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Clinically normal atopic skin vs. non-atopic skin as seen through electrical impedance.
Skin Res Technol. 2004 Aug; 10(3):178-83.SR

Abstract

BACKGROUND/AIMS

In an earlier study, we have shown that the electrical impedance (IMP) is dependent on the lipid content of the stratum corneum as studied by lipid extraction. Therefore, we now employ the IMP technique to compare the properties of clinically normal atopic skin with that of non-atopic skin. We looked at the same time at concomitant alterations in transepidermal water loss (TEWL) and skin moisture results.

METHODS

Twenty-two healthy participants and 26 patients with atopic dermatitis were recruited. One test site on each volar forearm was used in the test procedure, of cyclohexane swabbing, skin stripping, and lipid extraction using a mixture of hexane:isopropanol. Responses were evaluated by measuring TEWL, skin moisture using electrical capacitance, and finally IMP spectroscopy in the frequency range 1 kHz to 1 MHz before the start of the study, after each step of the test procedure, and also during a 2 weeks recovery period.

RESULTS

Only the IMP results showed significant changes between baseline values of clinically normal atopic skin and healthy skin. Furthermore, IMP and TEWL showed significantly larger reactivity for the atopic group after the skin stripping procedure, and IMP after lipid extraction as well.

CONCLUSION

Our results show that IMP is a useful method for detection of changes in the lipid content of the stratum corneum by discriminating healthy looking atopic skin from healthy control skin, and to detect changes in reactivity between the two groups.

Authors+Show Affiliations

Department of Dermatology I 43, Huddinge University Hospital, Huddinge, Sweden. ingrid.nicander@cob.ki.seNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15225268

Citation

Nicander, Ingrid, and Stig Ollmar. "Clinically Normal Atopic Skin Vs. Non-atopic Skin as Seen Through Electrical Impedance." Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), vol. 10, no. 3, 2004, pp. 178-83.
Nicander I, Ollmar S. Clinically normal atopic skin vs. non-atopic skin as seen through electrical impedance. Skin Res Technol. 2004;10(3):178-83.
Nicander, I., & Ollmar, S. (2004). Clinically normal atopic skin vs. non-atopic skin as seen through electrical impedance. Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 10(3), 178-83.
Nicander I, Ollmar S. Clinically Normal Atopic Skin Vs. Non-atopic Skin as Seen Through Electrical Impedance. Skin Res Technol. 2004;10(3):178-83. PubMed PMID: 15225268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinically normal atopic skin vs. non-atopic skin as seen through electrical impedance. AU - Nicander,Ingrid, AU - Ollmar,Stig, PY - 2004/7/1/pubmed PY - 2004/10/16/medline PY - 2004/7/1/entrez SP - 178 EP - 83 JF - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JO - Skin Res Technol VL - 10 IS - 3 N2 - BACKGROUND/AIMS: In an earlier study, we have shown that the electrical impedance (IMP) is dependent on the lipid content of the stratum corneum as studied by lipid extraction. Therefore, we now employ the IMP technique to compare the properties of clinically normal atopic skin with that of non-atopic skin. We looked at the same time at concomitant alterations in transepidermal water loss (TEWL) and skin moisture results. METHODS: Twenty-two healthy participants and 26 patients with atopic dermatitis were recruited. One test site on each volar forearm was used in the test procedure, of cyclohexane swabbing, skin stripping, and lipid extraction using a mixture of hexane:isopropanol. Responses were evaluated by measuring TEWL, skin moisture using electrical capacitance, and finally IMP spectroscopy in the frequency range 1 kHz to 1 MHz before the start of the study, after each step of the test procedure, and also during a 2 weeks recovery period. RESULTS: Only the IMP results showed significant changes between baseline values of clinically normal atopic skin and healthy skin. Furthermore, IMP and TEWL showed significantly larger reactivity for the atopic group after the skin stripping procedure, and IMP after lipid extraction as well. CONCLUSION: Our results show that IMP is a useful method for detection of changes in the lipid content of the stratum corneum by discriminating healthy looking atopic skin from healthy control skin, and to detect changes in reactivity between the two groups. SN - 0909-752X UR - https://www.unboundmedicine.com/medline/citation/15225268/Clinically_normal_atopic_skin_vs__non_atopic_skin_as_seen_through_electrical_impedance_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0909-752X&date=2004&volume=10&issue=3&spage=178 DB - PRIME DP - Unbound Medicine ER -