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Changes in cerebral and autonomic activity heralding periodic limb movements in sleep.
Sleep Med. 2004 Jul; 5(4):407-12.SM

Abstract

BACKGROUND AND PURPOSE

Periodic limb movement disorder (PLMD) is frequently accompanied by awakenings or signs of EEG arousal. However, it is matter of debate whether EEG arousals trigger leg movements or both EEG arousal and leg movements are separate expressions of a common pathophysiological mechanism. Previous studies showed that cardiac and cerebral changes occur in association with periodic limb movements (PLMs), and that a combining increase in delta activity and in heart rate (HR) occurs before the onset of PLMs.

PATIENTS AND METHODS

This paper presents some preliminary data, obtained from a sample of 5 subjects with PLMD not associated to restless legs syndrome. To describe the temporal pattern of cardiac and EEG activities changes concomitant with PLMs in NREM sleep we used time frequency analysis technique.

RESULTS

PLM onset is heralded by a significant activation of HR and delta activity power, beginning 4.25 and 3 s respectively before PLMs onset, with PLMs onset and arousal onset falling together.

DISCUSSION

Delta and HR variations herald PLMs and activation of fast EEG frequencies. Such a stereotyped pattern is common in PLMs and in spontaneous or stimuli-induced arousals. Moreover a similar pattern seems to encompass the CAP phenomenon. The whole of these phenomena can be linked to the activity of a common brainstem system, which receives peripheral inputs, regulating the vascular, cardiac and respiratory activities and synchronizing them to cortical oscillations of EEG.

Authors+Show Affiliations

Center for Sleep Medicine, DISMR, Department of Motor Sciences, University of Genova, Ospedale S. Martino, Largo R. Benzi 10, I-16132 Genoa, Italy. franco.ferrillo@unige.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15223001

Citation

Ferrillo, Franco, et al. "Changes in Cerebral and Autonomic Activity Heralding Periodic Limb Movements in Sleep." Sleep Medicine, vol. 5, no. 4, 2004, pp. 407-12.
Ferrillo F, Beelke M, Canovaro P, et al. Changes in cerebral and autonomic activity heralding periodic limb movements in sleep. Sleep Med. 2004;5(4):407-12.
Ferrillo, F., Beelke, M., Canovaro, P., Watanabe, T., Aricò, D., Rizzo, P., Garbarino, S., Nobili, L., & De Carli, F. (2004). Changes in cerebral and autonomic activity heralding periodic limb movements in sleep. Sleep Medicine, 5(4), 407-12.
Ferrillo F, et al. Changes in Cerebral and Autonomic Activity Heralding Periodic Limb Movements in Sleep. Sleep Med. 2004;5(4):407-12. PubMed PMID: 15223001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in cerebral and autonomic activity heralding periodic limb movements in sleep. AU - Ferrillo,Franco, AU - Beelke,Manolo, AU - Canovaro,Paola, AU - Watanabe,Tsuyoshi, AU - Aricò,Debora, AU - Rizzo,Pierpaolo, AU - Garbarino,Sergio, AU - Nobili,Lino, AU - De Carli,Fabrizio, PY - 2002/12/01/received PY - 2003/10/15/accepted PY - 2004/6/30/pubmed PY - 2005/6/23/medline PY - 2004/6/30/entrez SP - 407 EP - 12 JF - Sleep medicine JO - Sleep Med VL - 5 IS - 4 N2 - BACKGROUND AND PURPOSE: Periodic limb movement disorder (PLMD) is frequently accompanied by awakenings or signs of EEG arousal. However, it is matter of debate whether EEG arousals trigger leg movements or both EEG arousal and leg movements are separate expressions of a common pathophysiological mechanism. Previous studies showed that cardiac and cerebral changes occur in association with periodic limb movements (PLMs), and that a combining increase in delta activity and in heart rate (HR) occurs before the onset of PLMs. PATIENTS AND METHODS: This paper presents some preliminary data, obtained from a sample of 5 subjects with PLMD not associated to restless legs syndrome. To describe the temporal pattern of cardiac and EEG activities changes concomitant with PLMs in NREM sleep we used time frequency analysis technique. RESULTS: PLM onset is heralded by a significant activation of HR and delta activity power, beginning 4.25 and 3 s respectively before PLMs onset, with PLMs onset and arousal onset falling together. DISCUSSION: Delta and HR variations herald PLMs and activation of fast EEG frequencies. Such a stereotyped pattern is common in PLMs and in spontaneous or stimuli-induced arousals. Moreover a similar pattern seems to encompass the CAP phenomenon. The whole of these phenomena can be linked to the activity of a common brainstem system, which receives peripheral inputs, regulating the vascular, cardiac and respiratory activities and synchronizing them to cortical oscillations of EEG. SN - 1389-9457 UR - https://www.unboundmedicine.com/medline/citation/15223001/Changes_in_cerebral_and_autonomic_activity_heralding_periodic_limb_movements_in_sleep_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389945704000206 DB - PRIME DP - Unbound Medicine ER -