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Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa.
J Ethnopharmacol. 2004 Aug; 93(2-3):331-5.JE

Abstract

Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases. Three known bisbenzylisoquinoline alkaloids; cycleanine, cocsoline, and N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of Albertisia villosa root barks for the treatment of malaria and other infectious diseases in traditional Congolese medicine.

Authors+Show Affiliations

Lohombo-Ekomba ML
Institut Supérieur des Techniques Médicales, B.P. 774 Kinshasa XI, R.D. Congo.
Okusa PN
No affiliation info available
Penge O
No affiliation info available
Kabongo C
No affiliation info available
Choudhary MI
No affiliation info available
Kasende OE
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsAnti-Infective AgentsAntifungal AgentsAntimalarialsGram-Negative BacteriaGram-Positive BacteriaMalaria, FalciparumMenispermaceaeMicrobial Sensitivity TestsMitosporic FungiParasitic Sensitivity TestsPhytotherapyPlant ExtractsPlant RootsPlasmodium falciparum

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15234773

Citation

Lohombo-Ekomba, M-L, et al. "Antibacterial, Antifungal, Antiplasmodial, and Cytotoxic Activities of Albertisia Villosa." Journal of Ethnopharmacology, vol. 93, no. 2-3, 2004, pp. 331-5.
Lohombo-Ekomba ML, Okusa PN, Penge O, et al. Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa. J Ethnopharmacol. 2004;93(2-3):331-5.
Lohombo-Ekomba, M. L., Okusa, P. N., Penge, O., Kabongo, C., Choudhary, M. I., & Kasende, O. E. (2004). Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa. Journal of Ethnopharmacology, 93(2-3), 331-5.
Lohombo-Ekomba ML, et al. Antibacterial, Antifungal, Antiplasmodial, and Cytotoxic Activities of Albertisia Villosa. J Ethnopharmacol. 2004;93(2-3):331-5. PubMed PMID: 15234773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa. AU - Lohombo-Ekomba,M-L, AU - Okusa,P N, AU - Penge,O, AU - Kabongo,C, AU - Choudhary,M Iqbal, AU - Kasende,O E, PY - 2003/03/20/received PY - 2004/03/15/revised PY - 2004/04/01/accepted PY - 2004/7/6/pubmed PY - 2004/11/17/medline PY - 2004/7/6/entrez SP - 331 EP - 5 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 93 IS - 2-3 N2 - Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases. Three known bisbenzylisoquinoline alkaloids; cycleanine, cocsoline, and N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of Albertisia villosa root barks for the treatment of malaria and other infectious diseases in traditional Congolese medicine. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15234773/Antibacterial_antifungal_antiplasmodial_and_cytotoxic_activities_of_Albertisia_villosa_ DB - PRIME DP - Unbound Medicine ER -