decreased_risk_of_cholecystectomy_in_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.1.76 DB - PRIME DP - Unbound Medicine ER -