Tags

Type your tag names separated by a space and hit enter

A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report.
Hum Reprod. 2004 Sep; 19(9):2031-5.HR

Abstract

BACKGROUND

Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders.

METHODS

A randomized, controlled, single-blind trial was conducted in the Assisted Reproduction Unit, Institute of Reproductive Medicine, Kolkata, India. Thirty-eight women with a history of poor ovarian response to gonadotrophins were recruited. Thirteen women (Let-FSH group) received letrozole 2.5 mg daily from day 3-7, and recombinant FSH (rFSH) 75 IU/day on days 3 and 8; and 25 women (GnRH-ag-FSH group) underwent long GnRH agonist protocol and stimulated with rFSH (300-450 IU/day). Ovulation was triggered by 10,000 IU of HCG followed by IVF-embryo transfer. The main outcome measures were total dose of rFSH (IU/cycle), terminal estradiol (E2) (pg/ml), numbers of follicles, oocytes retrieved and transferable embryo, endometrial thickness (mm), and pregnancy rate.

RESULTS

Compared with the GnRH-ag-FSH group (2865 +/- 228 IU), the Let-FSH group (150 +/- 0 IU) received a significantly (P < 0.001) lower total dose of FSH. Except for terminal E2, which was significantly higher (P < 0.001) in the GnRH-ag-FSH group (380 +/- 46 pg/ml) than the Let-FSH group (227 +/- 45 pg/ml), the treatment outcomes in all other respects, including pregnancy rate, were statistically comparable.

CONCLUSIONS

Adjunctive use of letrozole may form an effective means of low-cost IVF protocol in poorly responding women.

Authors+Show Affiliations

Institute of Reproductive Medicine, Salt Lake, Kolkata 700091, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15217999

Citation

Goswami, S K., et al. "A Randomized Single-blind Controlled Trial of Letrozole as a Low-cost IVF Protocol in Women With Poor Ovarian Response: a Preliminary Report." Human Reproduction (Oxford, England), vol. 19, no. 9, 2004, pp. 2031-5.
Goswami SK, Das T, Chattopadhyay R, et al. A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. Hum Reprod. 2004;19(9):2031-5.
Goswami, S. K., Das, T., Chattopadhyay, R., Sawhney, V., Kumar, J., Chaudhury, K., Chakravarty, B. N., & Kabir, S. N. (2004). A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. Human Reproduction (Oxford, England), 19(9), 2031-5.
Goswami SK, et al. A Randomized Single-blind Controlled Trial of Letrozole as a Low-cost IVF Protocol in Women With Poor Ovarian Response: a Preliminary Report. Hum Reprod. 2004;19(9):2031-5. PubMed PMID: 15217999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. AU - Goswami,S K, AU - Das,T, AU - Chattopadhyay,R, AU - Sawhney,V, AU - Kumar,J, AU - Chaudhury,K, AU - Chakravarty,B N, AU - Kabir,S N, Y1 - 2004/06/24/ PY - 2004/6/26/pubmed PY - 2005/3/10/medline PY - 2004/6/26/entrez SP - 2031 EP - 5 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 19 IS - 9 N2 - BACKGROUND: Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders. METHODS: A randomized, controlled, single-blind trial was conducted in the Assisted Reproduction Unit, Institute of Reproductive Medicine, Kolkata, India. Thirty-eight women with a history of poor ovarian response to gonadotrophins were recruited. Thirteen women (Let-FSH group) received letrozole 2.5 mg daily from day 3-7, and recombinant FSH (rFSH) 75 IU/day on days 3 and 8; and 25 women (GnRH-ag-FSH group) underwent long GnRH agonist protocol and stimulated with rFSH (300-450 IU/day). Ovulation was triggered by 10,000 IU of HCG followed by IVF-embryo transfer. The main outcome measures were total dose of rFSH (IU/cycle), terminal estradiol (E2) (pg/ml), numbers of follicles, oocytes retrieved and transferable embryo, endometrial thickness (mm), and pregnancy rate. RESULTS: Compared with the GnRH-ag-FSH group (2865 +/- 228 IU), the Let-FSH group (150 +/- 0 IU) received a significantly (P < 0.001) lower total dose of FSH. Except for terminal E2, which was significantly higher (P < 0.001) in the GnRH-ag-FSH group (380 +/- 46 pg/ml) than the Let-FSH group (227 +/- 45 pg/ml), the treatment outcomes in all other respects, including pregnancy rate, were statistically comparable. CONCLUSIONS: Adjunctive use of letrozole may form an effective means of low-cost IVF protocol in poorly responding women. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15217999/A_randomized_single_blind_controlled_trial_of_letrozole_as_a_low_cost_IVF_protocol_in_women_with_poor_ovarian_response:_a_preliminary_report_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deh359 DB - PRIME DP - Unbound Medicine ER -