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The bioequivalence study of baclofen and lioresal tablets using capillary electrophoresis.
Biomed Chromatogr. 2004 Jun; 18(5):311-7.BC

Abstract

A simple and robust analytical method for rapid separation and sensitive quantification of baclofen in human plasma by capillary electrophoresis technique was developed. Electrophoretic separation was optimized and successfully performed using simple sodium tetraborate aqueous solution. Observed detection limit in biological material was 10 ng. Using UV detection at 200 nm excellent linearity (r = 0.999) was observed over the concentration range from 0.025 to 1.0 microg mL(-1). The described method has been validated and applied to the quantitative determination of baclofen in human plasma. The bioavailability of Baclofen (Polpharma) and Lioresal (Novartis) in 18 healthy volunteers was investigated. The results indicate bioequivalence of the reference and Baclofen preparations.

Authors+Show Affiliations

Kowalski P
Medical University of Gdańsk, Faculty of Pharmacy, Hallera 107, PL-80-416 Gdańsk, Poland.
Chmielewska A
No affiliation info available
Konieczna L
No affiliation info available
Oledzka I
No affiliation info available
Zarzycki PK
No affiliation info available
Lamparczyk H
No affiliation info available

MeSH

AdultBaclofenElectrophoresis, CapillaryFemaleHumansMaleReference ValuesSensitivity and SpecificityTabletsTherapeutic Equivalency

Pub Type(s)

Comparative Study
Journal Article
Validation Study

Language

eng

PubMed ID

15236439

Citation

Kowalski, Piotr, et al. "The Bioequivalence Study of Baclofen and Lioresal Tablets Using Capillary Electrophoresis." Biomedical Chromatography : BMC, vol. 18, no. 5, 2004, pp. 311-7.
Kowalski P, Chmielewska A, Konieczna L, et al. The bioequivalence study of baclofen and lioresal tablets using capillary electrophoresis. Biomed Chromatogr. 2004;18(5):311-7.
Kowalski, P., Chmielewska, A., Konieczna, L., Oledzka, I., Zarzycki, P. K., & Lamparczyk, H. (2004). The bioequivalence study of baclofen and lioresal tablets using capillary electrophoresis. Biomedical Chromatography : BMC, 18(5), 311-7.
Kowalski P, et al. The Bioequivalence Study of Baclofen and Lioresal Tablets Using Capillary Electrophoresis. Biomed Chromatogr. 2004;18(5):311-7. PubMed PMID: 15236439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The bioequivalence study of baclofen and lioresal tablets using capillary electrophoresis. AU - Kowalski,Piotr, AU - Chmielewska,Aleksandra, AU - Konieczna,Lucyna, AU - Oledzka,Ilona, AU - Zarzycki,Paweł K, AU - Lamparczyk,Henryk, PY - 2004/7/6/pubmed PY - 2005/2/19/medline PY - 2004/7/6/entrez SP - 311 EP - 7 JF - Biomedical chromatography : BMC JO - Biomed Chromatogr VL - 18 IS - 5 N2 - A simple and robust analytical method for rapid separation and sensitive quantification of baclofen in human plasma by capillary electrophoresis technique was developed. Electrophoretic separation was optimized and successfully performed using simple sodium tetraborate aqueous solution. Observed detection limit in biological material was 10 ng. Using UV detection at 200 nm excellent linearity (r = 0.999) was observed over the concentration range from 0.025 to 1.0 microg mL(-1). The described method has been validated and applied to the quantitative determination of baclofen in human plasma. The bioavailability of Baclofen (Polpharma) and Lioresal (Novartis) in 18 healthy volunteers was investigated. The results indicate bioequivalence of the reference and Baclofen preparations. SN - 0269-3879 UR - https://www.unboundmedicine.com/medline/citation/15236439/The_bioequivalence_study_of_baclofen_and_lioresal_tablets_using_capillary_electrophoresis_ DB - PRIME DP - Unbound Medicine ER -