Tags

Type your tag names separated by a space and hit enter

Effects of low and moderate antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes.
Diabetes. 2004 Jul; 53(7):1798-806.D

Abstract

Antecedent moderate-intensity exercise has been shown to blunt autonomic, neuroendocrine, and metabolic counterregulatory responses to subsequent hypoglycemia in nondiabetic individuals. The aims of the current study were to determine 1) whether this occurs in type 1 diabetic patients and 2) whether the degree of blunting is dependent on exercise intensity. Twenty-seven type 1 diabetic patients (13 women and 14 men) were studied during a single-step, 2-h hyperinsulinemic (9 pmol x kg(-1) x min(-1))-hypoglycemic (approximately 2.8 mmol/l) clamp 1 day after two 90-min exercise bouts at 30% (n = 11) or at 50% (n = 11) Vo(2max) or after no prior stress (control subjects, n = 25). After prior exercise at both 30 and 50% Vo(2max), epinephrine (1,959 +/- 553 and 1,528 +/- 424 vs. 3,420 +/- 424 pmol/l, respectively; P < 0.05) and pancreatic polypeptide (97 +/- 32 and 98 +/- 8 vs. 223 +/- 32 pmol/l, respectively; P < 0.05) responses to subsequent hypoglycemia were significantly lower compared with those of control subjects. Endogenous glucose production was significantly lower, while glucose utilization and, consequently, the exogenous glucose infusion rate needed to maintain hypoglycemia were significantly greater after both exercise intensities compared with that of control subjects. Muscle sympathetic nerve activity was significantly reduced by prior exercise of both intensities at baseline (16 +/- 4 and 22 +/- 4 vs. 31 +/- 3 bursts/min) and during hypoglycemia (22 +/- 4 and 27 +/- 5 vs. 41 +/- 3 bursts/min) compared with that of control subjects (P < 0.05). Total hypoglycemic symptoms were also significantly lower (P < 0.05) in both exercise groups compared with the control group. In summary, repeated episodes of prolonged exercise of both low and moderate intensities blunted key autonomic (epinephrine and pancreatic polypeptide) and metabolic (endogenous glucose production and peripheral glucose uptake) counterregulatory responses to next-day hypoglycemia in type 1 diabetes.

Authors+Show Affiliations

Sandoval DA
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6303, USA. darleen.sandoval@vanderbilt.edu
Guy DL
No affiliation info available
Richardson MA
No affiliation info available
Ertl AC
No affiliation info available
Davis SN
No affiliation info available

MeSH

AdultBlood GlucoseCardiovascular SystemDiabetes Mellitus, Type 1ExerciseFemaleGlucoseHormonesHumansHypoglycemiaInsulinMaleMuscle, SkeletalSympathetic Nervous System

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15220204

Citation

Sandoval, Darleen A., et al. "Effects of Low and Moderate Antecedent Exercise On Counterregulatory Responses to Subsequent Hypoglycemia in Type 1 Diabetes." Diabetes, vol. 53, no. 7, 2004, pp. 1798-806.
Sandoval DA, Guy DL, Richardson MA, et al. Effects of low and moderate antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes. Diabetes. 2004;53(7):1798-806.
Sandoval, D. A., Guy, D. L., Richardson, M. A., Ertl, A. C., & Davis, S. N. (2004). Effects of low and moderate antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes. Diabetes, 53(7), 1798-806.
Sandoval DA, et al. Effects of Low and Moderate Antecedent Exercise On Counterregulatory Responses to Subsequent Hypoglycemia in Type 1 Diabetes. Diabetes. 2004;53(7):1798-806. PubMed PMID: 15220204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of low and moderate antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes. AU - Sandoval,Darleen A, AU - Guy,Deanna L Aftab, AU - Richardson,M Antoinette, AU - Ertl,Andrew C, AU - Davis,Stephen N, PY - 2004/6/29/pubmed PY - 2004/9/17/medline PY - 2004/6/29/entrez SP - 1798 EP - 806 JF - Diabetes JO - Diabetes VL - 53 IS - 7 N2 - Antecedent moderate-intensity exercise has been shown to blunt autonomic, neuroendocrine, and metabolic counterregulatory responses to subsequent hypoglycemia in nondiabetic individuals. The aims of the current study were to determine 1) whether this occurs in type 1 diabetic patients and 2) whether the degree of blunting is dependent on exercise intensity. Twenty-seven type 1 diabetic patients (13 women and 14 men) were studied during a single-step, 2-h hyperinsulinemic (9 pmol x kg(-1) x min(-1))-hypoglycemic (approximately 2.8 mmol/l) clamp 1 day after two 90-min exercise bouts at 30% (n = 11) or at 50% (n = 11) Vo(2max) or after no prior stress (control subjects, n = 25). After prior exercise at both 30 and 50% Vo(2max), epinephrine (1,959 +/- 553 and 1,528 +/- 424 vs. 3,420 +/- 424 pmol/l, respectively; P < 0.05) and pancreatic polypeptide (97 +/- 32 and 98 +/- 8 vs. 223 +/- 32 pmol/l, respectively; P < 0.05) responses to subsequent hypoglycemia were significantly lower compared with those of control subjects. Endogenous glucose production was significantly lower, while glucose utilization and, consequently, the exogenous glucose infusion rate needed to maintain hypoglycemia were significantly greater after both exercise intensities compared with that of control subjects. Muscle sympathetic nerve activity was significantly reduced by prior exercise of both intensities at baseline (16 +/- 4 and 22 +/- 4 vs. 31 +/- 3 bursts/min) and during hypoglycemia (22 +/- 4 and 27 +/- 5 vs. 41 +/- 3 bursts/min) compared with that of control subjects (P < 0.05). Total hypoglycemic symptoms were also significantly lower (P < 0.05) in both exercise groups compared with the control group. In summary, repeated episodes of prolonged exercise of both low and moderate intensities blunted key autonomic (epinephrine and pancreatic polypeptide) and metabolic (endogenous glucose production and peripheral glucose uptake) counterregulatory responses to next-day hypoglycemia in type 1 diabetes. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/15220204/Effects_of_low_and_moderate_antecedent_exercise_on_counterregulatory_responses_to_subsequent_hypoglycemia_in_type_1_diabetes_ DB - PRIME DP - Unbound Medicine ER -