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Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases.
Free Radic Biol Med. 2004 Aug 01; 37(3):304-17.FR

Abstract

Neurodegeneration in Parkinson's, Alzheimer's, and other neurodegenerative diseases seems to be multifactorial, in that a complex set of toxic reactions including inflammation, glutamatergic neurotoxicity, increases in iron and nitric oxide, depletion of endogenous antioxidants, reduced expression of trophic factors, dysfunction of the ubiquitin-proteasome system, and expression of proapoptotic proteins leads to the demise of neurons. Thus, the fundamental objective in neurodegeneration and neuroprotection research is to determine which of these factors constitutes the primary event, the sequence in which these events occur, and whether they act in concurrence in the pathogenic process. This has led to the current notion that drugs directed against a single target will be ineffective and rather a single drug or cocktail of drugs with pluripharmacological properties may be more suitable. Green tea catechin polyphenols, formerly thought to be simple radical scavengers, are now considered to invoke a spectrum of cellular mechanisms of action related to their neuroprotective activity. These include pharmacological activities like iron chelation, scavenging of radicals, activation of survival genes and cell signaling pathways, and regulation of mitochondrial function and possibly of the ubiquitin-proteasome system. As a consequence these compounds are receiving significant attention as therapeutic cytoprotective agents for the treatment of neurodegenerative and other diseases.

Authors+Show Affiliations

Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology and Rappaport Family Research Institute, Technion-Faculty of Medicine, Haifa 31096, Israel.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15223064

Citation

Mandel, Silvia, and Moussa B H. Youdim. "Catechin Polyphenols: Neurodegeneration and Neuroprotection in Neurodegenerative Diseases." Free Radical Biology & Medicine, vol. 37, no. 3, 2004, pp. 304-17.
Mandel S, Youdim MB. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radic Biol Med. 2004;37(3):304-17.
Mandel, S., & Youdim, M. B. (2004). Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radical Biology & Medicine, 37(3), 304-17.
Mandel S, Youdim MB. Catechin Polyphenols: Neurodegeneration and Neuroprotection in Neurodegenerative Diseases. Free Radic Biol Med. 2004 Aug 1;37(3):304-17. PubMed PMID: 15223064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. AU - Mandel,Silvia, AU - Youdim,Moussa B H, PY - 2004/03/01/received PY - 2004/04/05/revised PY - 2004/04/08/accepted PY - 2004/6/30/pubmed PY - 2005/2/17/medline PY - 2004/6/30/entrez SP - 304 EP - 17 JF - Free radical biology & medicine JO - Free Radic Biol Med VL - 37 IS - 3 N2 - Neurodegeneration in Parkinson's, Alzheimer's, and other neurodegenerative diseases seems to be multifactorial, in that a complex set of toxic reactions including inflammation, glutamatergic neurotoxicity, increases in iron and nitric oxide, depletion of endogenous antioxidants, reduced expression of trophic factors, dysfunction of the ubiquitin-proteasome system, and expression of proapoptotic proteins leads to the demise of neurons. Thus, the fundamental objective in neurodegeneration and neuroprotection research is to determine which of these factors constitutes the primary event, the sequence in which these events occur, and whether they act in concurrence in the pathogenic process. This has led to the current notion that drugs directed against a single target will be ineffective and rather a single drug or cocktail of drugs with pluripharmacological properties may be more suitable. Green tea catechin polyphenols, formerly thought to be simple radical scavengers, are now considered to invoke a spectrum of cellular mechanisms of action related to their neuroprotective activity. These include pharmacological activities like iron chelation, scavenging of radicals, activation of survival genes and cell signaling pathways, and regulation of mitochondrial function and possibly of the ubiquitin-proteasome system. As a consequence these compounds are receiving significant attention as therapeutic cytoprotective agents for the treatment of neurodegenerative and other diseases. SN - 0891-5849 UR - https://www.unboundmedicine.com/medline/citation/15223064/Catechin_polyphenols:_neurodegeneration_and_neuroprotection_in_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891584904003168 DB - PRIME DP - Unbound Medicine ER -