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Impact of oxidative stress on neuronal survival.
Clin Exp Pharmacol Physiol. 2004 Jul; 31(7):397-406.CE

Abstract

1. Reactive oxygen species and oxidative state are slowly gaining acceptance in having a physiological relevance rather than just being the culprits in pathophysiological processes. The control of the redox environment of the cell provides for additional regulation in relation to signal transduction pathways. Conversely, aberrant regulation of oxidative state manifesting as oxidative stress can predispose a cell to adverse outcome. 2. The phosphatidylinositol 3-kinase/akt pathway is one such pathway that is partially regulated via oxidative state and, in an oxidative stress paradigm such as ischaemic-reperfusion injury, may be inactivated, which can lead to exacerbation of cell death. 3. Activation of nuclear factor (NF)-kappaB has been associated with oxidative stress. The role of NF-kappaB in neuronal cell death is widely debated, with major studies highlighting both a pro- and anti-apoptotic role for NF-kappaB, with the outcome being region, stimulus, dose and duration specific. 4. Oxidative state plays a key role in the regulation and control of numerous signal transduction pathways in the cell. Elucidating the mechanisms behind oxidative stress-mediated neuronal cell death is important in identifying potential putative targets for the treatment of diseases such as stroke.

Authors+Show Affiliations

Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15236624

Citation

Taylor, Juliet M., and Peter J. Crack. "Impact of Oxidative Stress On Neuronal Survival." Clinical and Experimental Pharmacology & Physiology, vol. 31, no. 7, 2004, pp. 397-406.
Taylor JM, Crack PJ. Impact of oxidative stress on neuronal survival. Clin Exp Pharmacol Physiol. 2004;31(7):397-406.
Taylor, J. M., & Crack, P. J. (2004). Impact of oxidative stress on neuronal survival. Clinical and Experimental Pharmacology & Physiology, 31(7), 397-406.
Taylor JM, Crack PJ. Impact of Oxidative Stress On Neuronal Survival. Clin Exp Pharmacol Physiol. 2004;31(7):397-406. PubMed PMID: 15236624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of oxidative stress on neuronal survival. AU - Taylor,Juliet M, AU - Crack,Peter J, PY - 2004/7/9/pubmed PY - 2005/1/26/medline PY - 2004/7/9/entrez SP - 397 EP - 406 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 31 IS - 7 N2 - 1. Reactive oxygen species and oxidative state are slowly gaining acceptance in having a physiological relevance rather than just being the culprits in pathophysiological processes. The control of the redox environment of the cell provides for additional regulation in relation to signal transduction pathways. Conversely, aberrant regulation of oxidative state manifesting as oxidative stress can predispose a cell to adverse outcome. 2. The phosphatidylinositol 3-kinase/akt pathway is one such pathway that is partially regulated via oxidative state and, in an oxidative stress paradigm such as ischaemic-reperfusion injury, may be inactivated, which can lead to exacerbation of cell death. 3. Activation of nuclear factor (NF)-kappaB has been associated with oxidative stress. The role of NF-kappaB in neuronal cell death is widely debated, with major studies highlighting both a pro- and anti-apoptotic role for NF-kappaB, with the outcome being region, stimulus, dose and duration specific. 4. Oxidative state plays a key role in the regulation and control of numerous signal transduction pathways in the cell. Elucidating the mechanisms behind oxidative stress-mediated neuronal cell death is important in identifying potential putative targets for the treatment of diseases such as stroke. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/15236624/Impact_of_oxidative_stress_on_neuronal_survival_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0305-1870&date=2004&volume=31&issue=7&spage=397 DB - PRIME DP - Unbound Medicine ER -