Tags

Type your tag names separated by a space and hit enter

Induction of nerve growth factor mRNA in a rat dorsal root ganglion after application of a tourniquet.
Acta Neuropathol. 2004 Sep; 108(3):183-8.AN

Abstract

We investigated the mRNA levels of neurotrophins and neurotrophin receptors in a rat dorsal root ganglion (DRG), after tourniquet application to a hind limb, to identify the nerve-protective molecules that are induced immediately after peripheral nerve crush and play a part in the process leading to secondary events. No significant expression of nerve growth factor (NGF) mRNA or protein was observed in the control or contralateral DRG. NGF mRNA expression started within 2 h and NGF protein expression was observed in Schwann cells at 4 h after application of the tourniquet, due to termination of the neurotrophin supply from peripheral nerves. The levels of neurotrophin 3 mRNA were significantly increased in the DRGs on both sides at 1 and 2 h after tourniquet application, but no significant changes in brain-derived neurotrophic factor and neurotrophin 4/5 expression levels were observed in either the contralateral or ipsilateral DRG. The expression levels of neurotrophin receptors in the DRGs on both the contralateral and ipsilateral sides had decreased at 1 to 2 h after application of the tourniquet and had returned to the control levels at 4 h after tourniquet application.

Authors+Show Affiliations

Department of Legal Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. sumiko@fmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15221333

Citation

Abe, Sumiko, et al. "Induction of Nerve Growth Factor mRNA in a Rat Dorsal Root Ganglion After Application of a Tourniquet." Acta Neuropathologica, vol. 108, no. 3, 2004, pp. 183-8.
Abe S, Mizusawa I, Kanno K, et al. Induction of nerve growth factor mRNA in a rat dorsal root ganglion after application of a tourniquet. Acta Neuropathol. 2004;108(3):183-8.
Abe, S., Mizusawa, I., Kanno, K., Yabashi, A., Suto, M., Kuraya, M., Honda, T., & Hiraiwa, K. (2004). Induction of nerve growth factor mRNA in a rat dorsal root ganglion after application of a tourniquet. Acta Neuropathologica, 108(3), 183-8.
Abe S, et al. Induction of Nerve Growth Factor mRNA in a Rat Dorsal Root Ganglion After Application of a Tourniquet. Acta Neuropathol. 2004;108(3):183-8. PubMed PMID: 15221333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of nerve growth factor mRNA in a rat dorsal root ganglion after application of a tourniquet. AU - Abe,Sumiko, AU - Mizusawa,Ikubumi, AU - Kanno,Katsuyuki, AU - Yabashi,Atsuko, AU - Suto,Miwako, AU - Kuraya,Mikio, AU - Honda,Takashi, AU - Hiraiwa,Kouichi, Y1 - 2004/06/18/ PY - 2003/12/29/received PY - 2004/03/22/revised PY - 2004/03/22/accepted PY - 2004/6/29/pubmed PY - 2004/11/17/medline PY - 2004/6/29/entrez SP - 183 EP - 8 JF - Acta neuropathologica JO - Acta Neuropathol VL - 108 IS - 3 N2 - We investigated the mRNA levels of neurotrophins and neurotrophin receptors in a rat dorsal root ganglion (DRG), after tourniquet application to a hind limb, to identify the nerve-protective molecules that are induced immediately after peripheral nerve crush and play a part in the process leading to secondary events. No significant expression of nerve growth factor (NGF) mRNA or protein was observed in the control or contralateral DRG. NGF mRNA expression started within 2 h and NGF protein expression was observed in Schwann cells at 4 h after application of the tourniquet, due to termination of the neurotrophin supply from peripheral nerves. The levels of neurotrophin 3 mRNA were significantly increased in the DRGs on both sides at 1 and 2 h after tourniquet application, but no significant changes in brain-derived neurotrophic factor and neurotrophin 4/5 expression levels were observed in either the contralateral or ipsilateral DRG. The expression levels of neurotrophin receptors in the DRGs on both the contralateral and ipsilateral sides had decreased at 1 to 2 h after application of the tourniquet and had returned to the control levels at 4 h after tourniquet application. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/15221333/Induction_of_nerve_growth_factor_mRNA_in_a_rat_dorsal_root_ganglion_after_application_of_a_tourniquet_ L2 - https://dx.doi.org/10.1007/s00401-004-0870-y DB - PRIME DP - Unbound Medicine ER -