Tags

Type your tag names separated by a space and hit enter

Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study.
Am J Psychiatry. 2004 Jul; 161(7):1219-23.AJ

Abstract

OBJECTIVE

The prevalence of cigarette smoking among schizophrenia patients is significantly higher than in the general population; this may reflect self-medication of symptoms and/or adverse effects of neuroleptics. The authors examined the prevalence of cigarette smoking in apparently healthy adolescents later hospitalized for schizophrenia.

METHOD

Each year, a random sample of male Israeli military recruits, who have been screened and found not to be suffering from major psychopathology, complete a smoking questionnaire. Through the Israeli National Psychiatric Hospitalization Case Registry, 14,248 of these adolescents were followed to determine later psychiatric hospitalization.

RESULTS

Of the 14,248 adolescents assessed, 4,052 (28.4%) reported smoking at least one cigarette a day. Over a 4-16-year follow-up, the prevalence of schizophrenia in the entire cohort was 0.3% (N=44). Smokers were at greater risk for later schizophrenia; the adjusted relative risk was 1.94, and the 95% confidence interval (CI) was 1.05-3.58. The number of cigarettes smoked was significantly associated with the risk for schizophrenia. Compared to nonsmokers, adolescents who smoked 1-9 cigarettes/day were 1.38 times (95% CI=0.48-4.00) as likely to be hospitalized later for schizophrenia, and adolescents who smoked 10 cigarettes/day or more were 2.28 times (95% CI=1.19-4.34) as likely; the latter difference was statistically significant.

CONCLUSIONS

Taken together with the existing data on abnormalities in nicotinic transmission in patients and their relatives, this higher prevalence of smoking in future schizophrenia patients, before the onset of their illness, might indicate that impaired nicotinic neurotransmission is involved in the pathophysiology of schizophrenia.

Authors+Show Affiliations

Department of Psychiatry, Sheba Medical Center, Tel Hashomer 52621, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15229054

Citation

Weiser, Mark, et al. "Higher Rates of Cigarette Smoking in Male Adolescents Before the Onset of Schizophrenia: a Historical-prospective Cohort Study." The American Journal of Psychiatry, vol. 161, no. 7, 2004, pp. 1219-23.
Weiser M, Reichenberg A, Grotto I, et al. Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. Am J Psychiatry. 2004;161(7):1219-23.
Weiser, M., Reichenberg, A., Grotto, I., Yasvitzky, R., Rabinowitz, J., Lubin, G., Nahon, D., Knobler, H. Y., & Davidson, M. (2004). Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. The American Journal of Psychiatry, 161(7), 1219-23.
Weiser M, et al. Higher Rates of Cigarette Smoking in Male Adolescents Before the Onset of Schizophrenia: a Historical-prospective Cohort Study. Am J Psychiatry. 2004;161(7):1219-23. PubMed PMID: 15229054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. AU - Weiser,Mark, AU - Reichenberg,Abraham, AU - Grotto,Itamar, AU - Yasvitzky,Ross, AU - Rabinowitz,Jonathan, AU - Lubin,Gad, AU - Nahon,Daniella, AU - Knobler,Haim Y, AU - Davidson,Michael, PY - 2004/7/2/pubmed PY - 2004/8/20/medline PY - 2004/7/2/entrez SP - 1219 EP - 23 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 161 IS - 7 N2 - OBJECTIVE: The prevalence of cigarette smoking among schizophrenia patients is significantly higher than in the general population; this may reflect self-medication of symptoms and/or adverse effects of neuroleptics. The authors examined the prevalence of cigarette smoking in apparently healthy adolescents later hospitalized for schizophrenia. METHOD: Each year, a random sample of male Israeli military recruits, who have been screened and found not to be suffering from major psychopathology, complete a smoking questionnaire. Through the Israeli National Psychiatric Hospitalization Case Registry, 14,248 of these adolescents were followed to determine later psychiatric hospitalization. RESULTS: Of the 14,248 adolescents assessed, 4,052 (28.4%) reported smoking at least one cigarette a day. Over a 4-16-year follow-up, the prevalence of schizophrenia in the entire cohort was 0.3% (N=44). Smokers were at greater risk for later schizophrenia; the adjusted relative risk was 1.94, and the 95% confidence interval (CI) was 1.05-3.58. The number of cigarettes smoked was significantly associated with the risk for schizophrenia. Compared to nonsmokers, adolescents who smoked 1-9 cigarettes/day were 1.38 times (95% CI=0.48-4.00) as likely to be hospitalized later for schizophrenia, and adolescents who smoked 10 cigarettes/day or more were 2.28 times (95% CI=1.19-4.34) as likely; the latter difference was statistically significant. CONCLUSIONS: Taken together with the existing data on abnormalities in nicotinic transmission in patients and their relatives, this higher prevalence of smoking in future schizophrenia patients, before the onset of their illness, might indicate that impaired nicotinic neurotransmission is involved in the pathophysiology of schizophrenia. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/15229054/Higher_rates_of_cigarette_smoking_in_male_adolescents_before_the_onset_of_schizophrenia:_a_historical_prospective_cohort_study_ L2 - https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.161.7.1219?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -