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Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum.
J Infect Dis. 2004 Jul 15; 190(2):335-40.JI

Abstract

BACKGROUND

Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis antibodies in maternal-infant paired sera from 1999-2000.

METHODS

Antibodies to pertussis toxin (PT), filamentous hemagglutinin (FHA), and fimbrial proteins (FIM) were measured by validated IgG-specific enzyme-linked immunosorbant assay (ELISA) in 64 maternal-umbilical cord serum pairs and in 61 of 64 infant sera. Geometric mean concentrations (GMCs) of pertussis antibodies and cord : maternal GMC ratios were calculated.

RESULTS

Mean maternal age and gestation were 29.7 years (range, 19-42) and 39.3 weeks (range, 35.6-40.9), and 81% of mothers were white. GMCs of maternal antibodies at delivery (ELISA units/mL) were 2.4 for PT, 6.9 for FHA, and 13 for FIM. Cord GMCs were 169%, 178%, and 157% of maternal delivery values for PT, FHA, and FIM, respectively, demonstrating active placental transfer (P<.001). Pertussis-specific IgG values for each antigen decayed to below the threshold of detection by age 2 months.

CONCLUSIONS

Despite efficient placental transfer, low maternal pertussis antibody levels and their rapid decay in infant sera leave infants with little humoral protection against pertussis. These data support the rationale for maternal or neonatal immunization, with acellular pertussis vaccines, to prevent life-threatening pertussis in early infancy.

Authors+Show Affiliations

Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. chealy@bcm.tmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15216470

Citation

Healy, C Mary, et al. "Prevalence of Pertussis Antibodies in Maternal Delivery, Cord, and Infant Serum." The Journal of Infectious Diseases, vol. 190, no. 2, 2004, pp. 335-40.
Healy CM, Munoz FM, Rench MA, et al. Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum. J Infect Dis. 2004;190(2):335-40.
Healy, C. M., Munoz, F. M., Rench, M. A., Halasa, N. B., Edwards, K. M., & Baker, C. J. (2004). Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum. The Journal of Infectious Diseases, 190(2), 335-40.
Healy CM, et al. Prevalence of Pertussis Antibodies in Maternal Delivery, Cord, and Infant Serum. J Infect Dis. 2004 Jul 15;190(2):335-40. PubMed PMID: 15216470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of pertussis antibodies in maternal delivery, cord, and infant serum. AU - Healy,C Mary, AU - Munoz,Flor M, AU - Rench,Marcia A, AU - Halasa,Natasha B, AU - Edwards,Kathryn M, AU - Baker,Carol J, Y1 - 2004/06/14/ PY - 2003/10/28/received PY - 2003/12/05/accepted PY - 2004/6/25/pubmed PY - 2004/8/17/medline PY - 2004/6/25/entrez SP - 335 EP - 40 JF - The Journal of infectious diseases JO - J Infect Dis VL - 190 IS - 2 N2 - BACKGROUND: Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis antibodies in maternal-infant paired sera from 1999-2000. METHODS: Antibodies to pertussis toxin (PT), filamentous hemagglutinin (FHA), and fimbrial proteins (FIM) were measured by validated IgG-specific enzyme-linked immunosorbant assay (ELISA) in 64 maternal-umbilical cord serum pairs and in 61 of 64 infant sera. Geometric mean concentrations (GMCs) of pertussis antibodies and cord : maternal GMC ratios were calculated. RESULTS: Mean maternal age and gestation were 29.7 years (range, 19-42) and 39.3 weeks (range, 35.6-40.9), and 81% of mothers were white. GMCs of maternal antibodies at delivery (ELISA units/mL) were 2.4 for PT, 6.9 for FHA, and 13 for FIM. Cord GMCs were 169%, 178%, and 157% of maternal delivery values for PT, FHA, and FIM, respectively, demonstrating active placental transfer (P<.001). Pertussis-specific IgG values for each antigen decayed to below the threshold of detection by age 2 months. CONCLUSIONS: Despite efficient placental transfer, low maternal pertussis antibody levels and their rapid decay in infant sera leave infants with little humoral protection against pertussis. These data support the rationale for maternal or neonatal immunization, with acellular pertussis vaccines, to prevent life-threatening pertussis in early infancy. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/15216470/Prevalence_of_pertussis_antibodies_in_maternal_delivery_cord_and_infant_serum_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/421033 DB - PRIME DP - Unbound Medicine ER -