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Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex.
J Comp Neurol 2004; 475(3):361-73JC

Abstract

Recordings of synaptic responses of pyramidal neurons to feedback (FB) inputs from higher to lower areas of visual cortex show that excitatory synaptic responses are only weakly opposed by disynaptic inhibition. Whether weak inhibition is preserved at high frequencies remains unknown. Whole-cell recordings were performed in pyramidal cells of mouse visual cortex to study the frequency dependence of excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) elicited by feedforward (FF) input from the primary visual cortex (V1) to the higher lateromedial area (LM) and by FB input from the LM to V1. EPSCs showed similar frequency dependencies in FF and FB pathways; the amplitudes decreased during stimulus trains, and the depression was larger at higher frequencies. IPSCs decreased during repetitive stimulation, and the depression increased at higher frequencies. At >20 Hz, the depression of IPSCs in the FB pathway was greater than in the FF pathway. Thus, unlike FF circuits, FB circuits provide balanced excitatory and inhibitory inputs across a wide range of frequencies. This property was shown to be critically important in cortical circuits that modulate the gain of pyramidal cell firing (Chance et al. [2002] Neuron 35:773-782).

Authors+Show Affiliations

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15221951

Citation

Dong, Hongwei, et al. "Differential Depression of Inhibitory Synaptic Responses in Feedforward and Feedback Circuits Between Different Areas of Mouse Visual Cortex." The Journal of Comparative Neurology, vol. 475, no. 3, 2004, pp. 361-73.
Dong H, Shao Z, Nerbonne JM, et al. Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex. J Comp Neurol. 2004;475(3):361-73.
Dong, H., Shao, Z., Nerbonne, J. M., & Burkhalter, A. (2004). Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex. The Journal of Comparative Neurology, 475(3), pp. 361-73.
Dong H, et al. Differential Depression of Inhibitory Synaptic Responses in Feedforward and Feedback Circuits Between Different Areas of Mouse Visual Cortex. J Comp Neurol. 2004 Jul 26;475(3):361-73. PubMed PMID: 15221951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex. AU - Dong,Hongwei, AU - Shao,Zhenwei, AU - Nerbonne,Jeanne M, AU - Burkhalter,Andreas, PY - 2004/6/29/pubmed PY - 2004/8/27/medline PY - 2004/6/29/entrez SP - 361 EP - 73 JF - The Journal of comparative neurology JO - J. Comp. Neurol. VL - 475 IS - 3 N2 - Recordings of synaptic responses of pyramidal neurons to feedback (FB) inputs from higher to lower areas of visual cortex show that excitatory synaptic responses are only weakly opposed by disynaptic inhibition. Whether weak inhibition is preserved at high frequencies remains unknown. Whole-cell recordings were performed in pyramidal cells of mouse visual cortex to study the frequency dependence of excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) elicited by feedforward (FF) input from the primary visual cortex (V1) to the higher lateromedial area (LM) and by FB input from the LM to V1. EPSCs showed similar frequency dependencies in FF and FB pathways; the amplitudes decreased during stimulus trains, and the depression was larger at higher frequencies. IPSCs decreased during repetitive stimulation, and the depression increased at higher frequencies. At >20 Hz, the depression of IPSCs in the FB pathway was greater than in the FF pathway. Thus, unlike FF circuits, FB circuits provide balanced excitatory and inhibitory inputs across a wide range of frequencies. This property was shown to be critically important in cortical circuits that modulate the gain of pyramidal cell firing (Chance et al. [2002] Neuron 35:773-782). SN - 0021-9967 UR - https://www.unboundmedicine.com/medline/citation/15221951/Differential_depression_of_inhibitory_synaptic_responses_in_feedforward_and_feedback_circuits_between_different_areas_of_mouse_visual_cortex_ L2 - https://doi.org/10.1002/cne.20164 DB - PRIME DP - Unbound Medicine ER -