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Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers.
J Ethnopharmacol. 2004 Aug; 93(2-3):391-5.JE

Abstract

Xanthine oxidase (XOD) is a key enzyme playing a role in hyperuricemia, catalyzing the oxidation of hypoxanthine to xanthine and then to uric acid. This study aimed to identify the XOD inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers. (Lythraceae), which was traditionally used as a folk medicine in the Philippines. Using a bioassay-guided fractionation technique, two active compounds were isolated from the aqueous extracts of the Lagerstroemia speciosa leaves, namely valoneic acid dilactone (VAD) and ellagic acid (EA). The result demonstrated that the XOD-inhibitory effect of VAD was a stronger than that of allopurinol, a clinical drug used for XOD inhibitor, with a non-competitive mode for the enzyme with respect to xanthine as the substrate. These results may explain and support the dietary use of the aqueous extracts from Lagerstroemia speciosa leaves for the prevention and treatment of hyperuricemia.

Authors+Show Affiliations

Central Research Institute, ITO EN Ltd. 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka 421-0516, Japan. t-unno@itoen.co.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15234783

Citation

Unno, Tomonori, et al. "Xanthine Oxidase Inhibitors From the Leaves of Lagerstroemia Speciosa (L.) Pers." Journal of Ethnopharmacology, vol. 93, no. 2-3, 2004, pp. 391-5.
Unno T, Sugimoto A, Kakuda T. Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers. J Ethnopharmacol. 2004;93(2-3):391-5.
Unno, T., Sugimoto, A., & Kakuda, T. (2004). Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers. Journal of Ethnopharmacology, 93(2-3), 391-5.
Unno T, Sugimoto A, Kakuda T. Xanthine Oxidase Inhibitors From the Leaves of Lagerstroemia Speciosa (L.) Pers. J Ethnopharmacol. 2004;93(2-3):391-5. PubMed PMID: 15234783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers. AU - Unno,Tomonori, AU - Sugimoto,Akio, AU - Kakuda,Takami, PY - 2003/08/18/received PY - 2004/03/05/revised PY - 2004/04/15/accepted PY - 2004/7/6/pubmed PY - 2004/11/17/medline PY - 2004/7/6/entrez SP - 391 EP - 5 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 93 IS - 2-3 N2 - Xanthine oxidase (XOD) is a key enzyme playing a role in hyperuricemia, catalyzing the oxidation of hypoxanthine to xanthine and then to uric acid. This study aimed to identify the XOD inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers. (Lythraceae), which was traditionally used as a folk medicine in the Philippines. Using a bioassay-guided fractionation technique, two active compounds were isolated from the aqueous extracts of the Lagerstroemia speciosa leaves, namely valoneic acid dilactone (VAD) and ellagic acid (EA). The result demonstrated that the XOD-inhibitory effect of VAD was a stronger than that of allopurinol, a clinical drug used for XOD inhibitor, with a non-competitive mode for the enzyme with respect to xanthine as the substrate. These results may explain and support the dietary use of the aqueous extracts from Lagerstroemia speciosa leaves for the prevention and treatment of hyperuricemia. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15234783/Xanthine_oxidase_inhibitors_from_the_leaves_of_Lagerstroemia_speciosa__L___Pers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S037887410400203X DB - PRIME DP - Unbound Medicine ER -