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Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity.
Proc Natl Acad Sci U S A 2004; 101(28):10434-9PN

Abstract

Ghrelin plays a key role in the regulation of growth hormone secretion and energy homeostasis. Adiponectin is exclusively secreted by adipose tissue and is abundantly present in the circulation, with important effects on metabolism. We studied five lean and five obese young men [ages: 24.2 +/- 1.0 (lean) and 21.8 +/- 1.6 (obese) years (difference not significant); body mass indexes: 35.0 +/- 1.3 and 23.0 +/- 0.3 kg/m2 (P = 0.01)], sampled blood every 7 min over 24 h, and measured ghrelin, adiponectin, and leptin in 2,070 samples for a total of 6,210 data points. Circulating 24-h ghrelin showed significant ultradian fluctuations and an orderly pattern of release in lean and obese subjects with similar pulsatility characteristics. Plasma adiponectin concentrations were significantly lower in the obese group, with lower pulse height. In contrast to leptin, which is secreted in an orderly manner, the 24-h patterns of adiponectin were not significantly different from random in both the lean and obese groups. We show here that adipocytes can simultaneously secrete certain hormones, such as leptin, in patterns that are orderly, whereas other hormones, such as adiponectin, are secreted in patterns that appear to be random. The cross-approximate entropy statistic revealed pattern synchrony among ghrelin-leptin, ghrelin-adiponectin, and leptin-adiponectin hormone time series in the lean and obese subjects. Plasma ghrelin concentrations showed a nocturnal rise that exceeded the meal-associated increases in lean subjects, and this newly identified nocturnal rise was blunted in the obese. We suggest that the blunting of the nocturnal rise of ghrelin is a biological feature of human obesity.

Authors+Show Affiliations

Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1761, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15231997

Citation

Yildiz, Bulent O., et al. "Alterations in the Dynamics of Circulating Ghrelin, Adiponectin, and Leptin in Human Obesity." Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 28, 2004, pp. 10434-9.
Yildiz BO, Suchard MA, Wong ML, et al. Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci USA. 2004;101(28):10434-9.
Yildiz, B. O., Suchard, M. A., Wong, M. L., McCann, S. M., & Licinio, J. (2004). Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proceedings of the National Academy of Sciences of the United States of America, 101(28), pp. 10434-9.
Yildiz BO, et al. Alterations in the Dynamics of Circulating Ghrelin, Adiponectin, and Leptin in Human Obesity. Proc Natl Acad Sci USA. 2004 Jul 13;101(28):10434-9. PubMed PMID: 15231997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. AU - Yildiz,Bulent O, AU - Suchard,Marc A, AU - Wong,Ma-Li, AU - McCann,Samuel M, AU - Licinio,Julio, Y1 - 2004/07/01/ PY - 2004/7/3/pubmed PY - 2004/9/4/medline PY - 2004/7/3/entrez SP - 10434 EP - 9 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 101 IS - 28 N2 - Ghrelin plays a key role in the regulation of growth hormone secretion and energy homeostasis. Adiponectin is exclusively secreted by adipose tissue and is abundantly present in the circulation, with important effects on metabolism. We studied five lean and five obese young men [ages: 24.2 +/- 1.0 (lean) and 21.8 +/- 1.6 (obese) years (difference not significant); body mass indexes: 35.0 +/- 1.3 and 23.0 +/- 0.3 kg/m2 (P = 0.01)], sampled blood every 7 min over 24 h, and measured ghrelin, adiponectin, and leptin in 2,070 samples for a total of 6,210 data points. Circulating 24-h ghrelin showed significant ultradian fluctuations and an orderly pattern of release in lean and obese subjects with similar pulsatility characteristics. Plasma adiponectin concentrations were significantly lower in the obese group, with lower pulse height. In contrast to leptin, which is secreted in an orderly manner, the 24-h patterns of adiponectin were not significantly different from random in both the lean and obese groups. We show here that adipocytes can simultaneously secrete certain hormones, such as leptin, in patterns that are orderly, whereas other hormones, such as adiponectin, are secreted in patterns that appear to be random. The cross-approximate entropy statistic revealed pattern synchrony among ghrelin-leptin, ghrelin-adiponectin, and leptin-adiponectin hormone time series in the lean and obese subjects. Plasma ghrelin concentrations showed a nocturnal rise that exceeded the meal-associated increases in lean subjects, and this newly identified nocturnal rise was blunted in the obese. We suggest that the blunting of the nocturnal rise of ghrelin is a biological feature of human obesity. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/15231997/Alterations_in_the_dynamics_of_circulating_ghrelin_adiponectin_and_leptin_in_human_obesity_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=15231997 DB - PRIME DP - Unbound Medicine ER -