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Voltammetric behaviour of rabeprazole at a glassy carbon electrode and its determination in tablet dosage form.
Farmaco. 2004 Jul; 59(7):515-8.F

Abstract

The oxidative behaviour of rabeprazole was studied at a glassy carbon electrode in Britton-Robinson (BR) buffer solutions using cyclic, linear sweep and differential-pulse voltammetry. The oxidation process was shown to be irreversible over the pH range (6.0-11.0) and was diffusion-adsorption controlled. An analytical method was developed for the determination of rabeprazole in BR buffer solution at pH 8.0 as supporting electrolyte. The anodic peak current varied linearly with rabeprazole concentration in the range 1.0 x 10(-6) to 2.0 x 10(-5) M of rabeprazole with a limit of detection of 4.0 x 10(-7) M. Validation parameters, such as sensitivity, accuracy, precision and recovery, were evaluated. The proposed method was applied to the determination of rabeprazole in the tablet dosage form. The results were compared with those obtained by a published high-performance liquid chromatographic method. No difference was found statistically.

Authors+Show Affiliations

Radi A
Department of Chemistry, Faculty of Science, Mansoura University, Dumyat 34517, Egypt. abdradi@yahoo.com
Abd El-Ghany N
No affiliation info available
Wahdan T
No affiliation info available

MeSH

2-PyridinylmethylsulfinylbenzimidazolesBenzimidazolesCarbonChromatography, High Pressure LiquidDosage FormsElectrodesHydrogen-Ion ConcentrationOmeprazoleOxidation-ReductionPotentiometryRabeprazoleReproducibility of ResultsSensitivity and SpecificityTablets

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15231426

Citation

Radi, A, et al. "Voltammetric Behaviour of Rabeprazole at a Glassy Carbon Electrode and Its Determination in Tablet Dosage Form." Farmaco (Societa Chimica Italiana : 1989), vol. 59, no. 7, 2004, pp. 515-8.
Radi A, Abd El-Ghany N, Wahdan T. Voltammetric behaviour of rabeprazole at a glassy carbon electrode and its determination in tablet dosage form. Farmaco. 2004;59(7):515-8.
Radi, A., Abd El-Ghany, N., & Wahdan, T. (2004). Voltammetric behaviour of rabeprazole at a glassy carbon electrode and its determination in tablet dosage form. Farmaco (Societa Chimica Italiana : 1989), 59(7), 515-8.
Radi A, Abd El-Ghany N, Wahdan T. Voltammetric Behaviour of Rabeprazole at a Glassy Carbon Electrode and Its Determination in Tablet Dosage Form. Farmaco. 2004;59(7):515-8. PubMed PMID: 15231426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Voltammetric behaviour of rabeprazole at a glassy carbon electrode and its determination in tablet dosage form. AU - Radi,A, AU - Abd El-Ghany,N, AU - Wahdan,T, PY - 2003/10/10/received PY - 2004/03/25/accepted PY - 2004/7/3/pubmed PY - 2005/2/16/medline PY - 2004/7/3/entrez SP - 515 EP - 8 JF - Farmaco (Societa chimica italiana : 1989) JO - Farmaco VL - 59 IS - 7 N2 - The oxidative behaviour of rabeprazole was studied at a glassy carbon electrode in Britton-Robinson (BR) buffer solutions using cyclic, linear sweep and differential-pulse voltammetry. The oxidation process was shown to be irreversible over the pH range (6.0-11.0) and was diffusion-adsorption controlled. An analytical method was developed for the determination of rabeprazole in BR buffer solution at pH 8.0 as supporting electrolyte. The anodic peak current varied linearly with rabeprazole concentration in the range 1.0 x 10(-6) to 2.0 x 10(-5) M of rabeprazole with a limit of detection of 4.0 x 10(-7) M. Validation parameters, such as sensitivity, accuracy, precision and recovery, were evaluated. The proposed method was applied to the determination of rabeprazole in the tablet dosage form. The results were compared with those obtained by a published high-performance liquid chromatographic method. No difference was found statistically. SN - 0014-827X UR - https://www.unboundmedicine.com/medline/citation/15231426/Voltammetric_behaviour_of_rabeprazole_at_a_glassy_carbon_electrode_and_its_determination_in_tablet_dosage_form_ DB - PRIME DP - Unbound Medicine ER -