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[Study on the risk factors and its interaction on Parkinson disease].
Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Jun; 25(6):527-30.ZL

Abstract

OBJECTIVE

To explore the risk factors of Parkinson disease (PD), interaction between family history of PD and other risk factors, as well as the relative strength of genetic factors over the vulnerability of PD.

METHODS

One 1:1 matched case-control study including 157 pairs of cases and controls was conducted in Qilu Hospital of Shandong University.

RESULTS

Conditional logistic regression analysis showed that family history of PD, mental labor, insecticide, alcohol drinking and history of depression all had positive relationship, while smoking had a negative relationship with PD. The AP (AB)s of family history of PD and insecticide, alcohol drinking, history of depression were 55.2%, 34.0%, 41.4% and the RERIs were 8.96, 3.31, 7.85 respectively. The heritability of PD patients' first degree relatives was 36.86% +/- 5.76%, and second degree relatives was 20.66% +/- 6.81%.

CONCLUSION

Family history of PD had an additive model synergism on PD, coexisting with other risk factors. Genetic factors had a smaller action on PD than environmental factors.

Authors+Show Affiliations

Shandong Sport Research Center, Jinan 250002, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15231138

Citation

Tan, Xian-Hua, et al. "[Study On the Risk Factors and Its Interaction On Parkinson Disease]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 25, no. 6, 2004, pp. 527-30.
Tan XH, Wang SM, Xue NQ, et al. [Study on the risk factors and its interaction on Parkinson disease]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25(6):527-30.
Tan, X. H., Wang, S. M., Xue, N. Q., Teng, W. T., & Feng, Y. Q. (2004). [Study on the risk factors and its interaction on Parkinson disease]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 25(6), 527-30.
Tan XH, et al. [Study On the Risk Factors and Its Interaction On Parkinson Disease]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25(6):527-30. PubMed PMID: 15231138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the risk factors and its interaction on Parkinson disease]. AU - Tan,Xian-Hua, AU - Wang,Shu-Mei, AU - Xue,Nan-Qing, AU - Teng,Wen-Tao, AU - Feng,Yue-Qiu, PY - 2004/7/3/pubmed PY - 2005/6/10/medline PY - 2004/7/3/entrez SP - 527 EP - 30 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 25 IS - 6 N2 - OBJECTIVE: To explore the risk factors of Parkinson disease (PD), interaction between family history of PD and other risk factors, as well as the relative strength of genetic factors over the vulnerability of PD. METHODS: One 1:1 matched case-control study including 157 pairs of cases and controls was conducted in Qilu Hospital of Shandong University. RESULTS: Conditional logistic regression analysis showed that family history of PD, mental labor, insecticide, alcohol drinking and history of depression all had positive relationship, while smoking had a negative relationship with PD. The AP (AB)s of family history of PD and insecticide, alcohol drinking, history of depression were 55.2%, 34.0%, 41.4% and the RERIs were 8.96, 3.31, 7.85 respectively. The heritability of PD patients' first degree relatives was 36.86% +/- 5.76%, and second degree relatives was 20.66% +/- 6.81%. CONCLUSION: Family history of PD had an additive model synergism on PD, coexisting with other risk factors. Genetic factors had a smaller action on PD than environmental factors. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/15231138/[Study_on_the_risk_factors_and_its_interaction_on_Parkinson_disease]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0254-6450&year=2004&vol=25&issue=6&fpage=527 DB - PRIME DP - Unbound Medicine ER -