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Chemical analysis and antimicrobial activity of Greek propolis.
Planta Med. 2004 Jun; 70(6):515-9.PM

Abstract

One new 2,3-dihydroflavone derivative, 7- O-prenylstrobopinin, and 25 known diterpenes and phenolic compounds were identified from the n-butanol extract of Greek propolis. This is the first time that diterpenes have been isolated from propolis of European origin, while six of the known compounds are reported as propolis constituents for the first time. The structures of the isolated compounds were determined by spectroscopic methods, mainly by the concerted application of 1D, 2D NMR techniques (HMQC, HMBC, NOESY) and mass spectrometry. The studied sample and the isolated compounds were tested for their antimicrobial activity against Gram (+/-) bacteria and fungi and five of them exhibited strong activities.

Authors+Show Affiliations

Melliou E
Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, University of Athens, 157-71 Athens, Greece.
Chinou I
No affiliation info available

MeSH

Anti-Infective AgentsDiterpenesGram-Negative BacteriaGram-Positive BacteriaGreeceHumansMedicine, TraditionalMicrobial Sensitivity TestsMitosporic FungiPhytotherapyPlant ExtractsPropolis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15229802

Citation

Melliou, Eleni, and Ioanna Chinou. "Chemical Analysis and Antimicrobial Activity of Greek Propolis." Planta Medica, vol. 70, no. 6, 2004, pp. 515-9.
Melliou E, Chinou I. Chemical analysis and antimicrobial activity of Greek propolis. Planta Med. 2004;70(6):515-9.
Melliou, E., & Chinou, I. (2004). Chemical analysis and antimicrobial activity of Greek propolis. Planta Medica, 70(6), 515-9.
Melliou E, Chinou I. Chemical Analysis and Antimicrobial Activity of Greek Propolis. Planta Med. 2004;70(6):515-9. PubMed PMID: 15229802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical analysis and antimicrobial activity of Greek propolis. AU - Melliou,Eleni, AU - Chinou,Ioanna, PY - 2004/7/2/pubmed PY - 2004/8/28/medline PY - 2004/7/2/entrez SP - 515 EP - 9 JF - Planta medica JO - Planta Med VL - 70 IS - 6 N2 - One new 2,3-dihydroflavone derivative, 7- O-prenylstrobopinin, and 25 known diterpenes and phenolic compounds were identified from the n-butanol extract of Greek propolis. This is the first time that diterpenes have been isolated from propolis of European origin, while six of the known compounds are reported as propolis constituents for the first time. The structures of the isolated compounds were determined by spectroscopic methods, mainly by the concerted application of 1D, 2D NMR techniques (HMQC, HMBC, NOESY) and mass spectrometry. The studied sample and the isolated compounds were tested for their antimicrobial activity against Gram (+/-) bacteria and fungi and five of them exhibited strong activities. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/15229802/Chemical_analysis_and_antimicrobial_activity_of_Greek_propolis_ DB - PRIME DP - Unbound Medicine ER -