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Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of bromisovalum.
J Anal Toxicol. 1992 May-Jun; 16(3):163-5.JA

Abstract

A simple and rapid method for isolation of bromisovalum with Sep-Pak C18 cartridges from human whole blood, plasma, and urine containing allylisopropylacetylurea as an internal standard, is presented. Detection of the drugs was made by nonpolar wide-bore capillary gas chromatography (GC) with flame ionization. The drug-containing samples, after mixing with water, were directly applied to the cartridges and eluted with chloroform-methanol (9:1). The recoveries of bromisovalum with use of the cartridges were excellent. Bromisovalum and internal standard allylisopropylacetylurea could be satisfactorily separated from each other and from impurities with the wide-bore capillary column. The detection limit for bromisovalum was 2-5 ng in an injected volume.

Authors+Show Affiliations

Department of Legal Medicine, Hamamatsu University School of Medicine, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1522708

Citation

Kumazawa, T, et al. "Rapid Isolation With Sep-Pak C18 Cartridges and Wide-bore Capillary Gas Chromatography of Bromisovalum." Journal of Analytical Toxicology, vol. 16, no. 3, 1992, pp. 163-5.
Kumazawa T, Seno H, Suzuki O. Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of bromisovalum. J Anal Toxicol. 1992;16(3):163-5.
Kumazawa, T., Seno, H., & Suzuki, O. (1992). Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of bromisovalum. Journal of Analytical Toxicology, 16(3), 163-5.
Kumazawa T, Seno H, Suzuki O. Rapid Isolation With Sep-Pak C18 Cartridges and Wide-bore Capillary Gas Chromatography of Bromisovalum. J Anal Toxicol. 1992 May-Jun;16(3):163-5. PubMed PMID: 1522708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of bromisovalum. AU - Kumazawa,T, AU - Seno,H, AU - Suzuki,O, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 163 EP - 5 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 16 IS - 3 N2 - A simple and rapid method for isolation of bromisovalum with Sep-Pak C18 cartridges from human whole blood, plasma, and urine containing allylisopropylacetylurea as an internal standard, is presented. Detection of the drugs was made by nonpolar wide-bore capillary gas chromatography (GC) with flame ionization. The drug-containing samples, after mixing with water, were directly applied to the cartridges and eluted with chloroform-methanol (9:1). The recoveries of bromisovalum with use of the cartridges were excellent. Bromisovalum and internal standard allylisopropylacetylurea could be satisfactorily separated from each other and from impurities with the wide-bore capillary column. The detection limit for bromisovalum was 2-5 ng in an injected volume. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/1522708/Rapid_isolation_with_Sep_Pak_C18_cartridges_and_wide_bore_capillary_gas_chromatography_of_bromisovalum_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/16.3.163 DB - PRIME DP - Unbound Medicine ER -
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