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Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature.
Can J Gastroenterol. 2004 Jul; 18(7):459-62.CJ

Abstract

A 56-year-old woman was noted to have a 5 cm to 6 cm long, irregular narrowing of the distal esophagus on an upper gastrointestinal series. Initial endoscopy revealed a polypoid mass in the distal esophagus and concurrent endoscopic ultrasound revealed changes typical of inflammation but no evidence of an obvious neoplastic process. Repeated biopsies revealed only inflammation with no evidence of malignancy. Only after prolonged acid suppression did biopsies reveal verrucous carcinoma of the esophagus. The patient underwent a trans-hiatal esophagectomy and has remained well with no evidence of progression since. Verrucous carcinoma is a rare variant of squamous cell carcinoma, taking on a papillary or warty appearance grossly. Histological diagnosis may be difficult because this tumour typically shows no high-grade dysplasia. Therefore, diagnosis can be challenging, often requiring multiple sets of endoscopic biopsies due to the overlying hyperkeratotic layer. Of the 20 cases that have been reported, this is the second to provide an endosonographic description and the first to describe a change in endoscopic appearance with acid suppression.

Authors+Show Affiliations

Division of Gastroenterology, University of Calary, Calgary, Alberta, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15229749

Citation

Devlin, Shane, et al. "Verrucous Carcinoma of the Esophagus Eluding Multiple Sets of Endoscopic Biopsies and Endoscopic Ultrasound: a Case Report and Review of the Literature." Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie, vol. 18, no. 7, 2004, pp. 459-62.
Devlin S, Falck V, Urbanski SJ, et al. Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. Can J Gastroenterol. 2004;18(7):459-62.
Devlin, S., Falck, V., Urbanski, S. J., Mitchell, P., & Romagnuolo, J. (2004). Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie, 18(7), 459-62.
Devlin S, et al. Verrucous Carcinoma of the Esophagus Eluding Multiple Sets of Endoscopic Biopsies and Endoscopic Ultrasound: a Case Report and Review of the Literature. Can J Gastroenterol. 2004;18(7):459-62. PubMed PMID: 15229749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literature. AU - Devlin,Shane, AU - Falck,Vincent, AU - Urbanski,Stefan J, AU - Mitchell,Philip, AU - Romagnuolo,Joseph, PY - 2004/7/2/pubmed PY - 2004/10/27/medline PY - 2004/7/2/entrez SP - 459 EP - 62 JF - Canadian journal of gastroenterology = Journal canadien de gastroenterologie JO - Can. J. Gastroenterol. VL - 18 IS - 7 N2 - A 56-year-old woman was noted to have a 5 cm to 6 cm long, irregular narrowing of the distal esophagus on an upper gastrointestinal series. Initial endoscopy revealed a polypoid mass in the distal esophagus and concurrent endoscopic ultrasound revealed changes typical of inflammation but no evidence of an obvious neoplastic process. Repeated biopsies revealed only inflammation with no evidence of malignancy. Only after prolonged acid suppression did biopsies reveal verrucous carcinoma of the esophagus. The patient underwent a trans-hiatal esophagectomy and has remained well with no evidence of progression since. Verrucous carcinoma is a rare variant of squamous cell carcinoma, taking on a papillary or warty appearance grossly. Histological diagnosis may be difficult because this tumour typically shows no high-grade dysplasia. Therefore, diagnosis can be challenging, often requiring multiple sets of endoscopic biopsies due to the overlying hyperkeratotic layer. Of the 20 cases that have been reported, this is the second to provide an endosonographic description and the first to describe a change in endoscopic appearance with acid suppression. SN - 0835-7900 UR - https://www.unboundmedicine.com/medline/citation/15229749/Verrucous_carcinoma_of_the_esophagus_eluding_multiple_sets_of_endoscopic_biopsies_and_endoscopic_ultrasound:_a_case_report_and_review_of_the_literature_ L2 - https://medlineplus.gov/esophagealcancer.html DB - PRIME DP - Unbound Medicine ER -