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Antibodies against human oxidized low-density lipoprotein (LDL) as markers for human plasma modified lipoproteins.
Med Sci Monit 2004; 10(7):BR207-14MS

Abstract

BACKGROUND

Recently there has been much interest in the significance and role of antibodies to oxidized LDL (oxLDL) in the plasma of humans and animals with evolving atherosclerosis. The focus in our study was directed on the significance of these antibodies for the pathogenesis and diagnosis of atherosclerosis.

MATERIAL/METHODS

Antibodies to human in vitro oxidized LDL were generated following the method of Kohler & Milstein and used to detect oxidized LDL in human plasma.

RESULTS

Several antibodies to oxLDL were selected for high reactivity against circulating modified LDL. The relationship between antibodies against oxLDL and circulating oxLDL level in human plasma was examined in normal and hyperlipidemic patients. The slight inverse relationship observed between anti-oxLDL antibodies and oxLDL levels in normal patients suggests that anti-oxLDL antibodies have a role in the clearance of oxLDL from circulation.

CONCLUSIONS

These antibodies can be considered as markers of the pathogenic determinants of atherosclerosis, such as enhanced lipid oxidation, pro-inflammatory stage, and impaired vasodilatation.

Authors+Show Affiliations

Institute of Cellular Biology and Pathology Nicolae Simionescu, Romanian Academy, Bucharest, Romania.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15232494

Citation

Radulescu, Luminita, et al. "Antibodies Against Human Oxidized Low-density Lipoprotein (LDL) as Markers for Human Plasma Modified Lipoproteins." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 10, no. 7, 2004, pp. BR207-14.
Radulescu L, Stancu C, Antohe F. Antibodies against human oxidized low-density lipoprotein (LDL) as markers for human plasma modified lipoproteins. Med Sci Monit. 2004;10(7):BR207-14.
Radulescu, L., Stancu, C., & Antohe, F. (2004). Antibodies against human oxidized low-density lipoprotein (LDL) as markers for human plasma modified lipoproteins. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 10(7), pp. BR207-14.
Radulescu L, Stancu C, Antohe F. Antibodies Against Human Oxidized Low-density Lipoprotein (LDL) as Markers for Human Plasma Modified Lipoproteins. Med Sci Monit. 2004;10(7):BR207-14. PubMed PMID: 15232494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies against human oxidized low-density lipoprotein (LDL) as markers for human plasma modified lipoproteins. AU - Radulescu,Luminita, AU - Stancu,Camelia, AU - Antohe,Felicia, Y1 - 2004/06/29/ PY - 2003/11/06/received PY - 2004/05/05/accepted PY - 2004/7/3/pubmed PY - 2004/9/15/medline PY - 2004/7/3/entrez SP - BR207 EP - 14 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 10 IS - 7 N2 - BACKGROUND: Recently there has been much interest in the significance and role of antibodies to oxidized LDL (oxLDL) in the plasma of humans and animals with evolving atherosclerosis. The focus in our study was directed on the significance of these antibodies for the pathogenesis and diagnosis of atherosclerosis. MATERIAL/METHODS: Antibodies to human in vitro oxidized LDL were generated following the method of Kohler & Milstein and used to detect oxidized LDL in human plasma. RESULTS: Several antibodies to oxLDL were selected for high reactivity against circulating modified LDL. The relationship between antibodies against oxLDL and circulating oxLDL level in human plasma was examined in normal and hyperlipidemic patients. The slight inverse relationship observed between anti-oxLDL antibodies and oxLDL levels in normal patients suggests that anti-oxLDL antibodies have a role in the clearance of oxLDL from circulation. CONCLUSIONS: These antibodies can be considered as markers of the pathogenic determinants of atherosclerosis, such as enhanced lipid oxidation, pro-inflammatory stage, and impaired vasodilatation. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/15232494/Antibodies_against_human_oxidized_low_density_lipoprotein__LDL__as_markers_for_human_plasma_modified_lipoproteins_ L2 - https://www.medscimonit.com/download/index/idArt/11707 DB - PRIME DP - Unbound Medicine ER -