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A novel powder coating process for attaining taste masking and moisture protective films applied to tablets.
Int J Pharm. 2004 Jul 26; 279(1-2):127-39.IJ

Abstract

A novel powder coating process was developed for the application of taste masking and moisture protective films on tablets while avoiding the use of solvents or water. The coalescence of particles to form a polymeric film was investigated through studies of dry powder layering of micronized acrylic polymer (E PO) to produce free films. Theophylline containing tablets were coated with the same acrylic polymer in a laboratory scale spheronizer using a powder coating technique. The dry powder layer delayed the onset of drug release in pH 6.8 medium, depending on the coating level, while no delay was observed in pH 1.0 medium. The presence of hydrophilic polymers in the acrylic coating layer decreased the lag time for drug release in pH 6.8 medium, while only the presence of HPMC in the film slowed the drug release rate in acidic medium. The dry coating process was demonstrated to be a reliable alternative to solvent or aqueous film coating technologies for applying taste masking and moisture protective film coats onto compressed tablets. A controlled drug release profile was achieved in pH 6.8 media.

Authors+Show Affiliations

Cerea M
Drug Dynamics Institute, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA. matteo.cerea@unimi.it
Zheng W
No affiliation info available
Young CR
No affiliation info available
McGinity JW
No affiliation info available

MeSH

Delayed-Action PreparationsExcipientsMicroscopy, Electron, ScanningPolymethacrylic AcidsPowdersSolubilityTabletsTasteTechnology, PharmaceuticalTemperatureTheophyllineWater

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15234801

Citation

Cerea, Matteo, et al. "A Novel Powder Coating Process for Attaining Taste Masking and Moisture Protective Films Applied to Tablets." International Journal of Pharmaceutics, vol. 279, no. 1-2, 2004, pp. 127-39.
Cerea M, Zheng W, Young CR, et al. A novel powder coating process for attaining taste masking and moisture protective films applied to tablets. Int J Pharm. 2004;279(1-2):127-39.
Cerea, M., Zheng, W., Young, C. R., & McGinity, J. W. (2004). A novel powder coating process for attaining taste masking and moisture protective films applied to tablets. International Journal of Pharmaceutics, 279(1-2), 127-39.
Cerea M, et al. A Novel Powder Coating Process for Attaining Taste Masking and Moisture Protective Films Applied to Tablets. Int J Pharm. 2004 Jul 26;279(1-2):127-39. PubMed PMID: 15234801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel powder coating process for attaining taste masking and moisture protective films applied to tablets. AU - Cerea,Matteo, AU - Zheng,Weijia, AU - Young,Christopher R, AU - McGinity,James W, PY - 2004/03/02/received PY - 2004/04/16/revised PY - 2004/04/23/accepted PY - 2004/7/6/pubmed PY - 2004/11/13/medline PY - 2004/7/6/entrez SP - 127 EP - 39 JF - International journal of pharmaceutics JO - Int J Pharm VL - 279 IS - 1-2 N2 - A novel powder coating process was developed for the application of taste masking and moisture protective films on tablets while avoiding the use of solvents or water. The coalescence of particles to form a polymeric film was investigated through studies of dry powder layering of micronized acrylic polymer (E PO) to produce free films. Theophylline containing tablets were coated with the same acrylic polymer in a laboratory scale spheronizer using a powder coating technique. The dry powder layer delayed the onset of drug release in pH 6.8 medium, depending on the coating level, while no delay was observed in pH 1.0 medium. The presence of hydrophilic polymers in the acrylic coating layer decreased the lag time for drug release in pH 6.8 medium, while only the presence of HPMC in the film slowed the drug release rate in acidic medium. The dry coating process was demonstrated to be a reliable alternative to solvent or aqueous film coating technologies for applying taste masking and moisture protective film coats onto compressed tablets. A controlled drug release profile was achieved in pH 6.8 media. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/15234801/A_novel_powder_coating_process_for_attaining_taste_masking_and_moisture_protective_films_applied_to_tablets_ DB - PRIME DP - Unbound Medicine ER -