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[Serum tumor necrosis factor alpha (TNF-alpha) concentration correlates with soluble adhesion molecules and vascular endothelial growth factor (VEGF) in rheumatoid arthritis].
Przegl Lek. 2004; 61(2):86-9.PL

Abstract

In present study we investigated whether the serum concentration of tumour necrosis factor alpha (TNF-alpha) is associated with soluble adhesion molecules and vascular endothelial growth factor (VEGF) in rheumatoid arthritis (RA) patients. Serum levels of TNF-alpha, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble E-selectin (sE-selectin) and VEGF were assessed by ELISA in 38 patients with RA. We demonstrated the TNF-alpha to correlate with sICAM-1 (p < 0.001), sVCAM-1 (p < 0.01) and VEGF (p < 0.01). No association was noticed between TNF-alpha and sE-selectin serum concentrations. Moreover, serum TNF-alpha, sICAM-1, sVCAM-1 and VEGF levels correlated with markers of RA activity such as the erythrocyte sedimentation rate, C reactive protein level and the number of swollen joints. Data presented in this report support the concept of the VEGF synthesis stimulation by TNF-alpha. Analysis of the serum TNF-alpha, sICAM-1, sVCAM-1 and VEGF levels may be useful in the prediction of the RA activity.

Authors+Show Affiliations

Klinika Reumatologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku. klimp@amb.edu.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

15230147

Citation

Klimiuk, Piotr Adrian, et al. "[Serum Tumor Necrosis Factor Alpha (TNF-alpha) Concentration Correlates With Soluble Adhesion Molecules and Vascular Endothelial Growth Factor (VEGF) in Rheumatoid Arthritis]." Przeglad Lekarski, vol. 61, no. 2, 2004, pp. 86-9.
Klimiuk PA, Sierakowski S, Fiedorczyk M, et al. [Serum tumor necrosis factor alpha (TNF-alpha) concentration correlates with soluble adhesion molecules and vascular endothelial growth factor (VEGF) in rheumatoid arthritis]. Przegl Lek. 2004;61(2):86-9.
Klimiuk, P. A., Sierakowski, S., Fiedorczyk, M., & Chwiećko, J. (2004). [Serum tumor necrosis factor alpha (TNF-alpha) concentration correlates with soluble adhesion molecules and vascular endothelial growth factor (VEGF) in rheumatoid arthritis]. Przeglad Lekarski, 61(2), 86-9.
Klimiuk PA, et al. [Serum Tumor Necrosis Factor Alpha (TNF-alpha) Concentration Correlates With Soluble Adhesion Molecules and Vascular Endothelial Growth Factor (VEGF) in Rheumatoid Arthritis]. Przegl Lek. 2004;61(2):86-9. PubMed PMID: 15230147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum tumor necrosis factor alpha (TNF-alpha) concentration correlates with soluble adhesion molecules and vascular endothelial growth factor (VEGF) in rheumatoid arthritis]. AU - Klimiuk,Piotr Adrian, AU - Sierakowski,Stanisław, AU - Fiedorczyk,Małgorzata, AU - Chwiećko,Justyna, PY - 2004/7/3/pubmed PY - 2004/8/26/medline PY - 2004/7/3/entrez SP - 86 EP - 9 JF - Przeglad lekarski JO - Przegl Lek VL - 61 IS - 2 N2 - In present study we investigated whether the serum concentration of tumour necrosis factor alpha (TNF-alpha) is associated with soluble adhesion molecules and vascular endothelial growth factor (VEGF) in rheumatoid arthritis (RA) patients. Serum levels of TNF-alpha, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), soluble E-selectin (sE-selectin) and VEGF were assessed by ELISA in 38 patients with RA. We demonstrated the TNF-alpha to correlate with sICAM-1 (p < 0.001), sVCAM-1 (p < 0.01) and VEGF (p < 0.01). No association was noticed between TNF-alpha and sE-selectin serum concentrations. Moreover, serum TNF-alpha, sICAM-1, sVCAM-1 and VEGF levels correlated with markers of RA activity such as the erythrocyte sedimentation rate, C reactive protein level and the number of swollen joints. Data presented in this report support the concept of the VEGF synthesis stimulation by TNF-alpha. Analysis of the serum TNF-alpha, sICAM-1, sVCAM-1 and VEGF levels may be useful in the prediction of the RA activity. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/15230147/[Serum_tumor_necrosis_factor_alpha__TNF_alpha__concentration_correlates_with_soluble_adhesion_molecules_and_vascular_endothelial_growth_factor__VEGF__in_rheumatoid_arthritis]_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -