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Resistance training exercise and creatine in patients with Charcot-Marie-Tooth disease.
Muscle Nerve. 2004 Jul; 30(1):69-76.MN

Abstract

Resistance exercise and creatine supplementation independently improve strength and function in patients with certain neuromuscular diseases. The purpose of this study was to examine the effects of resistance training with and without creatine supplementation on muscle, strength, and function in patients with Charcot-Marie-Tooth (CMT) disease. Twenty patients with CMT consumed 5 g/day creatine or placebo while participating in resistance training for 12 weeks. Energy metabolites, muscle fiber type and size, strength, and timed activities of daily living were measured before and after training. There were no differences between creatine or placebo groups for any outcome. For the groups combined, exercise training increased type I muscle fiber diameter (48.2 +/- 14.2 microm vs. 55.4 +/- 14.8 microm), strength, and activities of daily living (ADL) times. Thus, patients respond to resistance training with muscle fiber adaptations, and improvements in strength and function. Creatine was not beneficial.

Authors+Show Affiliations

Department of Human Performance and Applied Exercise Science, West Virginia University, P.O. Box 9139, Morgantown, West Virginia 26506-9139, USA. rchetlin@hsc.wvu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15221881

Citation

Chetlin, Robert D., et al. "Resistance Training Exercise and Creatine in Patients With Charcot-Marie-Tooth Disease." Muscle & Nerve, vol. 30, no. 1, 2004, pp. 69-76.
Chetlin RD, Gutmann L, Tarnopolsky MA, et al. Resistance training exercise and creatine in patients with Charcot-Marie-Tooth disease. Muscle Nerve. 2004;30(1):69-76.
Chetlin, R. D., Gutmann, L., Tarnopolsky, M. A., Ullrich, I. H., & Yeater, R. A. (2004). Resistance training exercise and creatine in patients with Charcot-Marie-Tooth disease. Muscle & Nerve, 30(1), 69-76.
Chetlin RD, et al. Resistance Training Exercise and Creatine in Patients With Charcot-Marie-Tooth Disease. Muscle Nerve. 2004;30(1):69-76. PubMed PMID: 15221881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance training exercise and creatine in patients with Charcot-Marie-Tooth disease. AU - Chetlin,Robert D, AU - Gutmann,Laurie, AU - Tarnopolsky,Mark A, AU - Ullrich,Irma H, AU - Yeater,Rachel A, PY - 2004/6/29/pubmed PY - 2004/8/4/medline PY - 2004/6/29/entrez SP - 69 EP - 76 JF - Muscle & nerve JO - Muscle Nerve VL - 30 IS - 1 N2 - Resistance exercise and creatine supplementation independently improve strength and function in patients with certain neuromuscular diseases. The purpose of this study was to examine the effects of resistance training with and without creatine supplementation on muscle, strength, and function in patients with Charcot-Marie-Tooth (CMT) disease. Twenty patients with CMT consumed 5 g/day creatine or placebo while participating in resistance training for 12 weeks. Energy metabolites, muscle fiber type and size, strength, and timed activities of daily living were measured before and after training. There were no differences between creatine or placebo groups for any outcome. For the groups combined, exercise training increased type I muscle fiber diameter (48.2 +/- 14.2 microm vs. 55.4 +/- 14.8 microm), strength, and activities of daily living (ADL) times. Thus, patients respond to resistance training with muscle fiber adaptations, and improvements in strength and function. Creatine was not beneficial. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/15221881/Resistance_training_exercise_and_creatine_in_patients_with_Charcot_Marie_Tooth_disease_ L2 - https://doi.org/10.1002/mus.20078 DB - PRIME DP - Unbound Medicine ER -