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Flattened cortisol rhythms in metastatic breast cancer patients.
Psychoneuroendocrinology. 2004 Sep; 29(8):1082-92.P

Abstract

Allostatic load, the physiological accumulation of the effects of chronic stressors, has been associated with multiple adverse health outcomes. Flattened diurnal cortisol rhythmicity is one of the prototypes of allostatic load, and has been shown to predict shorter survival among women with metastatic breast cancer. The current study compared diurnal cortisol slope in 17 breast cancer patients and 31 controls, and tested associations with variables previously found to be related to cortisol regulation, i.e, abdominal adiposity, perceived stress, social support, and explicit memory. Women with metastatic breast cancer had significantly flatter diurnal cortisol rhythms than did healthy controls. Patients with greater disease severity showed higher mean cortisol levels, smaller waist circumference, and a tendency toward flatter diurnal cortisol rhythms. There were no relations between cortisol slope and psychological or cognitive functioning among patients. In contrast, controls with flatter rhythms showed the expected allostatic load profile of larger waist circumference, poorer performance on explicit memory tasks, lower perceived social support, and a tendency toward higher perceived stress. These findings suggest that the cortisol diurnal slope may have important but different correlates in healthy women versus those with breast cancer.

Authors+Show Affiliations

Department of Psychiatry, University of Wisconsin Medical School, 6001 Research Park Blvd., Madison, WI 53719, USA. hcabercr@wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15219660

Citation

Abercrombie, Heather C., et al. "Flattened Cortisol Rhythms in Metastatic Breast Cancer Patients." Psychoneuroendocrinology, vol. 29, no. 8, 2004, pp. 1082-92.
Abercrombie HC, Giese-Davis J, Sephton S, et al. Flattened cortisol rhythms in metastatic breast cancer patients. Psychoneuroendocrinology. 2004;29(8):1082-92.
Abercrombie, H. C., Giese-Davis, J., Sephton, S., Epel, E. S., Turner-Cobb, J. M., & Spiegel, D. (2004). Flattened cortisol rhythms in metastatic breast cancer patients. Psychoneuroendocrinology, 29(8), 1082-92.
Abercrombie HC, et al. Flattened Cortisol Rhythms in Metastatic Breast Cancer Patients. Psychoneuroendocrinology. 2004;29(8):1082-92. PubMed PMID: 15219660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flattened cortisol rhythms in metastatic breast cancer patients. AU - Abercrombie,Heather C, AU - Giese-Davis,Janine, AU - Sephton,Sandra, AU - Epel,Elissa S, AU - Turner-Cobb,Julie M, AU - Spiegel,David, PY - 2003/06/19/received PY - 2003/11/07/revised PY - 2003/11/08/accepted PY - 2004/6/29/pubmed PY - 2004/10/20/medline PY - 2004/6/29/entrez SP - 1082 EP - 92 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 29 IS - 8 N2 - Allostatic load, the physiological accumulation of the effects of chronic stressors, has been associated with multiple adverse health outcomes. Flattened diurnal cortisol rhythmicity is one of the prototypes of allostatic load, and has been shown to predict shorter survival among women with metastatic breast cancer. The current study compared diurnal cortisol slope in 17 breast cancer patients and 31 controls, and tested associations with variables previously found to be related to cortisol regulation, i.e, abdominal adiposity, perceived stress, social support, and explicit memory. Women with metastatic breast cancer had significantly flatter diurnal cortisol rhythms than did healthy controls. Patients with greater disease severity showed higher mean cortisol levels, smaller waist circumference, and a tendency toward flatter diurnal cortisol rhythms. There were no relations between cortisol slope and psychological or cognitive functioning among patients. In contrast, controls with flatter rhythms showed the expected allostatic load profile of larger waist circumference, poorer performance on explicit memory tasks, lower perceived social support, and a tendency toward higher perceived stress. These findings suggest that the cortisol diurnal slope may have important but different correlates in healthy women versus those with breast cancer. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/15219660/Flattened_cortisol_rhythms_in_metastatic_breast_cancer_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S030645300300221X DB - PRIME DP - Unbound Medicine ER -