Tags

Type your tag names separated by a space and hit enter

Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women.
Eur J Clin Nutr. 2004 Dec; 58(12):1635-42.EJ

Abstract

OBJECTIVE

To confirm the results of an earlier study showing premenopausal equol excretors to have hormone profiles associated with reduced breast cancer risk, and to investigate whether equol excretion status and plasma hormone concentrations can be influenced by consumption of probiotics.

DESIGN

A randomized, single-blinded, placebo-controlled, parallel-arm trial.

SUBJECTS

In all, 34 of the initially enrolled 37 subjects completed all requirements.

INTERVENTION

All subjects were followed for two full menstrual cycles and the first seven days of a third cycle. During menstrual cycle 1, plasma concentrations of estradiol (E(2)), estrone (E(1)), estrone-sulfate (E(1)-S), testosterone (T), androstenedione (A), dehydroepiandrosterone-sulfate (DHEA-S), and sex-hormone-binding globulin (SHBG) were measured on cycle day 2, 3, or 4, and urinary equol measured on day 7 after a 4-day soy challenge. Subjects then received either probiotic capsules (containing Lactobacillus acidophilus and Bifidobacterium longum) or placebo capsules through day 7 of menstrual cycle 3, at which time both the plasma hormone concentrations and the post-soy challenge urinary equol measurements were repeated.

RESULTS

During menstrual cycle 1, equol excretors and non-excretors were not significantly different with respect to subject characteristics, diet, or hormone concentrations. Significant inverse correlations were found between E(2) and body mass index (BMI) (P=0.02), SHBG and BMI (P=0.01), DHEA-S and dietary fiber (P=0.04), and A and protein:carbohydrate ratio (P=0.02). Probiotic consumption failed to significantly alter equol excretor status or hormone concentrations during menstrual cycle 3, although there were trends towards decreased concentrations of T (P=0.14) and SHBG (P=0.10) in the probiotic group.

CONCLUSIONS

We were unable to verify a previously reported finding of premenopausal equol excretors having plasma hormone concentrations different from those of nonexcretors. Furthermore, a 2-month intervention with probiotic capsules did not significantly alter equol excretion or plasma hormone concentrations.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15213709

Citation

Bonorden, M J L., et al. "Consumption of Lactobacillus Acidophilus and Bifidobacterium Longum Do Not Alter Urinary Equol Excretion and Plasma Reproductive Hormones in Premenopausal Women." European Journal of Clinical Nutrition, vol. 58, no. 12, 2004, pp. 1635-42.
Bonorden MJ, Greany KA, Wangen KE, et al. Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women. Eur J Clin Nutr. 2004;58(12):1635-42.
Bonorden, M. J., Greany, K. A., Wangen, K. E., Phipps, W. R., Feirtag, J., Adlercreutz, H., & Kurzer, M. S. (2004). Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women. European Journal of Clinical Nutrition, 58(12), 1635-42.
Bonorden MJ, et al. Consumption of Lactobacillus Acidophilus and Bifidobacterium Longum Do Not Alter Urinary Equol Excretion and Plasma Reproductive Hormones in Premenopausal Women. Eur J Clin Nutr. 2004;58(12):1635-42. PubMed PMID: 15213709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women. AU - Bonorden,M J L, AU - Greany,K A, AU - Wangen,K E, AU - Phipps,W R, AU - Feirtag,J, AU - Adlercreutz,H, AU - Kurzer,M S, PY - 2004/6/24/pubmed PY - 2005/3/11/medline PY - 2004/6/24/entrez SP - 1635 EP - 42 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 12 N2 - OBJECTIVE: To confirm the results of an earlier study showing premenopausal equol excretors to have hormone profiles associated with reduced breast cancer risk, and to investigate whether equol excretion status and plasma hormone concentrations can be influenced by consumption of probiotics. DESIGN: A randomized, single-blinded, placebo-controlled, parallel-arm trial. SUBJECTS: In all, 34 of the initially enrolled 37 subjects completed all requirements. INTERVENTION: All subjects were followed for two full menstrual cycles and the first seven days of a third cycle. During menstrual cycle 1, plasma concentrations of estradiol (E(2)), estrone (E(1)), estrone-sulfate (E(1)-S), testosterone (T), androstenedione (A), dehydroepiandrosterone-sulfate (DHEA-S), and sex-hormone-binding globulin (SHBG) were measured on cycle day 2, 3, or 4, and urinary equol measured on day 7 after a 4-day soy challenge. Subjects then received either probiotic capsules (containing Lactobacillus acidophilus and Bifidobacterium longum) or placebo capsules through day 7 of menstrual cycle 3, at which time both the plasma hormone concentrations and the post-soy challenge urinary equol measurements were repeated. RESULTS: During menstrual cycle 1, equol excretors and non-excretors were not significantly different with respect to subject characteristics, diet, or hormone concentrations. Significant inverse correlations were found between E(2) and body mass index (BMI) (P=0.02), SHBG and BMI (P=0.01), DHEA-S and dietary fiber (P=0.04), and A and protein:carbohydrate ratio (P=0.02). Probiotic consumption failed to significantly alter equol excretor status or hormone concentrations during menstrual cycle 3, although there were trends towards decreased concentrations of T (P=0.14) and SHBG (P=0.10) in the probiotic group. CONCLUSIONS: We were unable to verify a previously reported finding of premenopausal equol excretors having plasma hormone concentrations different from those of nonexcretors. Furthermore, a 2-month intervention with probiotic capsules did not significantly alter equol excretion or plasma hormone concentrations. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15213709/Consumption_of_Lactobacillus_acidophilus_and_Bifidobacterium_longum_do_not_alter_urinary_equol_excretion_and_plasma_reproductive_hormones_in_premenopausal_women_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602020 DB - PRIME DP - Unbound Medicine ER -