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Celiac disease diagnosis in patients with giardiasis: high value of antitransglutaminase antibodies.
Am J Gastroenterol 2004; 99(7):1330-2AJ

Abstract

OBJECTIVES

The main objective of this study is to assess the presence of celiac disease (CD) in patients with giardiasis and to evaluate the tools for diagnosis of CD in these patients.

METHODS

A total of 40 patients with giardiasis were evaluated. Celiac disease was confirmed or discarded by intestinal biopsy and serological markers. Antigliadin antibodies were determined by ELISA and antitransglutaminase antibodies by one-step immunochromatographic assay and ELISA.

RESULTS

Out of the 40 patients with giardiasis 37 showed normal intestinal mucosa. In this group, IgA antibodies to gliadin were positive in 7 patients, yielding a specificity of 82%. All of them were negative for transglutaminase antibodies by the immunochromatographic assay and by ELISA (specificity of 100%). The remaining 3 patients showed a subtotal intestinal villous atrophy consistent with CD, however, only two presented IgA antibodies to transglutaminase and gliadin.

CONCLUSIONS

Due to its low specificity antigliadin antibodies are not useful for the screening of CD in patients with giardiasis. On the other hand, antitransglutaminase antibodies are highly specific and sensitive. One-step immunochromatographic assay is an easy and economic alternative. The findings of villous atrophy must be supported by other markers of CD to achieve the diagnosis of CD in these patients.

Authors+Show Affiliations

Department of Immunotechnology and Genomics, Center for Genetic Engineering and Biotechnology, Havana, Cuba.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15233673

Citation

Sorell, Luis, et al. "Celiac Disease Diagnosis in Patients With Giardiasis: High Value of Antitransglutaminase Antibodies." The American Journal of Gastroenterology, vol. 99, no. 7, 2004, pp. 1330-2.
Sorell L, Garrote JA, Galvan JA, et al. Celiac disease diagnosis in patients with giardiasis: high value of antitransglutaminase antibodies. Am J Gastroenterol. 2004;99(7):1330-2.
Sorell, L., Garrote, J. A., Galvan, J. A., Velazco, C., Edrosa, C. R., & Arranz, E. (2004). Celiac disease diagnosis in patients with giardiasis: high value of antitransglutaminase antibodies. The American Journal of Gastroenterology, 99(7), pp. 1330-2.
Sorell L, et al. Celiac Disease Diagnosis in Patients With Giardiasis: High Value of Antitransglutaminase Antibodies. Am J Gastroenterol. 2004;99(7):1330-2. PubMed PMID: 15233673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Celiac disease diagnosis in patients with giardiasis: high value of antitransglutaminase antibodies. AU - Sorell,Luis, AU - Garrote,Jose A, AU - Galvan,Jose A, AU - Velazco,Cira, AU - Edrosa,Carmen R, AU - Arranz,Eduardo, PY - 2004/7/6/pubmed PY - 2004/8/18/medline PY - 2004/7/6/entrez SP - 1330 EP - 2 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 99 IS - 7 N2 - OBJECTIVES: The main objective of this study is to assess the presence of celiac disease (CD) in patients with giardiasis and to evaluate the tools for diagnosis of CD in these patients. METHODS: A total of 40 patients with giardiasis were evaluated. Celiac disease was confirmed or discarded by intestinal biopsy and serological markers. Antigliadin antibodies were determined by ELISA and antitransglutaminase antibodies by one-step immunochromatographic assay and ELISA. RESULTS: Out of the 40 patients with giardiasis 37 showed normal intestinal mucosa. In this group, IgA antibodies to gliadin were positive in 7 patients, yielding a specificity of 82%. All of them were negative for transglutaminase antibodies by the immunochromatographic assay and by ELISA (specificity of 100%). The remaining 3 patients showed a subtotal intestinal villous atrophy consistent with CD, however, only two presented IgA antibodies to transglutaminase and gliadin. CONCLUSIONS: Due to its low specificity antigliadin antibodies are not useful for the screening of CD in patients with giardiasis. On the other hand, antitransglutaminase antibodies are highly specific and sensitive. One-step immunochromatographic assay is an easy and economic alternative. The findings of villous atrophy must be supported by other markers of CD to achieve the diagnosis of CD in these patients. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15233673/Celiac_disease_diagnosis_in_patients_with_giardiasis:_high_value_of_antitransglutaminase_antibodies_ L2 - http://Insights.ovid.com/pubmed?pmid=15233673 DB - PRIME DP - Unbound Medicine ER -