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Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma.
Int J Dermatol. 2004 Jul; 43(7):530-2.IJ

Abstract

Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trélat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.

Authors+Show Affiliations

Pentenero M
Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, and Surgical Pathology Section, University of Turin, Turin, Italy.
Carrozzo M
No affiliation info available
Pagano M
No affiliation info available
Gandolfo S
No affiliation info available

MeSH

Acanthosis NigricansAdenocarcinomaAntineoplastic AgentsFatal OutcomeGastrectomyHumansKeratosis, SeborrheicMaleMiddle AgedMouth DiseasesParaneoplastic SyndromesStomach Neoplasms

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15230897

Citation

Pentenero, M, et al. "Oral Acanthosis Nigricans, Tripe Palms and Sign of Leser-trélat in a Patient With Gastric Adenocarcinoma." International Journal of Dermatology, vol. 43, no. 7, 2004, pp. 530-2.
Pentenero M, Carrozzo M, Pagano M, et al. Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma. Int J Dermatol. 2004;43(7):530-2.
Pentenero, M., Carrozzo, M., Pagano, M., & Gandolfo, S. (2004). Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma. International Journal of Dermatology, 43(7), 530-2.
Pentenero M, et al. Oral Acanthosis Nigricans, Tripe Palms and Sign of Leser-trélat in a Patient With Gastric Adenocarcinoma. Int J Dermatol. 2004;43(7):530-2. PubMed PMID: 15230897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma. AU - Pentenero,M, AU - Carrozzo,M, AU - Pagano,M, AU - Gandolfo,S, PY - 2004/7/3/pubmed PY - 2004/10/16/medline PY - 2004/7/3/entrez SP - 530 EP - 2 JF - International journal of dermatology JO - Int J Dermatol VL - 43 IS - 7 N2 - Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trélat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/15230897/Oral_acanthosis_nigricans_tripe_palms_and_sign_of_leser_trélat_in_a_patient_with_gastric_adenocarcinoma_ DB - PRIME DP - Unbound Medicine ER -