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On the course of the irritant reaction after irritation with sodium lauryl sulphate.
Skin Res Technol. 2004 Aug; 10(3):144-8.SR

Abstract

BACKGROUND

The sodium lauryl sulphate (SLS) irritation test is a well-established model for irritant contact dermatitis after the effects of surfactants.

AIM OF THE STUDY

The course of changes in corneometric measurements (stratum corneum hydration), in transepidermal water loss (TEWL), in laser Doppler measurements (epidermal perfusion) and in colorimetric measurements (skin redness), after a single SLS irritation, should be studied over time.

METHODS

Twenty healthy volunteers were studied. Irritation with 1% SLS solution was applied to the side of one forearm for 24 h under occlusive conditions, while the symmetrical experimental site remained untreated. Measurements were made for 9 days after completion of SLS irritation.

RESULTS

Stratum corneum hydration was reduced immediately after irritation, and subsequently a hyper-hydration was observed. The increase in TEWL, laser Doppler measurements and skin redness persisted for 7-9 days. With regard to skin redness, a mild blanching effect was noticeable after 9 days.

DISCUSSION

The evidence of very short-term exsiccation of the stratum corneum with persistent barrier damage, as well as reactive hyper-hydration and blanching of the skin, is remarkable. These first findings suggest that exsiccation of the stratum corneum is not caused by a damage to barrier lipids.

Authors+Show Affiliations

Department of Dermatology Municipal Hospital Karlsruhe GmbH, Germany. mgloor@onlinehome.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15225263

Citation

Gloor, Max, et al. "On the Course of the Irritant Reaction After Irritation With Sodium Lauryl Sulphate." Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), vol. 10, no. 3, 2004, pp. 144-8.
Gloor M, Senger B, Langenauer M, et al. On the course of the irritant reaction after irritation with sodium lauryl sulphate. Skin Res Technol. 2004;10(3):144-8.
Gloor, M., Senger, B., Langenauer, M., & Fluhr, J. W. (2004). On the course of the irritant reaction after irritation with sodium lauryl sulphate. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 10(3), 144-8.
Gloor M, et al. On the Course of the Irritant Reaction After Irritation With Sodium Lauryl Sulphate. Skin Res Technol. 2004;10(3):144-8. PubMed PMID: 15225263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - On the course of the irritant reaction after irritation with sodium lauryl sulphate. AU - Gloor,Max, AU - Senger,Bettina, AU - Langenauer,Marcel, AU - Fluhr,Joachim W, PY - 2004/7/1/pubmed PY - 2004/10/16/medline PY - 2004/7/1/entrez SP - 144 EP - 8 JF - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JO - Skin Res Technol VL - 10 IS - 3 N2 - BACKGROUND: The sodium lauryl sulphate (SLS) irritation test is a well-established model for irritant contact dermatitis after the effects of surfactants. AIM OF THE STUDY: The course of changes in corneometric measurements (stratum corneum hydration), in transepidermal water loss (TEWL), in laser Doppler measurements (epidermal perfusion) and in colorimetric measurements (skin redness), after a single SLS irritation, should be studied over time. METHODS: Twenty healthy volunteers were studied. Irritation with 1% SLS solution was applied to the side of one forearm for 24 h under occlusive conditions, while the symmetrical experimental site remained untreated. Measurements were made for 9 days after completion of SLS irritation. RESULTS: Stratum corneum hydration was reduced immediately after irritation, and subsequently a hyper-hydration was observed. The increase in TEWL, laser Doppler measurements and skin redness persisted for 7-9 days. With regard to skin redness, a mild blanching effect was noticeable after 9 days. DISCUSSION: The evidence of very short-term exsiccation of the stratum corneum with persistent barrier damage, as well as reactive hyper-hydration and blanching of the skin, is remarkable. These first findings suggest that exsiccation of the stratum corneum is not caused by a damage to barrier lipids. SN - 0909-752X UR - https://www.unboundmedicine.com/medline/citation/15225263/On_the_course_of_the_irritant_reaction_after_irritation_with_sodium_lauryl_sulphate_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0909-752X&date=2004&volume=10&issue=3&spage=144 DB - PRIME DP - Unbound Medicine ER -