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[Low bone mineral density in children with Crohn's disease].
Arch Pediatr. 2004 Jul; 11(7):800-6.AP

Abstract

Recent studies have reported low bone mineral density in children with Crohn's disease. The aims of this retrospective study were to quantify its frequency and to search for risk factors.

POPULATION AND METHODS

Bone mineral density of 29 children with Crohn's disease was measured by dual-energy X-ray absorptiometry. All the children were taking calcium and vitamin D, during all the follow-up.

RESULTS

Osteoporosis (Z-score < or = -2.5 S.D.) was found in 38% of the children, and osteopenia in 38% (Z-score between -1 and -2.5 S.D.). Low bone mineral density was correlated with age, suggesting it begins with puberty. Daily corticosteroid exposure was significantly higher for patients with osteoporosis. Disease severity measured with Harvey-Bradshaw index and exposure to immunosuppressive drugs were almost statistically significant. Sex, height, duration and site of disease, nutritional assistance exposure were not associated with low bone mineral density.

CONCLUSION

This study confirms the high frequency of low bone mineral density in children with Crohn's disease, mainly during puberty. Corticosteroid exposure is a risk factor, and the disease severity, a probable one (non significant). New treatment strategy has to be defined to prevent and to treat this complication.

Authors+Show Affiliations

Service de gastroentérologie et de nutrition pédiatrique, hôpital Robert-Debré, AP-HP, 48, boulevard Serrurier, 75019 Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

15234375

Citation

Bourges, O, et al. "[Low Bone Mineral Density in Children With Crohn's Disease]." Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, vol. 11, no. 7, 2004, pp. 800-6.
Bourges O, Dorgeret S, Alberti C, et al. [Low bone mineral density in children with Crohn's disease]. Arch Pediatr. 2004;11(7):800-6.
Bourges, O., Dorgeret, S., Alberti, C., Hugot, J. P., Sebag, G., & Cézard, J. P. (2004). [Low bone mineral density in children with Crohn's disease]. Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie, 11(7), 800-6.
Bourges O, et al. [Low Bone Mineral Density in Children With Crohn's Disease]. Arch Pediatr. 2004;11(7):800-6. PubMed PMID: 15234375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Low bone mineral density in children with Crohn's disease]. AU - Bourges,O, AU - Dorgeret,S, AU - Alberti,C, AU - Hugot,J P, AU - Sebag,G, AU - Cézard,J P, PY - 2003/04/02/received PY - 2004/02/21/accepted PY - 2004/7/6/pubmed PY - 2004/9/24/medline PY - 2004/7/6/entrez SP - 800 EP - 6 JF - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JO - Arch Pediatr VL - 11 IS - 7 N2 - UNLABELLED: Recent studies have reported low bone mineral density in children with Crohn's disease. The aims of this retrospective study were to quantify its frequency and to search for risk factors. POPULATION AND METHODS: Bone mineral density of 29 children with Crohn's disease was measured by dual-energy X-ray absorptiometry. All the children were taking calcium and vitamin D, during all the follow-up. RESULTS: Osteoporosis (Z-score < or = -2.5 S.D.) was found in 38% of the children, and osteopenia in 38% (Z-score between -1 and -2.5 S.D.). Low bone mineral density was correlated with age, suggesting it begins with puberty. Daily corticosteroid exposure was significantly higher for patients with osteoporosis. Disease severity measured with Harvey-Bradshaw index and exposure to immunosuppressive drugs were almost statistically significant. Sex, height, duration and site of disease, nutritional assistance exposure were not associated with low bone mineral density. CONCLUSION: This study confirms the high frequency of low bone mineral density in children with Crohn's disease, mainly during puberty. Corticosteroid exposure is a risk factor, and the disease severity, a probable one (non significant). New treatment strategy has to be defined to prevent and to treat this complication. SN - 0929-693X UR - https://www.unboundmedicine.com/medline/citation/15234375/[Low_bone_mineral_density_in_children_with_Crohn's_disease]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929693X04002416 DB - PRIME DP - Unbound Medicine ER -