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The iron-heart disease connection: is it dead or just hiding?
Ageing Res Rev. 2004 Jul; 3(3):355-67.AR

Abstract

More than 20 years ago it was proposed that differences in body iron stores may account for differential heart disease prevalence in men and women. In 1992 Finnish investigators presented intriguing supportive evidence for this proposal by showing that middle-aged men with normal but elevated serum ferritin, a biomarker of body iron stores, were at increased risk for acute myocardial infarction. During the past dozen years many studies have followed leading to intense debate on the role of iron in the development of heart disease. A meta-analysis of prospective studies found, however, no support for the iron-heart disease hypothesis. As new disease associations with iron status continue to be explored, consideration needs to be given to the lessons learned from these studies. Moreover, additional efforts need to be made to find a simple, high throughput and more satisfactory measure of the forms of iron in the body that are liable to do damage.

Authors+Show Affiliations

Mineral Bioavailability Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. richard.wood@tufts.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

15231242

Citation

Wood, Richard J.. "The Iron-heart Disease Connection: Is It Dead or Just Hiding?" Ageing Research Reviews, vol. 3, no. 3, 2004, pp. 355-67.
Wood RJ. The iron-heart disease connection: is it dead or just hiding? Ageing Res Rev. 2004;3(3):355-67.
Wood, R. J. (2004). The iron-heart disease connection: is it dead or just hiding? Ageing Research Reviews, 3(3), 355-67.
Wood RJ. The Iron-heart Disease Connection: Is It Dead or Just Hiding. Ageing Res Rev. 2004;3(3):355-67. PubMed PMID: 15231242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The iron-heart disease connection: is it dead or just hiding? A1 - Wood,Richard J, PY - 2004/04/01/received PY - 2004/04/02/accepted PY - 2004/7/3/pubmed PY - 2005/3/16/medline PY - 2004/7/3/entrez SP - 355 EP - 67 JF - Ageing research reviews JO - Ageing Res Rev VL - 3 IS - 3 N2 - More than 20 years ago it was proposed that differences in body iron stores may account for differential heart disease prevalence in men and women. In 1992 Finnish investigators presented intriguing supportive evidence for this proposal by showing that middle-aged men with normal but elevated serum ferritin, a biomarker of body iron stores, were at increased risk for acute myocardial infarction. During the past dozen years many studies have followed leading to intense debate on the role of iron in the development of heart disease. A meta-analysis of prospective studies found, however, no support for the iron-heart disease hypothesis. As new disease associations with iron status continue to be explored, consideration needs to be given to the lessons learned from these studies. Moreover, additional efforts need to be made to find a simple, high throughput and more satisfactory measure of the forms of iron in the body that are liable to do damage. SN - 1568-1637 UR - https://www.unboundmedicine.com/medline/citation/15231242/The_iron_heart_disease_connection:_is_it_dead_or_just_hiding L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568163704000169 DB - PRIME DP - Unbound Medicine ER -