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Predictive value of low BMD for 1-year fracture outcomes is similar for postmenopausal women ages 50-64 and 65 and Older: results from the National Osteoporosis Risk Assessment (NORA).
J Bone Miner Res 2004; 19(8):1215-20JB

Abstract

The relationship of low bone mass and fracture in younger postmenopausal women has not been extensively studied. In a large cohort of postmenopausal women > or =50 years of age, we found the relationship of BMD measured at peripheral sites and subsequent 1-year fracture risk to be similar between women <65 and those > or =65 years of age.

INTRODUCTION

Low bone mass and fractures are prevalent in older postmenopausal women. However, the frequency of low bone mass and fracture in younger postmenopausal women has not been studied extensively. There are very limited data regarding the association between BMD measurements and fractures in postmenopausal women who are between the ages of 50 and 64.

MATERIALS AND METHODS

In the National Osteoporosis Risk Assessment (NORA) we studied the frequency of low bone mass and its association with fracture in women 50-64 years of age in comparison with women > or =65 of age. NORA enrolled 200,160 postmenopausal women > or =50 years of age who had no prior diagnosis of osteoporosis. Baseline BMD was measured at the heel, forearm, or finger. A 1-year follow-up survey requesting incident fractures since baseline was completed by 163,935 women, 87,594 (53%) of whom were 50-64 years of age. The association between BMD and fracture was assessed using logistic regression, adjusted for important covariates.

RESULTS

Thirty-one percent of women 50-64 years of age had low bone mass (T scores < or = -1.0) compared to 62% of women > or =65 years of age. During the first year of follow-up, 2440 women reported fractures of wrist/forearm, rib, spine, or hip, including 440 hip fractures. Nine hundred four women 50-64 years of age reported fractures, including 86 hip fractures, accounting for 37% of fractures and 20% of hip fractures reported in the entire NORA cohort. Relative risk for osteoporotic fracture was 1.5 for each SD decrease in BMD for both the younger and older groups of women.

CONCLUSION

Low BMD in younger postmenopausal women 50-64 years of age showed a 1-year relative risk of fracture similar to that found in women > or =65 years of age.

Authors+Show Affiliations

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032-3784, USA. es27@columbia.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15231007

Citation

Siris, Ethel S., et al. "Predictive Value of Low BMD for 1-year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50-64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA)." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 19, no. 8, 2004, pp. 1215-20.
Siris ES, Brenneman SK, Miller PD, et al. Predictive value of low BMD for 1-year fracture outcomes is similar for postmenopausal women ages 50-64 and 65 and Older: results from the National Osteoporosis Risk Assessment (NORA). J Bone Miner Res. 2004;19(8):1215-20.
Siris, E. S., Brenneman, S. K., Miller, P. D., Barrett-Connor, E., Chen, Y. T., Sherwood, L. M., & Abbott, T. A. (2004). Predictive value of low BMD for 1-year fracture outcomes is similar for postmenopausal women ages 50-64 and 65 and Older: results from the National Osteoporosis Risk Assessment (NORA). Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 19(8), pp. 1215-20.
Siris ES, et al. Predictive Value of Low BMD for 1-year Fracture Outcomes Is Similar for Postmenopausal Women Ages 50-64 and 65 and Older: Results From the National Osteoporosis Risk Assessment (NORA). J Bone Miner Res. 2004;19(8):1215-20. PubMed PMID: 15231007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive value of low BMD for 1-year fracture outcomes is similar for postmenopausal women ages 50-64 and 65 and Older: results from the National Osteoporosis Risk Assessment (NORA). AU - Siris,Ethel S, AU - Brenneman,Susan K, AU - Miller,Paul D, AU - Barrett-Connor,Elizabeth, AU - Chen,Ya-Ting, AU - Sherwood,Louis M, AU - Abbott,Thomas A, Y1 - 2004/05/10/ PY - 2003/12/04/received PY - 2004/03/03/revised PY - 2004/04/30/accepted PY - 2004/7/3/pubmed PY - 2005/3/17/medline PY - 2004/7/3/entrez SP - 1215 EP - 20 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 19 IS - 8 N2 - UNLABELLED: The relationship of low bone mass and fracture in younger postmenopausal women has not been extensively studied. In a large cohort of postmenopausal women > or =50 years of age, we found the relationship of BMD measured at peripheral sites and subsequent 1-year fracture risk to be similar between women <65 and those > or =65 years of age. INTRODUCTION: Low bone mass and fractures are prevalent in older postmenopausal women. However, the frequency of low bone mass and fracture in younger postmenopausal women has not been studied extensively. There are very limited data regarding the association between BMD measurements and fractures in postmenopausal women who are between the ages of 50 and 64. MATERIALS AND METHODS: In the National Osteoporosis Risk Assessment (NORA) we studied the frequency of low bone mass and its association with fracture in women 50-64 years of age in comparison with women > or =65 of age. NORA enrolled 200,160 postmenopausal women > or =50 years of age who had no prior diagnosis of osteoporosis. Baseline BMD was measured at the heel, forearm, or finger. A 1-year follow-up survey requesting incident fractures since baseline was completed by 163,935 women, 87,594 (53%) of whom were 50-64 years of age. The association between BMD and fracture was assessed using logistic regression, adjusted for important covariates. RESULTS: Thirty-one percent of women 50-64 years of age had low bone mass (T scores < or = -1.0) compared to 62% of women > or =65 years of age. During the first year of follow-up, 2440 women reported fractures of wrist/forearm, rib, spine, or hip, including 440 hip fractures. Nine hundred four women 50-64 years of age reported fractures, including 86 hip fractures, accounting for 37% of fractures and 20% of hip fractures reported in the entire NORA cohort. Relative risk for osteoporotic fracture was 1.5 for each SD decrease in BMD for both the younger and older groups of women. CONCLUSION: Low BMD in younger postmenopausal women 50-64 years of age showed a 1-year relative risk of fracture similar to that found in women > or =65 years of age. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/15231007/Predictive_value_of_low_BMD_for_1_year_fracture_outcomes_is_similar_for_postmenopausal_women_ages_50_64_and_65_and_Older:_results_from_the_National_Osteoporosis_Risk_Assessment__NORA__ L2 - https://doi.org/10.1359/JBMR.040508 DB - PRIME DP - Unbound Medicine ER -