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Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes.
J Occup Environ Med. 2004 Jun; 46(6):528-37.JO

Abstract

A cross-sectional analysis was performed to evaluate associations of polymorphisms in the vitamin D receptor (VDR), delta-aminolevulinic acid dehydratase (ALAD), and endothelial nitric oxide synthase (eNOS) genes with patella lead concentrations in 652 lead workers in the Republic of Korea. There was a wide range of patella lead (from below detection limit to 946 microg Pb/g bone mineral), with a mean (standard deviation) of 75.2 (101.0). There were no associations of ALAD or eNOS genotypes with patella lead, but workers with the VDR B allele had significantly (P value < 0.05) higher patella lead (on average, 25% or approximately 6.6 microg Pb/g bone mineral) than lead workers with the VDR bb genotype. There was evidence that the relation between age and patella lead was modified by both the VDR and eNOS genotypes.

Authors+Show Affiliations

Theppeang K
Departments of Environmental Health Sciences, Johns Hopkins School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland, USA.
Schwartz BS
No affiliation info available
Lee BK
No affiliation info available
Lustberg ME
No affiliation info available
Silbergeld EK
No affiliation info available
Kelsey KT
No affiliation info available
Parsons PJ
No affiliation info available
Todd AC
No affiliation info available

MeSH

AdultAge FactorsAgedBone DensityFemaleGenotypeHumansKoreaLeadLead PoisoningLinear ModelsLongitudinal StudiesMaleMiddle AgedNitric Oxide SynthaseOccupational ExposurePatellaPolymorphism, GeneticPorphobilinogen SynthaseReceptors, CalcitriolSpectrometry, X-Ray Emission

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15213514

Citation

Theppeang, Keson, et al. "Associations of Patella Lead With Polymorphisms in the Vitamin D Receptor, Delta-aminolevulinic Acid Dehydratase and Endothelial Nitric Oxide Synthase Genes." Journal of Occupational and Environmental Medicine, vol. 46, no. 6, 2004, pp. 528-37.
Theppeang K, Schwartz BS, Lee BK, et al. Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes. J Occup Environ Med. 2004;46(6):528-37.
Theppeang, K., Schwartz, B. S., Lee, B. K., Lustberg, M. E., Silbergeld, E. K., Kelsey, K. T., Parsons, P. J., & Todd, A. C. (2004). Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes. Journal of Occupational and Environmental Medicine, 46(6), 528-37.
Theppeang K, et al. Associations of Patella Lead With Polymorphisms in the Vitamin D Receptor, Delta-aminolevulinic Acid Dehydratase and Endothelial Nitric Oxide Synthase Genes. J Occup Environ Med. 2004;46(6):528-37. PubMed PMID: 15213514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes. AU - Theppeang,Keson, AU - Schwartz,Brian S, AU - Lee,Byung-Kook, AU - Lustberg,Mark E, AU - Silbergeld,Ellen K, AU - Kelsey,Karl T, AU - Parsons,Patrick J, AU - Todd,Andrew C, PY - 2004/6/24/pubmed PY - 2004/9/24/medline PY - 2004/6/24/entrez SP - 528 EP - 37 JF - Journal of occupational and environmental medicine JO - J Occup Environ Med VL - 46 IS - 6 N2 - A cross-sectional analysis was performed to evaluate associations of polymorphisms in the vitamin D receptor (VDR), delta-aminolevulinic acid dehydratase (ALAD), and endothelial nitric oxide synthase (eNOS) genes with patella lead concentrations in 652 lead workers in the Republic of Korea. There was a wide range of patella lead (from below detection limit to 946 microg Pb/g bone mineral), with a mean (standard deviation) of 75.2 (101.0). There were no associations of ALAD or eNOS genotypes with patella lead, but workers with the VDR B allele had significantly (P value < 0.05) higher patella lead (on average, 25% or approximately 6.6 microg Pb/g bone mineral) than lead workers with the VDR bb genotype. There was evidence that the relation between age and patella lead was modified by both the VDR and eNOS genotypes. SN - 1076-2752 UR - https://www.unboundmedicine.com/medline/citation/15213514/Associations_of_patella_lead_with_polymorphisms_in_the_vitamin_D_receptor_delta_aminolevulinic_acid_dehydratase_and_endothelial_nitric_oxide_synthase_genes_ DB - PRIME DP - Unbound Medicine ER -
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