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Dietary protein and the risk of cholecystectomy in a cohort of US women: the Nurses' Health Study.

Abstract

In animals, vegetable protein can inhibit gallstone formation. Epidemiologic studies of dietary protein in relation to gallstone disease are sparse, and the effects of dietary protein of different origins are not clear. The authors aimed to examine the relation between dietary protein intake and risk of cholecystectomy among participants in the Nurses' Health Study, a cohort study of US women in 11 states. During 20 years of follow-up (1980-2000), the authors documented 7,831 cases of cholecystectomy. After adjustment for age, other known or suspected risk factors, and specific fats in a multivariate model, the relative risk of cholecystectomy for women in the highest quintile of dietary total protein intake compared with women in the lowest quintile was 1.00 (95% confidence interval (CI): 0.93, 1.08; p for trend = 0.46). When extreme quintiles were compared, the relative risk for animal protein intake was 1.07 (95% CI: 0.98, 1.15; p for trend = 0.08), whereas the relative risk for vegetable protein intake was 0.79 (95% CI: 0.71, 0.88; p for trend < 0.0001), with a significant dose-response relation. Additional mutual adjustment between animal and vegetable proteins did not materially alter the risks. These results suggest that increased consumption of vegetable protein in the context of an energy-balanced diet can reduce the risk of cholecystectomy in women.

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  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. hpcjt@channing.harvard.edu

    , ,

    Source

    American journal of epidemiology 160:1 2004 Jul 01 pg 11-8

    MeSH

    Adult
    Animals
    Cholecystectomy
    Cohort Studies
    Confidence Intervals
    Diet Surveys
    Dietary Proteins
    Female
    Gallstones
    Humans
    Life Style
    Middle Aged
    Nurses
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15229112

    Citation

    Tsai, Chung-Jyi, et al. "Dietary Protein and the Risk of Cholecystectomy in a Cohort of US Women: the Nurses' Health Study." American Journal of Epidemiology, vol. 160, no. 1, 2004, pp. 11-8.
    Tsai CJ, Leitzmann MF, Willett WC, et al. Dietary protein and the risk of cholecystectomy in a cohort of US women: the Nurses' Health Study. Am J Epidemiol. 2004;160(1):11-8.
    Tsai, C. J., Leitzmann, M. F., Willett, W. C., & Giovannucci, E. L. (2004). Dietary protein and the risk of cholecystectomy in a cohort of US women: the Nurses' Health Study. American Journal of Epidemiology, 160(1), pp. 11-8.
    Tsai CJ, et al. Dietary Protein and the Risk of Cholecystectomy in a Cohort of US Women: the Nurses' Health Study. Am J Epidemiol. 2004 Jul 1;160(1):11-8. PubMed PMID: 15229112.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary protein and the risk of cholecystectomy in a cohort of US women: the Nurses' Health Study. AU - Tsai,Chung-Jyi, AU - Leitzmann,Michael F, AU - Willett,Walter C, AU - Giovannucci,Edward L, PY - 2004/7/2/pubmed PY - 2004/8/4/medline PY - 2004/7/2/entrez SP - 11 EP - 8 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 160 IS - 1 N2 - In animals, vegetable protein can inhibit gallstone formation. Epidemiologic studies of dietary protein in relation to gallstone disease are sparse, and the effects of dietary protein of different origins are not clear. The authors aimed to examine the relation between dietary protein intake and risk of cholecystectomy among participants in the Nurses' Health Study, a cohort study of US women in 11 states. During 20 years of follow-up (1980-2000), the authors documented 7,831 cases of cholecystectomy. After adjustment for age, other known or suspected risk factors, and specific fats in a multivariate model, the relative risk of cholecystectomy for women in the highest quintile of dietary total protein intake compared with women in the lowest quintile was 1.00 (95% confidence interval (CI): 0.93, 1.08; p for trend = 0.46). When extreme quintiles were compared, the relative risk for animal protein intake was 1.07 (95% CI: 0.98, 1.15; p for trend = 0.08), whereas the relative risk for vegetable protein intake was 0.79 (95% CI: 0.71, 0.88; p for trend < 0.0001), with a significant dose-response relation. Additional mutual adjustment between animal and vegetable proteins did not materially alter the risks. These results suggest that increased consumption of vegetable protein in the context of an energy-balanced diet can reduce the risk of cholecystectomy in women. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15229112/Dietary_protein_and_the_risk_of_cholecystectomy_in_a_cohort_of_US_women:_the_Nurses'_Health_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwh170 DB - PRIME DP - Unbound Medicine ER -